Výsledky vyhledávání - "Gabriele Noffz"

Autoimmunity and tumor immunity induced by immune responses to mutations in self

Autor: Olivia Lou, Alan N. Houghton, José A. Guevara-Patiño, Barry J. Kappel, Manuel E. Engelhorn, Jason S. Gold, Andrea T. Hooper, Gabriele Noffz

Publikováno v: Nature Medicine. 12:198-206

Little is known about the consequences of immune recognition of mutated gene products, despite their potential relevance to autoimmunity and tumor immunity. To identify mutations that induce immunity, here we have developed a systematic approach in w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468ef7d618a49f1fac3a8d175917d7f6
https://doi.org/10.1038/nm1363

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Nonviral and Viral Gene Transfer Into Different Subsets of Human Dendritic Cells Yield Comparable Efficiency of Transfection

Autor: Andreas Lundqvist, Gabriele Noffz, Maxim Pavlenko, Pavel Pisa, Norman J. Maitland, Stein Saebøe-Larssen, Timothy Fong

Publikováno v: Karolinska Institutet

Among the many promising cancer immunotherapeutic strategies, dendritic cells (DC) have become of particular interest. This study aims to optimize a clinical grade protocol for culture and transfection of human DC. Monocytes and CD34(+) hematopoietic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16eeb63833c4692e63cce8e28864216
https://doi.org/10.1097/00002371-200211000-00001

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Strategies to overcome immune ignorance and tolerance

Autor: Jason S. Gold, Nathalie E. Blachere, Polly D. Gregor, Miguel-Angel Perales, Manuel E. Engelhorn, Alan N. Houghton, Cristina R. Ferrone, Jedd D. Wolchok, Gabriele Noffz

Publikováno v: Seminars in Cancer Biology. 12:63-71

Cancer poses a difficult problem for immunotherapy because it arises from the host's own tissues. Many of the target antigens are tissue-specific molecules shared by cancer cells and normal cells. Thus, these are weak antigens that do not typically e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb6e2c2d542b6aa9e68c0667e07a8d6
https://doi.org/10.1006/scbi.2001.0397

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Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1

Autor: Max Petersson, Jehad Charo, Flavio Salazar-Onfray, Gabriele Noffz, Mariette Mohaupt, Zhihai Qin, George Klein, Thomas Blankenstein, Rolf Kiessling

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(5)

Tumor cells that are treated with rIL-10 or transfected with the IL-10 gene show phenotypic changes. These include low but peptide-inducible expression of MHC class I, low sensitivity to specific CTL-mediated lysis, and increased NK sensitivity. In v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b6358262f95a323d0ba093a51e2d5c
https://pubmed.ncbi.nlm.nih.gov/9725200

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