Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gabriele E. Sonnenberg"'
Autor:
Chay Ngee Lim, Constantino Kantaridis, Isabelle Huyghe, Donal Gorman, Stephen Berasi, Gabriele E. Sonnenberg
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Proteinuria associated with podocyte effacement is a hallmark of focal segmental glomerulosclerosis (FSGS). Preclinical studies implicated ROBO2/SLIT2 signaling in the regulation of podocyte adhesion, and inhibition of this pathway is a nove
Externí odkaz:
https://doaj.org/article/64976c4a18ce4ca2ad64a7b9bb8b7c3f
Autor:
Gabriele E. Sonnenberg, Glenn R. Krakower, Lisa J. Martin, Michael Olivier, Anne E. Kwitek, Anthony G. Comuzzie, John Blangero, Ahmed H. Kissebah
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 4, Pp 610-615 (2004)
In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize q
Externí odkaz:
https://doaj.org/article/17d95891181b4512b0b0ab78d9c0c8fb
Autor:
David A. Beebe, Gregg D. Cappon, Michelle Clasquin, Marc K. Hellerstein, Norimitsu Shirai, William J. Reagan, Zhongyuan Sun, Katherine Hales, Gabriele E. Sonnenberg, Jeffrey A. Pfefferkorn, Theodore J. Schmahai, Nicholas B. Vera, Marcy Matthews, Trenton T. Ross, Clare Buckeridge, Enida Ziso Qejvanaj, Kenneth L. Kelly, Shoh Asano, Santos Carvajal-Gonzalez, William P. Esler, Paul A. Amor, Kelvin W. Li, Arthur Bergman
Publikováno v:
Nature Metabolism. 2:1163-1178
Acetyl-CoA carboxylase (ACC) catalyses the first step of de novo lipogenesis (DNL). Pharmacologic inhibition of ACC has been of interest for therapeutic intervention in a wide range of diseases. We demonstrate here that ACC and DNL are essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37212bb75eaf160e3e8857af5cd7c6c9
https://doi.org/10.1038/s42255-020-00272-9
https://doi.org/10.1038/s42255-020-00272-9
Autor:
Isabelle Huyghe, Stephen P. Berasi, Chay Ngee Lim, Donal Gorman, Gabriele E. Sonnenberg, Constantino Kantaridis
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Proteinuria associated with podocyte effacement is a hallmark of focal segmental glomerulosclerosis (FSGS). Preclinical studies implicated ROBO2/SLIT2 signaling in the regulation of podocyte adhesion, and inhibition of this pathway is a novel target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f93bebfc41220434284c94f0a9e8a2
http://europepmc.org/articles/PMC8351251
http://europepmc.org/articles/PMC8351251
Autor:
Gabriele E. Sonnenberg, Collin Crowley, Trenton T. Ross, Michelle Clasquin, Arthur Bergman, Anu Nigam, Yan Weng, Derek M. Erion, Kou Kou, Morris J. Birnbaum, Gang Xing, Nicholas B. Vera, Kristin Chidsey, Veena Somayaji, William P. Esler, Jemy A. Gutierrez, Richard Allen, Kendra K. Bence, Jeffrey A. Pfefferkorn, Magee Thomas Victor, Sylvie Perez, Matt Blatnik, Gregory J. Tesz, Melissa A. Fulham, Wei Liu
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 48, Iss, Pp 101196-(2021)
Molecular Metabolism, Vol 48, Iss, Pp 101196-(2021)
Objective Recent studies suggest that excess dietary fructose contributes to metabolic dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, thereby increasing the risk of obesity, type 2 diabetes (T2D), non-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9832276149b62b82c13f9550e053414
https://doi.org/10.1016/j.molmet.2021.101196
https://doi.org/10.1016/j.molmet.2021.101196
Autor:
Gabriele E. Sonnenberg, V. Margaret Jackson, William S. Denney, Theresa Tuthill, Santos Carvajal-Gonzalez
Publikováno v:
British Journal of Clinical Pharmacology. 83:326-338
Aim To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. Methods Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-bli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60be0b132f70734931307912b51f710b
https://doi.org/10.1111/bcp.13127
https://doi.org/10.1111/bcp.13127
Autor:
Jeffrey A. Pfefferkorn, Matthew Gorgoglione, Scott M. Turner, Clare Buckeridge, Nicholas B. Vera, Marc K. Hellerstein, Annette M. Silvia, Gabriele E. Sonnenberg, Santos Carvajal-Gonzalez, Kathleen Biddle, Paul A. Amor, Raja K Sivamani, Lauren A Hassoun, David A. Griffith, Carine Beysen, Steven M. Watkins, Timothy P. Rolph, Julie Purkal, Mark Fitch, Gregory J. Tesz, William P. Esler, Frank J. Geoly, Suzana S. Bosanac
Publikováno v:
Science translational medicine. 11(492)
Sebum plays important physiological roles in human skin. Excess sebum production contributes to the pathogenesis of acne vulgaris, and suppression of sebum production reduces acne incidence and severity. We demonstrate that sebum production in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed755d8f32090787a27b2b7eaeec5c2b
https://pubmed.ncbi.nlm.nih.gov/31092695
https://pubmed.ncbi.nlm.nih.gov/31092695
Autor:
Laurel Sweet, Carine Beysen, William P. Esler, David Price, Alan M. Mathiowetz, David A. Griffith, Daniel W. Kung, Scott W. Bagley, Scott M. Turner, Gabriele E. Sonnenberg, Eric Ravussin, Santos Carvajal-Gonzalez, Felix Vajdos, Chris Limberakis, James A. Southers, Paul A. Amor, Shawn D. Doran, Kirk McPherson
Publikováno v:
Journal of Medicinal Chemistry
Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer. However, the identification of tool compounds suitable to test the hypothesis in human trials has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1aef7fc28748a6cde4608945069cb34
http://europepmc.org/articles/PMC4281100
http://europepmc.org/articles/PMC4281100
Autor:
Yi Zhang, Ann DeLaForest, Gabriele E. Sonnenberg, Erin MacKinney, Russell A. Wilke, Jennifer Gunnell, Jack Littrell, Cecilia J. Hillard, Ahmed H. Kissebah, Tesfaye M. Baye, Michael Olivier
Publikováno v:
Pharmacogenomics. 10:1929-1939
A more thorough understanding of the genetic architecture underlying obesity-related lipid disorders could someday facilitate cardiometabolic risk reduction through early clinical intervention based upon improved characterization of individual risk.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e661c8d9fea3ace9dd2d85afdd8465
https://doi.org/10.2217/pgs.09.122
https://doi.org/10.2217/pgs.09.122
Publikováno v:
The British Journal of Diabetes & Vascular Disease. 7:111-117
Obesity has reached epidemic proportions with an estimated 1.7 billion people worldwide classified as either overweight or obese. Obesity is associated with multiple co-morbidities (often clustered as the metabolic syndrome), and can result in decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef8c07983663f8ce1a815acf12afbfd
https://doi.org/10.1177/14746514070070030301
https://doi.org/10.1177/14746514070070030301