N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum.

Autor: Gabriella M A Forte, Martin R Pool, Colin J Stirling

Publikováno v: PLoS Biology, Vol 9, Iss 5, p e1001073 (2011)

Amino-terminal acetylation is probably the most common protein modification in eukaryotes with as many as 50%-80% of proteins reportedly altered in this way. Here we report a systematic analysis of the predicted N-terminal processing of cytosolic pro

Externí odkaz: https://doaj.org/article/60376e1c97c340798328344ab8afaec3

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

Autor: Catherine Vanhulle, Lynne A. Wolfe, Chumei Li, Eileen Baildam, Bertrand Isidor, John Tolmie, Yoandris del Toro Duany, Yanick J. Crow, Gabriella M A Forte, Gillian I. Rice, Simona Orcesi, Mondher Chouchane, Michael W. Beresford, Nuno Cordeiro, Beverley Anderson, Liesbeth De Waele, Pierre Lebon, Diana Rodriguez, James O'Sullivan, Marta Szybowska, Rolando Cimaz, Isabelle Desguerre, Giada Ariaudo, Manoj P. Menezes, Kate Webb, Robyn Whitney, Sun Hur, Simon G. Williams, Joyce Davidson, Russell C. Dale, Andrew Latchman, Laurence Faivre, Abigail Collins, Robert Robinson, Adeline Vanderver, Christiaan Scott, Iain B. McInnes, Enrica Riva, Cyril Mignot, Roberta Battini, José Pedro Vieira, Brigitte Bader-Meunier, Emma M. Jenkinson, Elisa Fazzi, Paolo Picco, Lieven Lagae, Elisabetta Salvatici, Manuela Casarano, Sameer M. Zuberi, Charles Marques Lourenço, Maria Margherita Mancardi, Alice Masurel-Paulet, John H. Livingston

Publikováno v: Nature Genetics; Vol 46
Nature Genetics
Nature genetics
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

The type I interferon system is integral to human antiviral immunity. However, inappropriate stimulation or defective negative regulation of this system can lead to inflammatory disease. We sought to determine the molecular basis of genetically uncha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0ab15ef0ea89e7de71b0fd808541bf
https://pubmed.ncbi.nlm.nih.gov/25080300

N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum.

Publikováno v: PLoS Biology. May2011, Vol. 9 Issue 5, p1-13. 13p. 1 Black and White Photograph, 1 Diagram, 4 Graphs.

Synonymous Mutations in RNASEH2A Create Cryptic Splice Sites Impairing RNase H2 Enzyme Function in Aicardi- Goutières Syndrome.

Autor: Rice, Gillian I., Reijns, Martin A.M., Coffin, Stephanie R., Forte, Gabriella M.A., Anderson, Beverley H., Szynkiewicz, Marcin, Gornall, Hannah, Gent, David, Leitch, Andrea, Botella, Maria P., Fazzi, Elisa, Gener, Blanca, Lagae, Lieven, Olivieri, Ivana, Orcesi, Simona, Swoboda, Kathryn J., Perrino, Fred W., Jackson, Andrew P., Crow, Yanick J.

Publikováno v: Human Mutation; Aug2013, Vol. 34 Issue 8, p1066-1070, 5p