Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gabriele Hessler"'
Autor:
Eyad Naser, Stephanie Kadow, Fabian Schumacher, Zainelabdeen H. Mohamed, Christian Kappe, Gabriele Hessler, Barbara Pollmeier, Burkhard Kleuser, Christoph Arenz, Katrin Anne Becker, Erich Gulbins, Alexander Carpinteiro
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 896-910 (2020)
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific AS
Externí odkaz:
https://doaj.org/article/5e9c3b6587c9418bb93a4e4217043165
Autor:
Stephanie Kadow, Fabian Schumacher, Melanie Kramer, Gabriele Hessler, René Scholtysik, Sara Oubari, Patricia Johansson, Andreas Hüttmann, Hans Christian Reinhardt, Burkhard Kleuser, Mario Zoratti, Andrea Mattarei, Ildiko Szabò, Erich Gulbins, Alexander Carpinteiro
Publikováno v:
Cancers, Vol 14, Iss 8, p 1955 (2022)
Despite several new developments in the treatment of multiple myeloma, all available therapies are only palliative without curative potential and all patients ultimately relapse. Thus, novel therapeutic options are urgently required to prolong surviv
Externí odkaz:
https://doaj.org/article/d941a1009a9f4051bbbe23732da8d1d0
Autor:
Alexander Carpinteiro, Nadine Beckmann, Aaron Seitz, Gabriele Hessler, Barbara Wilker, Matthias Soddemann, Iris Helfrich, Bärbel Edelmann, Erich Gulbins, Katrin Anne Becker
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 1, Pp 1-14 (2016)
Background: Hematogenous metastasis of malignant tumor cells is a multistep process that requires release of tumor cells from the local tumor mass, interaction of the tumor cells with platelets in the blood, and adhesion of either the activated tumor
Externí odkaz:
https://doaj.org/article/917828e495f641b58809e7996a3919a0
Autor:
Nadine Beckmann, Katrin Anne Becker, Silke Walter, Jan U. Becker, Melanie Kramer, Gabriele Hessler, Stefanie Weber, Joachim R. Göthert, Klaus Fassbender, Erich Gulbins, Alexander Carpinteiro
Publikováno v:
Cellular Physiology and Biochemistry, Vol 43, Iss 4, Pp 1-1 (2017)
Background/Aims: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. Me
Externí odkaz:
https://doaj.org/article/c32f3f2b8f5946a0b61eea168f4e802d
Autor:
Burkhard Kleuser, Eyad Naser, Christian Kappe, Barbara Pollmeier, Fabian Schumacher, Gabriele Hessler, Katrin Anne Becker, Alexander Carpinteiro, Zainelabdeen H. Mohamed, Stephanie Kadow, Erich Gulbins, Christoph Arenz
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 61, Iss 6, Pp 896-910 (2020)
Journal of Lipid Research, Vol 61, Iss 6, Pp 896-910 (2020)
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific AS
Autor:
Alexander Carpinteiro, Constantin Adams, Melanie Kramer, Katrin Anne Becker, Nadine Beckmann, Gabriele Hessler, Erich Gulbins
Metastatic dissemination of cancer cells is one of the hallmarks of malignancy and accounts for approximately 90 % of human cancer deaths. Within the blood vasculature, tumor cells may aggregate with platelets to form clots, adhere to and spread onto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604776461b35d220773f740b0faabb33
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=84991387203
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=84991387203
Autor:
Matthias Soddemann, Nadine Beckmann, Katrin Anne Becker, Aaron P. Seitz, Alexander Carpinteiro, Iris Helfrich, Erich Gulbins, Barbara Wilker, Bärbel Edelmann, Gabriele Hessler
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 1, Pp 1-14 (2016)
Background: Hematogenous metastasis of malignant tumor cells is a multistep process that requires release of tumor cells from the local tumor mass, interaction of the tumor cells with platelets in the blood, and adhesion of either the activated tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedc06033a02b79cd4f53d12bda71998
https://www.ncbi.nlm.nih.gov/pubmed/26741636
https://www.ncbi.nlm.nih.gov/pubmed/26741636
Autor:
Iris Helfrich, Stefan P. Müller, Alexander Carpinteiro, Heike Grassmé, Burkhard Kleuser, Erich Gulbins, Simone Keitsch, Miroslava Požgajová, Constantin Adams, Michael J. Edwards, Kurt Werner Schmid, Lukasz Japtok, Gabriele Hessler, Katrin Anne Becker
Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb5a215e6a74a55d1081ff0939e5a7e
Autor:
Gabriele Hessler, Creg J. Workman, John E. Goodall, Dario A. A. Vignali, Stephen P. Young, Leigh D Church, David A. Rider, Erich Gulbins, Paul A. Bacon
Publikováno v:
Journal of Leukocyte Biology. 78:266-278
Tumor necrosis factor alpha (TNF-alpha) is a potent, pleiotrophic cytokine, which is proinflammatory but can also suppress T lymphocyte function. In chronic inflammatory disease such as rheumatoid arthritis, exposure of T cells to TNF-alpha alters th
Publikováno v:
Fas Signaling ISBN: 9780387321721
Recent studies indicate that the reorganization of receptor molecules in distinct domains of the cell membrane constitutes an important and general mechanism that is required for the initiation of signaling via various receptor molecules. Studies on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6e04fd76bb791cf77e145ebf2cd6560
https://doi.org/10.1007/0-387-34573-6_3
https://doi.org/10.1007/0-387-34573-6_3