Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gabriella, Miklossy"'
Autor:
Yinsong Zhu, Peibin Yue, Cody F. Dickinson, Justin K. Yang, Kyrstin Datanagan, Ning Zhai, Yi Zhang, Gabriella Miklossy, Francisco Lopez-Tapia, Marcus A. Tius, James Turkson
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-14 (2022)
Abstract Dysregulated gene expression programs and redox and metabolic adaptations allow cancer cells to survive under high oxidative burden. These mechanisms also represent therapeutic vulnerabilities. Using triple-negative breast cancer (TNBC) as a
Externí odkaz:
https://doaj.org/article/d34229ea9bfc4181a22308db8241c982
Autor:
Ram K. Modukuri, Diana Monsivais, Feng Li, Murugesan Palaniappan, Kurt M. Bohren, Zhi Tan, Angela F. Ku, Yong Wang, Chandrashekhar Madasu, Jian-Yuan Li, Suni Tang, Gabriella Miklossy, Stephen S. Palmer, Damian W. Young, Martin M. Matzuk
Publikováno v:
Journal of Medicinal Chemistry. 66:2143-2160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::899e0b4e19580a2aa29d02840b07db86
https://doi.org/10.1021/acs.jmedchem.2c01886
https://doi.org/10.1021/acs.jmedchem.2c01886
Autor:
James Turkson, Philip Williams, Peibin Yue, Christopher Chock, Gabriella Miklossy, Tyvette S. Hilliard
Supplementary text for publication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000ae642db6049f93def1f9bd892a3e6
https://doi.org/10.1158/1535-7163.22508353
https://doi.org/10.1158/1535-7163.22508353
Autor:
James Turkson, Philip Williams, Peibin Yue, Christopher Chock, Gabriella Miklossy, Tyvette S. Hilliard
Supplementary Figure S1. Phase-contrast microscopy imaging of cellular morphology of tumor cells after treatment with 15α-MP; Supplementary Figure S2. Global phospho-protein expression in U251MG cells and the changes induced in response to treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56703acef75999272f9bc52487acd404
https://doi.org/10.1158/1535-7163.22508347
https://doi.org/10.1158/1535-7163.22508347
Autor:
James Turkson, Philip Williams, Peibin Yue, Christopher Chock, Gabriella Miklossy, Tyvette S. Hilliard
Supplementary table of the statistical analysis of the TUNEL staining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546403fab7c49fa54983756c948da5fd
https://doi.org/10.1158/1535-7163.22508344
https://doi.org/10.1158/1535-7163.22508344
Autor:
Surendra Dawadi, Gabriella Miklossy, Nicholas Simmons, Martin M. Matzuk, Zhifeng Yu, Melek N. Ucisik, Pranavanand Nyshadham, Kurt M. Bohren, John C. Faver
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance To rapidly identify small-molecule lead compounds to target healthcare-associated proteases, we constructed a unique 9.8-million-membered protease-focused DNA-encoded chemical library. Affinity selection of this library with a healthcare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d02ebab15c77095173718e34457e534
https://doi.org/10.1073/pnas.2005447117
https://doi.org/10.1073/pnas.2005447117
Autor:
Taichi Noda, Masato Horie, Yoshitaka Fujihara, Takafumi Matsumura, Kurt M. Bohren, Takashi Kohda, Martin M. Matzuk, Masahito Ikawa, Zhifeng Yu, Manabu Ozawa, Masaru Okabe, Kentaro Shimada, Tomohiro Tobita, Mayo Kodani, Daiji Kiyozumi, Ryo Yamaguchi, Gabriella Miklossy
Publikováno v:
Science. 368:1132-1135
Local control of sperm maturation Newly produced spermatozoa within the testis do not have fertilizing ability but become fully functional when they mature in the epididymis. The development of the epididymis itself is dependent on testicular factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b948d244ce69cfc165ea6bd6fc4c27c
https://doi.org/10.1126/science.aay5134
https://doi.org/10.1126/science.aay5134
Autor:
Nicholas Simmons, Zhifeng Yu, Gabriella Miklossy, Ying-Chu Chen, Angela F. Ku, Melek N. Ucisik, Martin M. Matzuk, Kevin Riehle, Kurt M. Bohren, John C. Faver
Publikováno v:
Bioconjugate Chemistry
DNA-encoded chemical library (DECL) screens are a rapid and economical tool to identify chemical starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c70b496833044133d240147fabd09de
http://europepmc.org/articles/PMC7086399
http://europepmc.org/articles/PMC7086399
Autor:
Gabriella Miklossy, Aydan Kansu, Laszlo Szonyi, John R. Jimah, Craig C Grossman, Miguel Beckford, Ryan Kelly, Sanjay K. Banerjee, Zarife Kuloğlu, William E. Lee, Katalin Banki, Brian Niland, Zachary Oaks, Andras Perl
Publikováno v:
Journal of Inherited Metabolic Disease
Transaldolase (TAL) is an enzyme in the pentose phosphate pathway (PPP) that generates NADPH for protection against oxidative stress. While deficiency of other PPP enzymes, such as transketolase (TKT), are incompatible with mammalian cell survival, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d8010587e0d0d02fc4eae09dc13213
https://doi.org/10.1002/jimd.12197
https://doi.org/10.1002/jimd.12197
Autor:
J. Li, John C. Faver, Kurt M. Bohren, Nicholas Simmons, Ram K. Modukuri, Zhifeng Yu, Kevin Riehle, Murugesan Palaniappan, Gabriella Miklossy, Martin M. Matzuk
Publikováno v:
Bioconjugate Chemistry
A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chemical conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117b36702dc6c5da3707774558cf298d
http://europepmc.org/articles/PMC6706801
http://europepmc.org/articles/PMC6706801