Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Gabriella, Forte"'
Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease
Autor:
Oriana Mandolfo, Helen Parker, Èlia Aguado, Yuko Ishikawa Learmonth, Ai Yin Liao, Claire O’Leary, Stuart Ellison, Gabriella Forte, Jessica Taylor, Shaun Wood, Rachel Searle, Rebecca J Holley, Hervé Boutin, Brian W Bigger
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1579-1602 (2024)
Abstract Mucopolysaccharidosis type IIIA (MPS IIIA) is a rare paediatric lysosomal storage disorder, caused by the progressive accumulation of heparan sulphate, resulting in neurocognitive decline and behavioural abnormalities. Anecdotal reports from
Externí odkaz:
https://doaj.org/article/6b33c2341e654421a1e1e4301ad75310
Autor:
Claire O’Leary, Gabriella Forte, Nadia L. Mitchell, Amir Saam Youshani, Adam Dyer, Martin P. Wellby, Katharina N. Russell, Samantha J. Murray, Nelly Jolinon, Simon A Jones, Kevin Stacey, Daniel M. Davis, Els Henckaerts, David N. Palmer, Ian Kamaly-Asl, Brian W. Bigger
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Mucopolysaccharidosis IIIC (MPSIIIC) is one of four Sanfilippo diseases sharing clinical symptoms of severe cognitive decline and shortened lifespan. The missing enzyme, heparan sulfate acetyl-CoA: α-glucosaminide-N-acetyltransfe
Externí odkaz:
https://doaj.org/article/193bffc76643439f9aca34c4f8d77145
Autor:
Mueez Waqar, Federico Roncaroli, Ibrahim Djoukhadar, Leila Akkari, Claire O'Leary, Lauren Hewitt, Gabriella Forte, Richard Jackson, Eline Hessen, Lisa Withington, William Beasley, Jenny Richardson, Christopher Golby, Philip Whitehurst, Rovel Colaco, Matthew Bailey, Konstantina Karabatsou, Pietro I. D'Urso, Catherine McBain, David J. Coope, Gerben R. Borst
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 39, Iss , Pp 100585- (2023)
Background: Glioblastoma is a high-grade aggressive neoplasm whose outcomes have not changed in decades. In the current treatment pathway, tumour growth continues and remains untreated for several weeks post-diagnosis. Intensified upfront therapy cou
Externí odkaz:
https://doaj.org/article/a0c1d9a40fee4794b2b2595cd357ed30
Autor:
A. Saam Youshani, Samuel Rowlston, Claire O’Leary, Gabriella Forte, Helen Parker, Aiyin Liao, Brian Telfer, Kaye Williams, Ian D. Kamaly-Asl, Brian W. Bigger
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Chimeric mouse models generated via adoptive bone marrow transfer are the foundation for immune cell tracking in neuroinflammation. Chimeras that exhibit low chimerism levels, blood-brain barrier disruption and pro-inflammatory ef
Externí odkaz:
https://doaj.org/article/24b3db9776604feebdfec27f8592cf84
Autor:
Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bra
Externí odkaz:
https://doaj.org/article/2cc2c4e30f3345eab7d6fbf48727ec24
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
Although, for many decades, the day–night rhythm in resting heart rate has been attributed to the parasympathetic branch of the autonomic nervous system (high vagal tone during sleep), recently we have shown that there is a circadian clock in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c383ea05e1f88e65ef8b2e86f188d5
https://doi.org/10.1098/rstb.2022.0179
https://doi.org/10.1098/rstb.2022.0179
Autor:
Shaun Roger Wood, Ahsan Chaudrhy, Stuart Ellison, Rachel Searle, Constance Burgod, Ghazala Tehseen, Gabriella Forte, Claire O'Leary, Helene F Gleitz, Aiyin Liao, James Cook, Rebecca Jane Holley, Brian Bigger
Mucopolysaccharidosis type II (MPSII) is a lysosomal storage disease caused by a mutation in the IDS gene, resulting in deficiency of the enzyme iduronate-2-sulfatase (IDS) causing heparan sulfate (HS) and dermatan sulfate (DS) accumulation in all ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde2ec6ef8b048fb8cd4a96350c9ba4e
http://hdl.handle.net/10044/1/104683
http://hdl.handle.net/10044/1/104683
Autor:
Luca Soattin, Daniele Lagomarsino-Oneto, Gabriella Forte, NIcholas Black, Megan K. McKie, Matthew Smith, Mark R. Boyett, Alicia D'Souza, Gwilym M. Morris
Publikováno v:
Heart Rhythm. 20:S143-S144
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aed9b0284dd8dcae6800225a2045a18d
https://doi.org/10.1016/j.hrthm.2023.03.494
https://doi.org/10.1016/j.hrthm.2023.03.494
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:133-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6ac6383fa9e7fd19a7a7f8b56c225d1
https://doi.org/10.1016/j.yjmcc.2022.08.261
https://doi.org/10.1016/j.yjmcc.2022.08.261
Autor:
Helen Parker, Alina Pandele, Gabriella Forte, Alan J. Dickson, Jessica T. Taylor, Kaye J. Williams, Shaun Wood, Catherine McBain, Martin G. McCabe, Erica Nathan, Stuart M. Ellison, Egor Zindy, Konstantina Karabatsou, Brian W. Bigger, Mark Elvin
Publikováno v:
Neuro-Oncology
Taylor, J T, Ellison, S, Pandele, A, Wood, S, Nathan, E, Forte, G, Parker, H, Zindy, E, Elvin, M, Dickson, A, Williams, K J, Karabatsou, K, McCabe, M, McBain, C & Bigger, B W 2020, ' Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma ', Neuro-Oncology, vol. 22, no. 9, pp. 1289-1301 . https://doi.org/10.1093/neuonc/noaa051
Neuro-oncology, 22 (9
Taylor, J T, Ellison, S, Pandele, A, Wood, S, Nathan, E, Forte, G, Parker, H, Zindy, E, Elvin, M, Dickson, A, Williams, K J, Karabatsou, K, McCabe, M, McBain, C & Bigger, B W 2020, ' Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma ', Neuro-Oncology, vol. 22, no. 9, pp. 1289-1301 . https://doi.org/10.1093/neuonc/noaa051
Neuro-oncology, 22 (9
Background Glioblastoma (GBM) has been extensively researched over the last few decades, yet despite aggressive multimodal treatment, recurrence is inevitable and second-line treatment options are limited. Here, we demonstrate how high-throughput scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be5be98903ad70a82e189cf06eaacba
http://europepmc.org/articles/PMC7523458
http://europepmc.org/articles/PMC7523458