Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gabriele Siegel"'
The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides
Autor:
Gabriele Siegel, Hermeto Gerber, Philipp Koch, Oliver Bruestle, Patrick C. Fraering, Lawrence Rajendran
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 1967-1976 (2017)
Alzheimer’s disease is characterized by intracerebral deposition of β-amyloid (Aβ). While Aβ40 is the most abundant form, neurotoxicity is mainly mediated by Aβ42. Sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretases
Externí odkaz:
https://doaj.org/article/d74681e3488f4907a3332cd53286c052
Autor:
Vinod Udayar, Virginie Buggia-Prévot, Rita L. Guerreiro, Gabriele Siegel, Naresh Rambabu, Amanda L. Soohoo, Moorthi Ponnusamy, Barbara Siegenthaler, Jitin Bali, AESG, Mikael Simons, Jonas Ries, Manojkumar A. Puthenveedu, John Hardy, Gopal Thinakaran, Lawrence Rajendran
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1536-1551 (2013)
Alzheimer’s disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides, which are generated from amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are membrane associated, but whether membrane t
Externí odkaz:
https://doaj.org/article/efa3cad5b6934baaafd00b6e63a8d624
Autor:
Lawrence Rajendran, Gabriele Siegel
Publikováno v:
Matters.
The Alzheimer’s disease γ-secretase generates higher 42:40 ratios for β-amyloid than for p3 peptides
Autor:
Philipp Koch, Lawrence Rajendran, Oliver Bruestle, Hermeto Gerber, Gabriele Siegel, Patrick C. Fraering
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 1967-1976 (2017)
Summary Alzheimer's disease is characterized by intracerebral deposition of β-amyloid (Aβ). While Aβ 40 is the most abundant form, neurotoxicity is mainly mediated by Aβ 42 . Sequential cleavage of amyloid precursor protein (APP) by β- and γ-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a7d97a8155da825dffddad758787d3
http://doc.rero.ch/record/305032/files/ger_adg_sm.pdf
http://doc.rero.ch/record/305032/files/ger_adg_sm.pdf
Publikováno v:
Current Opinion in Genetics & Development. 21:491-497
The regulation of synapse formation and plasticity in the developing and adult brain underlies a complex interplay of intrinsic genetic programs and extrinsic factors. Recent research identified microRNAs (miRNAs), a class of small non-coding RNAs, a
Autor:
Peter H. Störchel, Simon Sumer, Gabriele Siegel, Juliane Thümmler, Ayla Aksoy-Aksel, Federico Zampa, Gerhard Schratt
Publikováno v:
The EMBO journal. 34(17)
MicroRNAs (miRNAs) are important regulators of neuronal development, network connectivity, and synaptic plasticity. While many neuronal miRNAs were previously shown to modulate neuronal morphogenesis, little is known regarding the regulation of miRNA
Autor:
Sakari Kauppinen, Clara J L Busch, Andreas Draguhn, Katja Hübel, Frank J. Dekker, Christian Hedberg, Herbert Waldmann, Marc Rehmsmeier, Gerhard Schratt, Balamurugan Rengarajan, Javier Martinez, Gregor Obernosterer, Silvia Bicker, Gabriele Siegel, Philipp F Leuschner, Christina G. Kane, Sharof Khudayberdiev, Carsten Drepper, Martin Oehmen, Michael E. Greenberg, Mette Christensen, Roberto Fiore
The microRNA pathway has been implicated in the regulation of synaptic protein synthesis and ultimately in dendritic spine morphogenesis, a phenomenon associated with long-lasting forms of memory. However, the particular microRNAs (miRNAs) involved a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999fc8682474a0a0d7f79c99b6f6bbd0
https://europepmc.org/articles/PMC3595613/
https://europepmc.org/articles/PMC3595613/
Autor:
Herbert Waldmann, Sakari Kauppinen, Gregor Obernosterer, Roberto Fiore, Gabriele Siegel, Michael E. Greenberg, Javier Martinez, Sharof Khudayberdiev, Marc Rehmsmeier, Gerhard Schratt
Publikováno v:
GBM Annual Spring meeting Mosbach 2009. 2009
Autor:
Gabriele Siegel, Sharof Khudayberdiev, Steven W. Flavell, Mette Christensen, Roberto Fiore, Tae Kyung Kim, Michael E. Greenberg, Gerhard Schratt
Publikováno v:
The EMBO Journal
Neuronal activity orchestrates the proper development of the neuronal circuitry by regulating both transcriptional and post-transcriptional gene expression programmes. How these programmes are coordinated, however, is largely unknown. We found that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609812538fcdff3a1469c5db739516f3
https://doi.org/10.5167/uzh-50164
https://doi.org/10.5167/uzh-50164
The development and function of the nervous system is orchestrated by a plethora of gene regulatory mechanisms. MicroRNAs (miRNAs), an abundant class of small non-coding RNAs, are emerging as important post-transcriptional regulators of gene expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378e710152b60246a14f87e88ec60906
https://doi.org/10.5167/uzh-50163
https://doi.org/10.5167/uzh-50163