Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gabriele La Monica"'
Autor:
Gabriele La Monica, Giuseppe Pizzolanti, Concetta Baiamonte, Alessia Bono, Federica Alamia, Francesco Mingoia, Antonino Lauria, Annamaria Martorana
Publikováno v:
ACS Omega, Vol 8, Iss 38, Pp 34640-34649 (2023)
Externí odkaz:
https://doaj.org/article/e90612052424426d928f071e5ce8f93c
Publikováno v:
Molecules, Vol 29, Iss 12, p 2813 (2024)
Aurones, particular polyphenolic compounds belonging to the class of minor flavonoids and overlooked for a long time, have gained significative attention in medicinal chemistry in recent years. Indeed, considering their unique and outstanding biologi
Externí odkaz:
https://doaj.org/article/2560a09736724409adc48b7ae8e6dd47
Autor:
Gabriele La Monica, Giuseppe Pizzolanti, Concetta Baiamonte, Alessia Bono, Federica Alamia, Francesco Mingoia, Antonino Lauria, Annamaria Martorana
Publikováno v:
ACS Omega, Vol 8, Iss 50, Pp 48582-48582 (2023)
Externí odkaz:
https://doaj.org/article/7fffe6c7837a4bf588b84515d66b59be
Autor:
Alessia Bono, Gabriele La Monica, Federica Alamia, Francesco Mingoia, Carla Gentile, Daniele Peri, Antonino Lauria, Annamaria Martorana
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13769 (2023)
CDK-1 and PARP-1 play crucial roles in breast cancer progression. Compounds acting as CDK-1 and/or PARP-1 inhibitors can induct cell death in breast cancer with a selective synthetic lethality mechanism. A mixed treatment by means of CDK-1 and PARP-1
Externí odkaz:
https://doaj.org/article/addcda9d687447fe82667185c1d42872
Autor:
Alessia Bono, Antonino Lauria, Gabriele La Monica, Federica Alamia, Francesco Mingoia, Annamaria Martorana
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8377 (2023)
The viral main protease is one of the most attractive targets among all key enzymes involved in the life cycle of SARS-CoV-2. Considering its mechanism of action, both the catalytic and dimerization regions could represent crucial sites for modulatin
Externí odkaz:
https://doaj.org/article/197b73dfcb8f4baeaf31134222a449d7
Autor:
Annamaria Martorana, Gabriele La Monica, Alessia Bono, Salvatore Mannino, Silvestre Buscemi, Antonio Palumbo Piccionello, Carla Gentile, Antonino Lauria, Daniele Peri
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14374 (2022)
In vitro antiproliferative assays still represent one of the most important tools in the anticancer drug discovery field, especially to gain insights into the mechanisms of action of anticancer small molecules. The NCI-DTP (National Cancer Institute
Externí odkaz:
https://doaj.org/article/fa06fb90678c40adaf9b6f98aa778919
Autor:
Antonino Lauria, Gabriele La Monica, Alessio Terenzi, Giuseppe Mannino, Riccardo Bonsignore, Alessia Bono, Anna Maria Almerico, Giampaolo Barone, Carla Gentile, Annamaria Martorana
Publikováno v:
Molecules, Vol 26, Iss 14, p 4309 (2021)
Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation proces
Externí odkaz:
https://doaj.org/article/998bf8f2183a4abd94326f12ef0f8db3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6070 (2021)
The approval of the first HIV-1 protease inhibitors (HIV-1 PRIs) marked a fundamental step in the control of AIDS, and this class of agents still represents the mainstay therapy for this illness. Despite the undisputed benefits, the necessary lifelon
Externí odkaz:
https://doaj.org/article/fe620d95325a4e709e401522d28e16f0
Autor:
Antonino Lauria, Annamaria Martorana, Gabriele La Monica, Salvatore Mannino, Giuseppe Mannino, Daniele Peri, Carla Gentile
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3714 (2021)
The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as Cdc25 modulators by applying a mixed
Externí odkaz:
https://doaj.org/article/5b69229387fb416e869b782430d791f9
Publikováno v:
Molecules, Vol 25, Iss 18, p 4279 (2020)
The quinoline ring system has long been known as a versatile nucleus in the design and synthesis of biologically active compounds. Currently, more than one hundred quinoline compounds have been approved in therapy as antimicrobial, local anaesthetic,
Externí odkaz:
https://doaj.org/article/bc2c4ff24b654924bb23a5b18ba766fa