Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gabriele Hübinger"'
Autor:
Susanne Mühlbacher, Hanno Roder, R. Paul Fracasso, Sylvie LeCorre, Gabriele Hübinger, Hans Klafki, Fred Hoffman, Silvia Geis, Sandra Gordon, Sandrine Ferrand
Publikováno v:
University of Copenhagen
Abnormal hyperphosphorylation of tau is believed to constitute a critical biochemical event in the process of neu- rofibrillary degeneration of Alzheimer's disease. We have developed a cellular model where apparently authentic PHF-like tau hyperphosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b189875db7e12d3667b4c92c4035022
https://doi.org/10.3233/jad-2008-13306
https://doi.org/10.3233/jad-2008-13306
Publikováno v:
Experimental Hematology. 31:226-233
Objective Approximately 60% of all anaplastic large-cell lymphomas (ALCL) contain a specific t(2;5)(p23;q35) chromosomal translocation leading to overexpression of NPM-ALK. As the chimeric tyrosine kinase is involved in tumorigenesis and pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bfed8e1564358d74b804e627c9df6d
https://doi.org/10.1016/s0301-472x(02)01084-6
https://doi.org/10.1016/s0301-472x(02)01084-6
Autor:
T Hecker, Gabriele Hübinger, W Rittgen, M Wölfle, Lothar Bergmann, T. Karakas, Carsten Schwänen
Publikováno v:
Leukemia. 16:2096-2105
Bendamustine is a novel cytostatic agent, with activity in non-Hodgkin's lymphomas including B-chronic lymphocytic leukemia (B-CLL). The knowledge about its mode of action, however, is still limited. Here, we investigated the in vitro ability of bend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea56c4156fb87f6781bf241dcc36aca6
https://doi.org/10.1038/sj.leu.2402651
https://doi.org/10.1038/sj.leu.2402651
Autor:
Jochen Graf, Eberhard Hildt, Lothar Bergmann, Elke Müller, Bernhard B. Singer, Gabriele Hübinger, Inka Scheffrahn, Christof Schneider, Irmgard Sigg
Publikováno v:
Oncogene. 20:590-598
One of the major characteristics of anaplastic large cell lymphomas (ALCL) is the expression of the Ki-1/CD30 antigen. While the receptor mediates NF-kappaB-activation in Hodgkin's lymphomas, some data suggest the CD30-mediated apoptosis of other CD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4257230030ce2353d09e5319d8d97260
https://doi.org/10.1038/sj.onc.1204128
https://doi.org/10.1038/sj.onc.1204128
Autor:
Gabriele Hübinger, Frederic Jehan, Christoph Englert, Ulrich Maurer, Eckhart Weidmann, Hector F. DeLuca, Lothar Bergmann
Publikováno v:
Journal of Biological Chemistry. 276:3727-3732
The Wilms' tumor gene (wt1) encodes a transcription factor involved in urogenital development, in particular in renal differentiation, and in hematopoietic differentiation. Differentiation of a number of solid tumor and leukemic cells lines can be me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8892f81f7c25220365934aee789e87
https://doi.org/10.1074/jbc.m005292200
https://doi.org/10.1074/jbc.m005292200
Autor:
Mike Hutton, Hanno Roder, Barbara Monse, Gabriele Hübinger, Cynthia Zehr, Jason L. Eriksen, Nikolaus Plesnila, Sylvie Le Corre, Mei Yue, Heidi Sahagún, Hans Klafki, Eileen McGowan, Jada Lewis, Dennis W. Dickson, Axel Obermeier, Pierfausto Seneci
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(25)
An orally bioavailable and blood–brain barrier penetrating analog of the kinase inhibitor K252a was able to prevent the typical motor deficits in the tau (P301L) transgenic mouse model (JNPL3) and markedly reduce soluble aggregated hyperphosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a0b57f2fa66f63e05eb8af649d2c17
https://pubmed.ncbi.nlm.nih.gov/16769887
https://pubmed.ncbi.nlm.nih.gov/16769887
Publikováno v:
Leukemialymphoma. 45(5)
Expression of the cytokine receptor CD30 is a characteristic feature of anaplastic large cell lymphoma (ALCL). Reports regarding CD30-mediated signaling in ALCL cells are highly controversial, especially with respect to the regulation of cell surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45e91a858f8a9f8322985427ada50af
https://pubmed.ncbi.nlm.nih.gov/15291361
https://pubmed.ncbi.nlm.nih.gov/15291361
Autor:
Elke Müller, Gabriele Hübinger, Carsten Schwänen, Mathias Schmid, Dieter Kirchner, Lothar Bergmann, Heike Ruff, Christof Schneider, Dagmar Stöhr
Publikováno v:
Experimental hematology. 32(4)
Objective Expression of the cytokine receptor CD30 is a typical feature of anaplastic large cell lymphomas (ALCL). CD30-induced effects have a great impact on cell activation and viability. Materials and methods Using Karpas 299 cells, we performed d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d5d4bceb3b4831b072e8e822b8ca5f
https://pubmed.ncbi.nlm.nih.gov/15050749
https://pubmed.ncbi.nlm.nih.gov/15050749
Autor:
Gabriele Hübinger, Christof Schneider
Publikováno v:
Leukemialymphoma. 43(7)
CD30, a member of the tumor necrosis factor receptor (TNFR) family, is a characteristic cell surface receptor for activated T-cells and the malignant cells of Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and a few other non-Hodgkin's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957475b6f6ebaec5c0d32e3fa510c611
https://pubmed.ncbi.nlm.nih.gov/12389614
https://pubmed.ncbi.nlm.nih.gov/12389614
Publikováno v:
Experimental hematology. 29(10)
Objective The Wilms' tumor gene product (WT1) was identified as a tumor suppressor in pediatric kidney tumors. Conversely, acute leukemias express WT1 at a high frequency, and leukemias with high levels of WT1 expressed by leukemic blast cells have a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dbf21802af7833b353d2e7f8a4c7eb
https://pubmed.ncbi.nlm.nih.gov/11602325
https://pubmed.ncbi.nlm.nih.gov/11602325