Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gabriele Manhart"'
Autor:
Elizabeth Heyes, Anna S. Wilhelmson, Anne Wenzel, Gabriele Manhart, Thomas Eder, Mikkel B. Schuster, Edwin Rzepa, Sachin Pundhir, Teresa D’Altri, Anne-Katrine Frank, Coline Gentil, Jakob Woessmann, Erwin M. Schoof, Manja Meggendorfer, Jürg Schwaller, Torsten Haferlach, Florian Grebien, Bo T. Porse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPA NT), promoting expression of the leuk
Externí odkaz:
https://doaj.org/article/015f842398434c8ab9d3b64437bd9772
Autor:
Jessica Ebner, Johannes Schmoellerl, Martin Piontek, Gabriele Manhart, Selina Troester, Bing Z. Carter, Heidi Neubauer, Richard Moriggl, Gergely Szakács, Johannes Zuber, Thomas Köcher, Michael Andreeff, Wolfgang R. Sperr, Peter Valent, Florian Grebien
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The BCL-2 inhibitor Venetoclax is a promising agent for the treatment of acute myeloid leukemia (AML). However, many patients are refractory to Venetoclax, and resistance develops quickly. ATP-binding cassette (ABC) transporters mediate chem
Externí odkaz:
https://doaj.org/article/c9c4a1f7bca449409f4ee0bf6e5c440b
Autor:
Ludovica Proietti, Srikanth Kodali, Gemma Valcarcel, Anna Vanessa Lopez-Rubio, Patrizia Pessina, Thomas Eder, Yingzhi Cui, Florencia Levin, Bernhard Alber, Gabriele Manhart, Alessandro Fatica, Jose Louis Sardina, Bruno DI Stefano, Florian Grebien
Publikováno v:
HemaSphere, Vol 7, p e8249393 (2023)
Externí odkaz:
https://doaj.org/article/9d84021610664209a77b5009bd067c54
Publikováno v:
Bio-Protocol, Vol 12, Iss 24 (2022)
CRISPR/Cas9 screening has revolutionized functional genomics in biomedical research and is a widely used approach for the identification of genetic dependencies in cancer cells. Here, we present an efficient and versatile protocol for the cloning of
Externí odkaz:
https://doaj.org/article/2269de02e82740658f12b6a8cb7a3b76
Autor:
Jennifer Schwestka, Julia König-Beihammer, Yun-Ji Shin, Ulrike Vavra, Nikolaus F. Kienzl, Clemens Grünwald-Gruber, Daniel Maresch, Miriam Klausberger, Elisabeth Laurent, Maria Stadler, Gabriele Manhart, Jasmin Huber, Manuela Hofner, Klemens Vierlinger, Andreas Weinhäusel, Ines Swoboda, Christoph J. Binder, Wilhelm Gerner, Florian Grebien, Friedrich Altmann, Lukas Mach, Eva Stöger, Richard Strasser
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
The receptor binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in the virus-host cell interaction, and viral infection. The RBD is a major target for neutralizing antibodies, whilst recombinant RBD is commonly used as an antigen i
Externí odkaz:
https://doaj.org/article/df218680a37f4783b7a28aaab0e9205d
Autor:
Miriam Klausberger, Mark Duerkop, Helmuth Haslacher, Gordana Wozniak-Knopp, Monika Cserjan-Puschmann, Thomas Perkmann, Nico Lingg, Patricia Pereira Aguilar, Elisabeth Laurent, Jelle De Vos, Manuela Hofner, Barbara Holzer, Maria Stadler, Gabriele Manhart, Klemens Vierlinger, Margot Egger, Lisa Milchram, Elisabeth Gludovacz, Nicolas Marx, Christoph Köppl, Christopher Tauer, Jürgen Beck, Daniel Maresch, Clemens Grünwald-Gruber, Florian Strobl, Peter Satzer, Gerhard Stadlmayr, Ulrike Vavra, Jasmin Huber, Markus Wahrmann, Farsad Eskandary, Marie-Kathrin Breyer, Daniela Sieghart, Peter Quehenberger, Gerda Leitner, Robert Strassl, Alexander E. Egger, Christian Irsara, Andrea Griesmacher, Gregor Hoermann, Günter Weiss, Rosa Bellmann-Weiler, Judith Loeffler-Ragg, Nicole Borth, Richard Strasser, Alois Jungbauer, Rainer Hahn, Jürgen Mairhofer, Boris Hartmann, Nikolaus B. Binder, Gerald Striedner, Lukas Mach, Andreas Weinhäusel, Benjamin Dieplinger, Florian Grebien, Wilhelm Gerner, Christoph J. Binder, Reingard Grabherr
