Retinal Layer Separation (ReLayS) method enables the molecular analysis of photoreceptor segments and cell bodies, as well as the inner retina

Autor: Vyara Todorova, Luca Merolla, Duygu Karademir, Gabriele M. Wögenstein, Julian Behr, Lynn J. A. Ebner, Marijana Samardzija, Christian Grimm

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Understanding the physiology of the retina, and especially of the highly polarized photoreceptors, is essential not only to broaden our knowledge of the processes required for normal vision, but also to develop effective therapies to prevent

Externí odkaz: https://doaj.org/article/4755d8b2082a466ba07c645babee31e3

Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment

Autor: Raquel Casado-Polanco, Gloria Colombo, Gabriele M. Wögenstein, Margaret E. Maes, Sandra Siegert

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 210-224 (2021)
Molecular Therapy-Methods & Clinical Development

Adeno-associated viruses (AAVs) are widely used to deliver genetic material in vivo to distinct cell types such as neurons or glial cells, allowing for targeted manipulation. Transduction of microglia is mostly excluded from this strategy, likely due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4f2b5b7c11736b8d15170684e38f58
http://europepmc.org/articles/PMC8516996