Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Gabriele M. König"'
Autor:
Edda S. F. Matthees, Jenny C. Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D’Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M. König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs are classified into cytosolic GRK2/3 and membrane-tethered GRK5/6 subfamili
Externí odkaz:
https://doaj.org/article/96a45090aeee491db5f90c0458558dd1
Autor:
Jan H. Voss, Max Crüsemann, Christian R.O. Bartling, Stefan Kehraus, Asuka Inoue, Gabriele M. König, Kristian Strømgaard, Christa E. Müller
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106492- (2023)
Summary: The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gαq/11 proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, tritium-labeled YM and FR derivativ
Externí odkaz:
https://doaj.org/article/2a7281d6a7c5400a9b68ae13982ff5b1
Autor:
Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S. Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J. Simon Wiegert, Gabriele M. König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN
Externí odkaz:
https://doaj.org/article/a279b477c4f4465bb0b225dabc9ba09a
Autor:
Takefumi Kimura, Sai P. Pydi, Lei Wang, Dhanush Haspula, Yinghong Cui, Huiyan Lu, Gabriele M. König, Evi Kostenis, Gregory R. Steinberg, Oksana Gavrilova, Jürgen Wess
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Obesity impairs regulation of adipocyte lipolysis, which contributes towards development of insulin resistance. Here the authors report that adipocyte Gq signaling functions as a regulator of lipolysis and systemic glucose and lipid homeostasis in mi
Externí odkaz:
https://doaj.org/article/f0d1158d61ee4a5a901478e2a9b74e39
Autor:
Cornelia Hermes, René Richarz, Daniel A. Wirtz, Julian Patt, Wiebke Hanke, Stefan Kehraus, Jan Hendrik Voß, Jim Küppers, Tsubasa Ohbayashi, Vigneshwaran Namasivayam, Judith Alenfelder, Asuka Inoue, Peter Mergaert, Michael Gütschow, Christa E. Müller, Evi Kostenis, Gabriele M. König, Max Crüsemann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
FR900359 (FR) is a Gq protein inhibitor depsipeptide isolated from an uncultivable plant endosymbiont and synthesized by non-ribosomal peptide synthetases. Here, the authors discover a cultivable bacterial FR producer and show that FrsA thioesterase
Externí odkaz:
https://doaj.org/article/2463819dc4b944af9d1f08c6cace66cc
Autor:
Cora Hertzer, Stefan Kehraus, Nils Böhringer, Fontje Kaligis, Robert Bara, Dirk Erpenbeck, Gert Wörheide, Till F. Schäberle, Heike Wägele, Gabriele M. König
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1596-1605 (2020)
Investigations on the biochemical relationship between Doriprismatica stellata (Chromodorididae, Doridoidea) nudibranchs, their egg ribbons, and the associated dietary sponge Spongia cf. agaricina (Demospongiae, Porifera) led to the isolation of the
Externí odkaz:
https://doaj.org/article/cd68ba7be878403191815957dc90020c
Autor:
Cora Hertzer, Nani Ingrid Jacquline Undap, Adelfia Papu, Dhaka Ram Bhandari, Stefan Aatz, Stefan Kehraus, Fontje Kaligis, Robert Bara, Till F. Schäberle, Heike Wägele, Gabriele M. König
Publikováno v:
Diversity, Vol 15, Iss 2, p 304 (2023)
Five Chromodoris species from North Sulawesi, Indonesia, were investigated for their sequestration of marine natural products. The cytotoxic 2-thiazolidinone macrolide latrunculin A (LatA) was the major metabolite in all examined Chromodoris species,
Externí odkaz:
https://doaj.org/article/311e9b5cea7c4d7c8d661618df594ec4
Autor:
Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S. Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J. Simon Wiegert, Gabriele M. König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/8eaba225fb6a43418e646ee10581c265
Autor:
Liu Liu, Diptadip Dattaroy, Katherine F. Simpson, Luiz F. Barella, Yinghong Cui, Yan Xiong, Jian Jin, Gabriele M. König, Evi Kostenis, Jefferey C. Roman, Klaus H. Kaestner, Nicolai M. Doliba, Jürgen Wess
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining euglycemia. New insights into the signaling pathways that control glucagon secretion may stimulate the development of novel therapeutic agents. In this study, we i
Externí odkaz:
https://doaj.org/article/c38dd95266e54296ab7d20f538d7f6e4
Autor:
Jan H. Voss, Haneen Al-Hroub, Robin Gedschold, Jennifer M. Dietrich, Evelyn Gaffal, Marieta Toma, Stefan Kehraus, Gabriele M. König, Peter Brust, Bernd K. Fleischmann, Daniela Wenzel, Winnie Deuther-Conrad, Christa E. Müller
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 57 (2022)
G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies suggested G proteins as novel drug targets for the treatment of complex diseases, e.g., as
Externí odkaz:
https://doaj.org/article/ab51b259cd79400aa01e768efdd94017