Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Gabriella, Guerrini"'
Autor:
Letizia Crocetti, Andrei I. Khlebnikov, Gabriella Guerrini, Igor A. Schepetkin, Fabrizio Melani, Maria Paola Giovannoni, Mark T. Quinn
Publikováno v:
Molecules, Vol 29, Iss 11, p 2421 (2024)
Chronic inflammation contributes to a number of diseases. Therefore, control of the inflammatory response is an important therapeutic goal. To identify novel anti-inflammatory compounds, we synthesized and screened a library of 80 pyrazolo[1,5-a]quin
Externí odkaz:
https://doaj.org/article/007794058c7e431b94cac6664e57eecf
Autor:
Letizia Crocetti, Gabriella Guerrini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni
Publikováno v:
Molecules, Vol 28, Iss 7, p 3054 (2023)
The isosteric replacement of the benzene with thiophene ring is a chemical modification widely applied in medicinal chemistry. Several drugs containing the thiophene ring are marketed for treating various pathologies (osteoporosis, peripheral artery
Externí odkaz:
https://doaj.org/article/0e06483d87c64f6582d77899b45ca2dc
Autor:
Letizia Crocetti, Maria Paola Giovannoni, Niccolò Cantini, Gabriella Guerrini, Claudia Vergelli, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Human neutrophil elastase (HNE) is involved in a number of essential physiological processes and has been identified as a potential therapeutic target for treating acute and chronic lung injury. Nevertheless, only one drug, Sivelestat, has been appro
Externí odkaz:
https://doaj.org/article/1b275252690e4f0c89bfd76862ba0cff
Autor:
Maria Paola Giovannoni, Igor A. Schepetkin, Mark T. Quinn, Niccolò Cantini, Letizia Crocetti, Gabriella Guerrini, Antonella Iacovone, Paola Paoli, Patrizia Rossi, Gianluca Bartolucci, Marta Menicatti, Claudia Vergelli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1108-1124 (2018)
We report the synthesis and biological evaluation of a new series of 3- or 4-(substituted)phenylisoxazolones as HNE inhibitors. Due to tautomerism of the isoxazolone nucleus, two isomers were obtained as final compounds (2-NCO and 5-OCO) and the 2-NC
Externí odkaz:
https://doaj.org/article/94e1cfed692d40d3a460ad2d6d2ace76
Autor:
Letizia Crocetti, Gianluca Bartolucci, Agostino Cilibrizzi, Maria Paola Giovannoni, Gabriella Guerrini, Antonella Iacovone, Marta Menicatti, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn, Claudia Vergelli
Publikováno v:
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-15 (2017)
Abstract Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could rep
Externí odkaz:
https://doaj.org/article/3302c8916b934da28cb71e7bfeec8352
Autor:
Letizia Crocetti, Claudia Vergelli, Gabriella Guerrini, Maria Paola Giovannoni, Liliya N. Kirpotina, Andrei I. Khlebnikov, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Elena Lucarini, Igor A. Schepetkin, Mark T. Quinn
Publikováno v:
Molecules, Vol 26, Iss 21, p 6583 (2021)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation, cartilage damage and bone destruction. Although the pharmacological treatment of RA has evolved over the last few years, the new drugs have serious side
Externí odkaz:
https://doaj.org/article/794694ec985b41be98154621c4206a54
Autor:
Claudia Vergelli, Igor A. Schepetkin, Letizia Crocetti, Antonella Iacovone, Maria Paola Giovannoni, Gabriella Guerrini, Andrei I. Khlebnikov, Samuele Ciattini, Giovanna Ciciani, Mark T. Quinn
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 821-831 (2017)
Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, we report the synthesis, structure–activity relationship analysis,
Externí odkaz:
https://doaj.org/article/531fcc88b67644e79c69e45be171c5b9
Autor:
Letizia Crocetti, Maria Paola Giovannoni, Gabriella Guerrini, Silvia Lamanna, Fabrizio Melani, Gianluca Bartolucci, Marco Pallecchi, Paola Paoli, Martina Lippi, Junjie Wang, Gerhard Dahl
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2022
Volume 24
Issue 3
Pages: 2022
Pannexins are an interesting new target in medicinal chemistry, as they are involved in many pathologies such as epilepsy, ischemic stroke, cancer and Parkinson’s disease, as well as in neuropathic pain. They are a family of membrane channel protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ce9b38f42c40a7538145c056f1b684
Autor:
Letizia, Crocetti, Gabriella, Guerrini, Fabrizio, Melani, Claudia, Vergelli, Maria Paola, Mascia, Maria Paola, Giovannoni
Publikováno v:
International journal of molecular sciences. 23(21)
As a continuation of our study in the GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f21b5c453eba1e9df6ebfea3ad29dd30
https://pubmed.ncbi.nlm.nih.gov/36361842
https://pubmed.ncbi.nlm.nih.gov/36361842
Autor:
Agostino Cilibrizzi, Niccolò Cantini, Liliya N. Kirpotina, Andrei I. Khlebnikov, Mark T. Quinn, Letizia Crocetti, Gabriella Guerrini, Maria Paola Giovannoni, Claudia Vergelli, Paola Paoli, Igor A. Schepetkin, Patrizia Rossi
Publikováno v:
Chemical Biology & Drug Design
N‐formyl peptide receptors (FPR1, FPR2, and FPR3) play key roles in the regulation of inflammatory processes, and recently, it was demonstrated that FPR1 and FPR2 have a dual role in the progression/suppression of some cancers. Therefore, FPRs repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e07d602676f2ebba8e08fd734b7287
http://europepmc.org/articles/PMC8446315
http://europepmc.org/articles/PMC8446315