Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Gabriele Fendrich"'
Autor:
Sandra W. Cowan-Jacob, Wolfgang Jahnke, Stephan Grzesiek, Navratna Vajpai, André Strauss, Paul W. Manley, Gabriele Fendrich
Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f54faaa5d3e8dddcafdadcaaf70e802
http://doc.rero.ch/record/314158/files/12104_2008_Article_9079.pdf
http://doc.rero.ch/record/314158/files/12104_2008_Article_9079.pdf
Autor:
Ralf Glatthar, John E. Peel, Henri Mattes, Gabriele Fendrich, Helmut Sparrer, Henrik Möbitz, Jeff Hornfeld, Rene Beerli, Peter Drückes, Fiona Spence, Aleksandar Stojanovic, Ernst Gassmann, Georg Martiny-Baron, Troxler Thomas J, Joachim Blanz, Sascha Gutmann
Publikováno v:
Journal of medicinal chemistry. 59(16)
Cancer Osaka thyroid (COT) kinase is an important regulator of pro-inflammatory cytokines in macrophages. Thus, pharmacologic inhibition of COT should be a valid approach to therapeutically intervene in the pathogenesis of macrophage-driven inflammat
Autor:
Simona Cotesta, André Strauss, Jürgen Mestan, Xavier Pelle, Sandra W. Cowan-Jacob, Andreas Marzinzik, Wolfgang Jahnke, Pascal Furet, Robert Martin Grotzfeld, Doriano Fabbro, Gabriele Fendrich
Publikováno v:
Journal of the American Chemical Society. 132:7043-7048
Allosteric inhibitors of Bcr-Abl have emerged as a novel therapeutic option for the treatment of CML. Using fragment-based screening, a search for novel Abl inhibitors that bind to the myristate pocket was carried out. Here we show that not all myris
Autor:
Francisco Adrian, Janis Liebetanz, André Strauss, Sandra W. Cowan-Jacob, Andreas Marzinzik, Xavier Pelle, Pascal Furet, Frederic Berst, Jürgen Mestan, Paul W. Manley, Gabriele Fendrich, Robert Martin Grotzfeld, Nathanael S. Gray, Markus Warmuth, Doriano Fabbro, Jianming Zhang, Alexandra Szyttenholm, Wolfgang Jahnke
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:454-462
The ATP-competitive inhibitors dasatinib and nilotinib, which bind to catalytically different conformations of the Abl kinase domain, have recently been approved for the treatment of imatinib-resistant CML. These two new drugs, albeit very efficient
Autor:
Roxana E. Iacob, Wolfgang Jahnke, John R. Engen, Paul W. Manley, Guoxun Liu, Markus Warmuth, Badry Bursulaya, Gabriele Fendrich, Taebo Sim, Xianming Deng, Jianming Zhang, Francisco Adrian, Mohammad Azam, Barun Okram, Christine Dierks, Stephan Grzesiek, Navratna Vajpai, Yi Liu, Fangxian Sun, John T. Powers, Allen G. Li, Nathanael S. Gray, George Q. Daley, André Strauss, Sandra W. Cowan-Jacob, Gui Rong Guo, Qiang Ding, Tove Tuntland, Amy Wojciechowski, Yongmun Choi
Publikováno v:
Nature. 463:501-506
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr-Abl, we recently reported the discovery of GNF-2, a selective allosteric Bcr-Abl inhibitor. Here, using solution NMR, X-ray crystallograp
Publikováno v:
Protein Expression and Purification. 64:185-193
The recombinant expression of eukaryotic proteins in Escherichia coli often results in protein aggregation. Several articles report on improved solubility and increased purification yields of individual proteins upon over-expression of E. coli chaper
Autor:
Stephan Grzesiek, Sandra W. Cowan-Jacob, Navratna Vajpai, Wolfgang Jahnke, Gabriele Fendrich, Paul W. Manley, André Strauss
Publikováno v:
Journal of Biological Chemistry. 283:18292-18302
Current structural understanding of kinases is largely based on x-ray crystallographic studies, whereas very little data exist on the conformations and dynamics that kinases adopt in the solution state. ABL kinase is an important drug target in the t
Autor:
Michel A. Horisberger, André Strauss, Gabriele Fendrich, Bernd Meyhack, Janis Liebetanz, Jean-Marc Schlaeppi, Rita Schmitz
Publikováno v:
Protein Expression and Purification. 56:167-176
As exemplified by three cases, we show that the addition of a small molecular weight inhibitor to the culture of Baculovirus-infected insect cells can dramatically improve the expression of a recombinant kinase. The expression of the tyrosine kinase
Autor:
Niko Schmiedeberg, Gabriele Fendrich, Ralf Glatthar, Henrik Möbitz, André Strauss, Sascha Gutmann, Silvio Ofner, Peter Drückes, Sylvie Antz, Aleksandar Stojanovic, Helmut Sparrer, S. Rieffel, Henri Mattes, Alexandra Hinniger, Troxler Thomas J
Publikováno v:
The Journal of biological chemistry. 290(24)
Macrophages are important cellular effectors in innate immune responses and play a major role in autoimmune diseases such as rheumatoid arthritis. Cancer Osaka thyroid (COT) kinase, also known as mitogen-activated protein kinase kinase kinase 8 (MAP3
Autor:
Sandra W. Cowan-Jacob, Pascal Furet, Doriano Fabbro, Gabriele Fendrich, Paul Rheinberger, Gabriele Rummel, Paul W. Manley, Andreas Floersheimer, Mario Centeleghe, Janis Liebetanz
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
A case study showing how the determination of multiple cocrystal structures of the protein tyrosine kinase c-Abl was used to support drug discovery, resulting in a compound effective in the treatment of chronic myelogenous leukaemia.
Chronic mye
Chronic mye