Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Gabriele Holtappels"'
Autor:
Olga Krysko, Darya Korsakova, Andrea Teufelberger, Amse De Meyer, Jill Steels, Natalie De Ruyck, Judith van Ovost, Sharon Van Nevel, Gabriele Holtappels, Frauke Coppieters, Mikhail Ivanchenko, Harald Braun, Maria Vedunova, Dmitri V. Krysko, Claus Bachert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundRecent in vitro studies strongly implicated mast cell-derived proteases as regulators of IL-33 activity by enzymatic cleavage in its central domain. A better understanding of the role of mast cell proteases on IL-33 activity in vivo is need
Externí odkaz:
https://doaj.org/article/6dd9876d8f9f45ccb13d05891dad68e4
Publikováno v:
Clinical and Translational Allergy, Vol 10, Iss 1, Pp 1-4 (2020)
Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy an
Externí odkaz:
https://doaj.org/article/800c11d08e374be98a00e3af54d42831
Autor:
Sharon Van Nevel, Judith van Ovost, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Harald Braun, Tania Maes, Claus Bachert, Olga Krysko
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS). The presence of neutrophils in the airways is often associated wi
Externí odkaz:
https://doaj.org/article/8a2df2b4af6d4b32b91c39f9421dbabb
Autor:
Andrea R. Teufelberger, Sharon Van Nevel, Paco Hulpiau, Maria Nordengrün, Savvas N. Savvides, Sarah De Graeve, Srinivas Akula, Gabriele Holtappels, Natalie De Ruyck, Wim Declercq, Peter Vandenabeele, Lars Hellman, Barbara M. Bröker, Dmitri V. Krysko, Claus Bachert, Olga Krysko
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Staphylococcus aureus (S. aureus) can secrete a broad range of virulence factors, among which staphylococcal serine protease-like proteins (Spls) have been identified as bacterial allergens. The S. aureus allergen serine protease-like protein D (SplD
Externí odkaz:
https://doaj.org/article/b92a45f16ebf47ce8003fcca8350dcd9
Autor:
Jonas Eckrich, Julia Hinkel, Anna Fischl, Eva Herrmann, Gabriele Holtappels, Claus Bachert, Stefan Zielen
Publikováno v:
World Allergy Organization Journal, Vol 13, Iss 6, Pp 100129- (2020)
Purpose: The prevalence of ''ocal allergic rhinitis'' within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a pot
Externí odkaz:
https://doaj.org/article/99b41d75b3314c1f81a0db17622cb194
Autor:
Takayuki Sejima, Gabriele Holtappels, Hisashi Kikuchi, Shoichiro Imayoshi, Keiichi Ichimura, Claus Bachert
Publikováno v:
Allergology International, Vol 61, Iss 1, Pp 115-122 (2012)
Background: Chronic rhinosinusitis (CRS) is classified in CRS without nasal polyp (CRSsNP) and CRS with nasal polyp (CRSwNP) in western countries, whereas this classification was not common so far in Japan. Studying inflammatory mediators in clearly
Externí odkaz:
https://doaj.org/article/feee769fd20b45059bced3ea2b949c2d
Autor:
Ilse M Beck, Koen Van Crombruggen, Gabriele Holtappels, François Daubeuf, Nelly Frossard, Claus Bachert, Karolien De Bosscher
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123068 (2015)
BACKGROUND:Glucocorticoid Receptor agonists, particularly classic glucocorticoids, are the mainstay among treatment protocols for various chronic inflammatory disorders, including nasal disease. To steer away from steroid-induced side effects, novel
Externí odkaz:
https://doaj.org/article/724fcfb63e25415990de787bf7b23af8
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136068 (2015)
Chronic rhinosinusitis is a multifactorial process disease in which bacterial infection or colonization may play an important role in the initiation or persistence of inflammatory response. The association between mucosal bacteria presence and inflam
Externí odkaz:
https://doaj.org/article/2aecc8d5c79f48888822828094d3aff9
Autor:
Lara Derycke, Stefanie Eyerich, Koen Van Crombruggen, Claudina Pérez-Novo, Gabriele Holtappels, Natalie Deruyck, Philippe Gevaert, Claus Bachert
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97581 (2014)
In chronic rhinosinusitis (CRS) different phenotypes have been reported based on cytokine profile and inflammatory cell patterns. The aim of this study was to characterize the intracytoplasmatic cytokines of T cells infiltrating the inflamed sinonasa
Externí odkaz:
https://doaj.org/article/0456ba3a42724dda89051f78eac117c1
Autor:
Nan Zhang, Koen Van Crombruggen, Gabriele Holtappels, Feng Lan, Michail Katotomichelakis, Luo Zhang, Petra Högger, Claus Bachert
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93754 (2014)
BACKGROUND: Topical glucocorticosteroids are the first line therapy for airway inflammation. Modern compounds with higher efficacy have been developed, but head-to-head comparison studies are sparse. OBJECTIVE: To compare the activity of two intranas
Externí odkaz:
https://doaj.org/article/33844adefff442279580c72640fc097d