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103348- (2021)
Background: Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection or vaccination. While first-generation antibody tests have primarily provided qualitative results, accurate seroprevalence studies and track
Externí odkaz:
https://doaj.org/article/ba1f6bc358354ac0a5baccc4ebc09bec
Autor:
Elizabeth Heyes, Anna S. Wilhelmson, Anne Wenzel, Gabriele Manhart, Thomas Eder, Mikkel B. Schuster, Edwin Rzepa, Sachin Pundhir, Teresa D’Altri, Coline Gentil, Manja Meggendorfer, Jürg Schwaller, Torsten Haferlach, Florian Grebien, Bo T. Porse
The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated;CEBPADM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPANT), promoting expression of the leukemia-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ec7f896c881ee6889222b0683e4e87
https://doi.org/10.1101/2023.03.28.534511
https://doi.org/10.1101/2023.03.28.534511
Autor:
Claudia Schabereiter-Gurtner, Brigitte Selitsch, Birgit Willinger, Iris Camp, Kathrin Spettel, Gabriele Manhart
Publikováno v:
Infection
Purpose Due to an increasing incidence of invasive fungal infections, the availability of reliable diagnostic tools for the fast detection of a wide spectrum of fungal pathogens is of vital importance. In this study, we aimed to conduct an extensive
Autor:
Christian Irsara, Judith Loeffler-Ragg, Gerhard Stadlmayr, Nico Lingg, Reingard Grabherr, Andreas Weinhaeusl, Robert Strassl, Jelle De Vos, Elisabeth Gludovacz, Klemens Vierlinger, Farsad Eskandary, Benjamin Dieplinger, Thomas Perkmann, Daniela Sieghart, Gabriele Manhart, Florian Grebien, Christopher Tauer, Wilhelm Gerner, Andrea Griesmacher, Gordana Wozniak-Knopp, Christoph J. Binder, Helmuth Haslacher, Monika Cserjan-Puschmann, Nicolas Marx, Juergen Mairhofer, Alexander E. Egger, Miriam Klausberger, Lisa Milchram, Gregor Hoermann, Maria Stadler, Peter Satzer, Peter Quehenberger, Gerda Leitner, Guenter Weiss, Richard Strasser, Manuela Hofer, Markus Wahrmann, Nikolaus B. Binder, Nicole Borth, Alois Jungbauer, Christoph Koeppl, Patricia Pereira Aguilar, Lukas Mach, Gerald Striedner, Rainer Hahn, Boris M. Hartmann, Margot Egger, Mark Duerkop, Florian Strobl, Rosa Bellmann-Weiler, Barbara Holzer, Clemens Gruenwald-Gruber, Marie-Kathrin Breyer, Elisabeth Laurent, Daniel Maresch, Ulrike Vavra, Jasmin Huber, Juergen Beck
Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection. While first-generation antibody tests have primarily provided qualitative results with low specificity, accurate seroprevalence studies and tracking of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b40cb3a1c8066e4d9ba8e9bf9d3f260d
https://doi.org/10.1101/2021.01.19.21249921
https://doi.org/10.1101/2021.01.19.21249921
Autor:
Miriam Klausberger, Nikolaus F. Kienzl, Gerhard Stadlmayr, Clemens Grünwald‐Gruber, Elisabeth Laurent, Katharina Stadlbauer, Florian Stracke, Klemens Vierlinger, Manuela Hofner, Gabriele Manhart, Wilhelm Gerner, Florian Grebien, Andreas Weinhäusel, Lukas Mach, Gordana Wozniak‐Knopp
Publikováno v:
Biotechnology Journal. 17:2100422
The receptor binding domain (RBD) of the SARS-CoV-2 spike (S)-protein is a prime target of virus-neutralizing antibodies present in convalescent sera of COVID-19 patients and thus is considered a key antigen for immunosurveillance studies and vaccine