Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gabriella, Cseke"'
Autor:
Stacey M. Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D. Cansfield, Julie E. Cansfield, Miles S. Congreve, Gabriella Cseke, Francesca Deflorian, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Renata Rupcic, Gordon Saxty, Stephen P. Watson
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1776-1782
The diastereomeric macrocyclic calcitonin generelated peptide (CGRP) antagonists HTL0029881 (3) and HTL0029882 (4), in which the stereochemistry of a spiro center is reversed, surprisingly demonstrate comparable potency. X-ray crystallographic charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6056f84865bf327ec61e26bf41ed7b3
https://doi.org/10.1021/acsmedchemlett.2c00400
https://doi.org/10.1021/acsmedchemlett.2c00400
Autor:
Andrew D. Cansfield, Mark A. Ator, Joydeep Banerjee, Michael Bestwick, Andrea Bortolato, Giles A. Brown, Jason Brown, Kristina Butkovic, Julie E. Cansfield, John A. Christopher, Miles Congreve, Gabriella Cseke, Francesca Deflorian, Benjamin Dugan, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Goran Landek, Jonathan Mason, Alistair O’Brien, Gregory R. Ott, Renata Rupcic, Gordon Saxty, Stacey M. Southall, Rahela Zadravec, Stephen P. Watson
Publikováno v:
ACS Chemical Neuroscience. 13:751-765
A series of macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonists identified using structure-based design principles, exemplified by HTL0028016 (1) and HTL0028125 (2), is described. Structural characterization by X-ray crystallograp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c446db762c3a729f140cd365a9977f1b
https://doi.org/10.1021/acschemneuro.1c00696
https://doi.org/10.1021/acschemneuro.1c00696
Autor:
Sarah J, Bucknell, Mark A, Ator, Alastair J H, Brown, Jason, Brown, Andrew D, Cansfield, Julie E, Cansfield, John A, Christopher, Miles, Congreve, Gabriella, Cseke, Francesca, Deflorian, Christopher R, Jones, Jonathan S, Mason, M Alistair, O'Brien, Gregory R, Ott, Mark, Pickworth, Stacey M, Southall
Publikováno v:
Journal of medicinal chemistry. 63(14)
Structure-based drug design enabled the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fe466b9ae04aa713be834ac63134aab
https://pubmed.ncbi.nlm.nih.gov/32558564
https://pubmed.ncbi.nlm.nih.gov/32558564
Autor:
Mathieu Rappas, Ammar A. E. Ali, Kirstie A. Bennett, Jason D. Brown, Sarah J. Bucknell, Miles Congreve, Robert M. Cooke, Gabriella Cseke, Chris de Graaf, Andrew S. Doré, James C. Errey, Ali Jazayeri, Fiona H. Marshall, Jonathan S. Mason, Richard Mould, Jayesh C. Patel, Benjamin G. Tehan, Malcolm Weir, John A. Christopher
[Image: see text] The orexin system, which consists of the two G protein-coupled receptors OX(1) and OX(2), activated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioral arousal, sleep, and wakefulness and has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0d1e9cf558d3f2bc1e5e706f4b6a9b
https://europepmc.org/articles/PMC7050010/
https://europepmc.org/articles/PMC7050010/
Autor:
Mark, Soave, Gabriella, Cseke, Catherine J, Hutchings, Alastair J H, Brown, Jeanette, Woolard, Stephen J, Hill
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turke
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63b12cac034dba90fb7f5e28b08c1ed2
https://pubmed.ncbi.nlm.nih.gov/29102678
https://pubmed.ncbi.nlm.nih.gov/29102678
Autor:
John V. Williams, Gabriella Cseke, David W. Wright, Sharon J. Tollefson, Melissa S. Maginnis, Amy B. Podsiad, Reagan G. Cox, Terence S. Dermody
Publikováno v:
Proceedings of the National Academy of Sciences. 106:1566-1571
Human metapneumovirus (hMPV) is a recently described paramyxovirus that causes lower respiratory infections in children and adults worldwide. The hMPV fusion (F) protein is a membrane-anchored glycoprotein and major protective antigen. All hMPV F pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f65a82e23cbbf930dc0f4caf1f0a26e2
https://doi.org/10.1073/pnas.0801433106
https://doi.org/10.1073/pnas.0801433106
Autor:
Bryan E. Shepherd, Pietro Paolo Sanna, Christopher J. Keefer, Amy B. Podsiad, Dennis R. Burton, James E. Crowe, R. Anthony Williamson, John V. Williams, Gabriella Cseke, David W. Wright, Sharon J. Tollefson, Ann J. Hessell, Zhifeng Chen
Publikováno v:
Journal of Virology. 81:8315-8324
Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that is a major cause of lower-respiratory-tract disease. hMPV is associated with more severe disease in infants and persons with underlying medical conditions. Animal studies have s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a324200d284fee79f0ddbd0fd2239e9a
https://doi.org/10.1128/jvi.00106-07
https://doi.org/10.1128/jvi.00106-07
Autor:
Joyce E. Johnson, Sharon J. Tollefson, Gabriella Cseke, David W. Wright, James E. Crowe, John V. Williams
Publikováno v:
Journal of Virology. 81:698-707
Human metapneumovirus (hMPV) is a recently described paramyxovirus that is a major cause of upper and lower respiratory infection in children and adults worldwide. A safe and effective vaccine could decrease the burden of disease associated with this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43836182f881cd3032f67f742b706c9
https://doi.org/10.1128/jvi.00844-06
https://doi.org/10.1128/jvi.00844-06
Autor:
Gabriella, Cseke, Melissa S, Maginnis, Reagan G, Cox, Sharon J, Tollefson, Amy B, Podsiad, David W, Wright, Terence S, Dermody, John V, Williams
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(5)
Human metapneumovirus (hMPV) is a recently described paramyxovirus that causes lower respiratory infections in children and adults worldwide. The hMPV fusion (F) protein is a membrane-anchored glycoprotein and major protective antigen. All hMPV F pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b37c2abc289b4e3687de787799d415a3
https://pubmed.ncbi.nlm.nih.gov/19164533
https://pubmed.ncbi.nlm.nih.gov/19164533