Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Gabriele Ludewig"'
Autor:
Farrukh Aqil, Hua Shen, Jeyaprakash Jeyabalan, Xing Xin, Hans-Joachim Lehmler, Gabriele Ludewig, Larry W. Robertson, Ramesh C. Gupta
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 820-833 (2014)
A new delivery method via polymeric implants was used for continuous exposure to PCBs. Female Sprague-Dawley rats received subcutaneous polymeric implants containing PCB126 (0.15% load), PCB153 (5% load), or both, for up to 45 d and release kinetics
Externí odkaz:
https://doaj.org/article/e3034141c7cf400a8b0e5a4508bff380
Autor:
Chun-Yun Zhang, Xueshu Li, Susanne Flor, Patricia Ruiz, Anneli Kruve, Gabriele Ludewig, Hans-Joachim Lehmler
Publikováno v:
Environmental Science & Technology. 56:12460-12472
Lower chlorinated polychlorinated biphenyls (LC-PCBs) and their metabolites make up a class of environmental pollutants implicated in a range of adverse outcomes in humans; however, the metabolism of LC-PCBs in human models has received little attent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b17c56d7928702c40295971bfb9ff11
https://doi.org/10.1021/acs.est.2c03687
https://doi.org/10.1021/acs.est.2c03687
Publikováno v:
Environmental Science & Technology
The characterization of the metabolism of lower chlorinated PCB, such as 4-chlorobiphenyl (PCB3), is challenging because of the complex metabolite mixtures formed in vitro and in vivo. We performed parallel metabolism studies with PCB3 and its hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63f35ec51465442dc5a46b47b5b5c67
https://doi.org/10.1021/acs.est.1c01076
https://doi.org/10.1021/acs.est.1c01076
Autor:
Taehyun Roh, Peter S. K. Knappett, Daikwon Han, Gabriele Ludewig, Kevin M. Kelly, Kai Wang, Peter J. Weyer
Publikováno v:
International Journal of Environmental Research and Public Health; Volume 20; Issue 7; Pages: 5397
Arsenic and atrazine are two water contaminants of high public health concern in Iowa. The occurrence of arsenic and atrazine in drinking water from Iowa’s private wells and public water systems was investigated over several decades. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdbb3f8455368d09750c04d02580e0a
https://doi.org/10.3390/ijerph20075397
https://doi.org/10.3390/ijerph20075397
Autor:
Katherine N. Gibson-Corley, Nazmin Eti, Regan L. Scott, Violet E Klenov, Michael J. Soares, Khursheed Iqbal, Gabriele Ludewig, Susanne Flor, Larry W. Robertson
Publikováno v:
Toxicology
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the regulation of biological responses to more planar aromatic hydrocarbons, like TCDD. We previously described the sequence of events following exposure of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe38a24137ed615df65f511e04398dc1
https://europepmc.org/articles/PMC8748418/
https://europepmc.org/articles/PMC8748418/
Autor:
Malavika K. Adur, Gabriele Ludewig, Aileen F. Keating, Jason W. Ross, Michael J. Soares, Nazmin Eti, Larry W. Robertson, Susanne Flor, Violet E Klenov, Khursheed Iqbal, Shanthi Ganesan
Publikováno v:
Toxicol Appl Pharmacol
Polychlorinated biphenyls (PCBs) are endocrine disrupting chemicals with documented, though mechanistically ill-defined, reproductive toxicity. The toxicity of dioxin-like PCBs, such as PCB126, is mediated via the aryl hydrocarbon receptor (AHR) in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503c343bbc00e76cc6232115fb2b45ac
https://pubmed.ncbi.nlm.nih.gov/34256052
https://pubmed.ncbi.nlm.nih.gov/34256052
Publikováno v:
Environ Sci Technol
Cell culture models are used to study the toxicity of polychlorinated biphenyls (PCBs); however, it is typically unknown how much PCB enters the cells and, for chiral PCBs, if the partitioning is atropselective. We investigated the partitioning of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17218af8e9430a41346bc701de705033
https://pubmed.ncbi.nlm.nih.gov/33059451
https://pubmed.ncbi.nlm.nih.gov/33059451
Autor:
Chun-Yun Zhang, Ram Dhakal, Susanne Flor, Lynn M. Teesch, Xin Hu, Patricia Ruiz, Hans-Joachim Lehmler, Gabriele Ludewig
Publikováno v:
Environ Sci Technol
3,3’-Dichlorobiphenyl (PCB 11) is a byproduct of industrial processes and detected in environmental samples. PCB 11 and its metabolites are present in human serum, and emerging evidence demonstrates that PCB 11 is a developmental neurotoxicant. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1302516cb9f789be510ccb3bb9608660
https://pubmed.ncbi.nlm.nih.gov/32910851
https://pubmed.ncbi.nlm.nih.gov/32910851
We investigated the partitioning of chiral PCBs (PCB 91, PCB 95, PCB 132, or PCB 136) in the human hepatoma HepG2 cell line and used a computational model for the in vitro to in vivo extrapolation (IVIVE) of PCB levels. HepG2 cells were incubated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22114bed5427033bbce317da1a851241
https://doi.org/10.26434/chemrxiv.12126684
https://doi.org/10.26434/chemrxiv.12126684
Publikováno v:
Geological Society of America Abstracts with Programs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ec2875dbc753a4c4312415059795bb8
https://doi.org/10.1130/abs/2020am-359868
https://doi.org/10.1130/abs/2020am-359868