Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gabriella Chan"'
Autor:
Yuanyuan Deng, Mian Bi, Fabien Delerue, Shelley L. Forrest, Gabriella Chan, Julia van der Hoven, Annika van Hummel, Astrid F. Feiten, Seojin Lee, Ivan Martinez-Valbuena, Tim Karl, Gabor G. Kovacs, Grant Morahan, Yazi D. Ke, Lars M. Ittner
Publikováno v:
Acta Neuropathologica. 144:637-650
In Alzheimer’s disease (AD), where amyloid-β (Aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause remains unclear. Here, we used the Collaborative Cross (CC) forward genetics m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::123224cd4ffed83438b98bbf4d468711
https://doi.org/10.1007/s00401-022-02457-w
https://doi.org/10.1007/s00401-022-02457-w
Autor:
Annika van Hummel, Miheer Sabale, Magdalena Przybyla, Julia van der Hoven, Gabriella Chan, Astrid F. Feiten, Roger S. Chung, Lars M. Ittner, Yazi D. Ke
Publikováno v:
Neuropathology and Applied Neurobiology. 49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9218ff0bcf0dbdb7cf32fcb37bbb2e
https://doi.org/10.1111/nan.12902
https://doi.org/10.1111/nan.12902
Publikováno v:
The American Journal of Pathology. 190:1713-1722
Amyotrophic lateral sclerosis is a rapidly progressing and fatal disease characterized by muscular atrophy due to loss of upper and lower motor neurons. Pathogenic mutations in the TARDBP gene encoding TAR DNA binding protein-43 (TDP-43) have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d4f2423e07ab81c1cd7b5c10ec2d62
https://doi.org/10.1016/j.ajpath.2020.04.009
https://doi.org/10.1016/j.ajpath.2020.04.009
Autor:
Arne Ittner, Glenda M. Halliday, Mian Bi, John R. Hodges, Matthew C. Kiernan, Astrid F. Feiten, Michael Kassiou, Jillian J. Kril, Yazi D. Ke, Gabriella Chan, Clement T. Loy, Julius Muller, Olivier Piguet, Lars M. Ittner, Greg T. Sutherland, Carol G. Au, John S. Mattick, Magdalena Przybyla, Kristie Stefanoska, Emmanuel Prikas
Publikováno v:
J Biol Chem
The microtubule-associated protein tau undergoes aberrant modification resulting in insoluble brain deposits in various neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal degeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084a6cab0026e66c87e67cc5c6dd9849
https://doi.org/10.1074/jbc.ra118.005263
https://doi.org/10.1074/jbc.ra118.005263
Autor:
Kong-Hung Sze, Thrimendra Kaushika Dissanayake, Cyril C. Y. Yip, Hanjun Zhao, Bingpeng Yan, Gabriella Chan, Kelvin K. W. To, Anthony Chin-Ki Ng
Publikováno v:
Journal of General Virology. 102
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aad828effbfe1fc61486ecfb4a4fe1
https://doi.org/10.1099/jgv.0.001593
https://doi.org/10.1099/jgv.0.001593
Autor:
Astrid F. Feiten, Nikolas K. Haass, Esmeralda Paric, Yazi D. Ke, Yuanyuan Deng, Annika van Hummel, Gabriella Chan, Sook Wern Chua, Lars M. Ittner, Celine Heu, Julia van der Hoven, Thomas Fath, Stefania Ippati
Publikováno v:
Proc Natl Acad Sci U S A
Neurons are postmitotic cells. Reactivation of the cell cycle by neurons has been reported in Alzheimer’s disease (AD) brains and models. This gave rise to the hypothesis that reentering the cell cycle renders neurons vulnerable and thus contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709079629f564f1af45d360c7a6b11aa
https://pubmed.ncbi.nlm.nih.gov/33737393
https://pubmed.ncbi.nlm.nih.gov/33737393
Autor:
Magdalena Przybyla, Gabriella Chan, Annika van Hummel, Mian Bi, Lisa S. Suh, Troy A. Butler, Olivier Piguet, Lars M. Ittner, Prita R. Asih, Yazi D. Ke, Julia van der Hoven, Stefania Ippati, Wei Siang Lee, Marco Morsch, Roger S. Chung, Glenda M. Halliday, Matthew C. Kiernan
Publikováno v:
The American Journal of Pathology. 188:1447-1456
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing and fatal disease characterized by muscular atrophy because of loss of upper and lower motor neurons. Histopathologically, most patients with ALS have abnormal cytoplasmic accumulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea768efc0bbc8f65baa7f9993bec097a
https://doi.org/10.1016/j.ajpath.2018.03.002
https://doi.org/10.1016/j.ajpath.2018.03.002
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7781, p 7781 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The abnormal mislocalisation and ubiquitinated protein aggregation of the TAR DNA binding protein 43 (TDP-43) within the cytoplasm of neurons and glia in the central nervous system (CNS) is a pathological hallmark of early-onset neurodegenerative dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce9f6bf29bba14f7bd1c73b0d106f9f
https://doi.org/10.3390/ijms22157781
https://doi.org/10.3390/ijms22157781
Autor:
Feifei Yin, Susanna K. P. Lau, Bingpeng Yan, Shuofeng Yuan, Pok Man Lai, Zijiao Zou, Jessica Oi-Ling Tsang, Gabriella Chan, Kwok-Yung Yuen, Hin Chu, Jasper Fuk-Woo Chan, Kong-Hung Sze, Cyril C. Y. Yip, Richard Y.T. Kao
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 23
Volume 20
Issue 23
Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the most common causes of hand, foot, and mouth disease. Severe EV-A71 and CV-A16 infections may be associated with life-threatening complications. However, the pathogenic mechanisms underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4c3330dae7f8a9e9274c9791e90499
http://europepmc.org/articles/PMC6928875
http://europepmc.org/articles/PMC6928875
Publikováno v:
Journal of Pure and Applied Chemistry Research, Vol 09, Iss 3, Pp 222-232 (2020)
Anti-inflammatory agents inhibit prostaglandin synthesis by blocking cyclooxygenases (COXs). The compounds extracted from ginger, 10-gingerol and 10-shogaol can inhibit inflammation but the mechanism of inhibition remains unclear. Here we used molecu
Externí odkaz:
https://doaj.org/article/9518f03effdd490fa8d145b2f14de864