Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gabriele Cerutti"'
Autor:
Pengfei Wang, Ryan G. Casner, Manoj S. Nair, Jian Yu, Yicheng Guo, Maple Wang, Jasper F.-W. Chan, Gabriele Cerutti, Sho Iketani, Lihong Liu, Zizhang Sheng, Zhiwei Chen, Kwok-Yung Yuen, Peter D. Kwong, Yaoxing Huang, Lawrence Shapiro, David D. Ho
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 147-157 (2022)
The repeated emergence of highly pathogenic human coronaviruses as well as their evolving variants highlight the need to develop potent and broad-spectrum antiviral therapeutics and vaccines. By screening monoclonal antibodies (mAbs) isolated from CO
Externí odkaz:
https://doaj.org/article/bd6b1f73dd464708ab57777f7213a125
Autor:
Gabriele Cerutti, Elena Gugole, Linda Celeste Montemiglio, Annick Turbé-Doan, Dehbia Chena, David Navarro, Anne Lomascolo, François Piumi, Cécile Exertier, Ida Freda, Beatrice Vallone, Eric Record, Carmelinda Savino, Giuliano Sciara
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Background Fungal glucose dehydrogenases (GDHs) are FAD-dependent enzymes belonging to the glucose-methanol-choline oxidoreductase superfamily. These enzymes are classified in the “Auxiliary Activity” family 3 (AA3) of the Carbohydrate-A
Externí odkaz:
https://doaj.org/article/a1f067b794c9420f9b981cab4f6f8594
Autor:
Gabriele Cerutti, Yicheng Guo, Pengfei Wang, Manoj S. Nair, Maple Wang, Yaoxing Huang, Jian Yu, Lihong Liu, Phinikoula S. Katsamba, Fabiana Bahna, Eswar R. Reddem, Peter D. Kwong, David D. Ho, Zizhang Sheng, Lawrence Shapiro
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109928- (2021)
Summary: Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing NTD-directed antibodies have been studied structurally, and all target a single antig
Externí odkaz:
https://doaj.org/article/119804b01c4646e6825cbbdee4f5658b
Autor:
Bailey B. Banach, Gabriele Cerutti, Ahmed S. Fahad, Chen-Hsiang Shen, Matheus Oliveira De Souza, Phinikoula S. Katsamba, Yaroslav Tsybovsky, Pengfei Wang, Manoj S. Nair, Yaoxing Huang, Irene M. Francino-Urdániz, Paul J. Steiner, Matías Gutiérrez-González, Lihong Liu, Sheila N. López Acevedo, Alexandra F. Nazzari, Jacy R. Wolfe, Yang Luo, Adam S. Olia, I-Ting Teng, Jian Yu, Tongqing Zhou, Eswar R. Reddem, Jude Bimela, Xiaoli Pan, Bharat Madan, Amy D. Laflin, Rajani Nimrania, Kwok-Yung Yuen, Timothy A. Whitehead, David D. Ho, Peter D. Kwong, Lawrence Shapiro, Brandon J. DeKosky
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109771- (2021)
Summary: Understanding mechanisms of protective antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We report a monoclonal antibody, 910-30, targeting the SARS-CoV-2 receptor-binding site for ACE2 as a member of a p
Externí odkaz:
https://doaj.org/article/eeb91ec1080042a7abf186e7a830013e
Autor:
Micah Rapp, Yicheng Guo, Eswar R. Reddem, Jian Yu, Lihong Liu, Pengfei Wang, Gabriele Cerutti, Phinikoula Katsamba, Jude S. Bimela, Fabiana A. Bahna, Seetha M. Mannepalli, Baoshan Zhang, Peter D. Kwong, Yaoxing Huang, David D. Ho, Lawrence Shapiro, Zizhang Sheng
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108950- (2021)
Summary: Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies yet identified. To provide insight into whether these geneti
Externí odkaz:
https://doaj.org/article/3a5457a2eb02476c94c3b855ab19a749
Autor:
Linda Celeste Montemiglio, Elena Gugole, Ida Freda, Cécile Exertier, Lucia D’Auria, Cheng Giuseppe Chen, Alessandro Nicola Nardi, Gabriele Cerutti, Giacomo Parisi, Marco D’Abramo, Carmelinda Savino, Beatrice Vallone
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 55 (2021)
Substrate binding to the cytochrome P450 OleP is coupled to a large open-to-closed transition that remodels the active site, minimizing its exposure to the external solvent. When the aglycone substrate binds, a small empty cavity is formed between th
Externí odkaz:
https://doaj.org/article/014bc032eab746b1a328dd4a15cdb350
Autor:
Giacomo Parisi, Ida Freda, Cécile Exertier, Cristina Cecchetti, Elena Gugole, Gabriele Cerutti, Lucia D’Auria, Alberto Macone, Beatrice Vallone, Carmelinda Savino, Linda Celeste Montemiglio
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1411 (2020)
The cytochrome P450 OleP catalyzes the epoxidation of aliphatic carbons on both the aglycone 8.8a-deoxyoleandolide (DEO) and the monoglycosylated L-olivosyl-8.8a-deoxyoleandolide (L-O-DEO) intermediates of oleandomycin biosynthesis. We investigated t
Externí odkaz:
https://doaj.org/article/41af8a0b5e574c6e803d9e5b65ebcf7a
Autor:
Cécile Exertier, Federico Sebastiani, Ida Freda, Elena Gugole, Gabriele Cerutti, Giacomo Parisi, Linda Celeste Montemiglio, Maurizio Becucci, Cristiano Viappiani, Stefano Bruno, Carmelinda Savino, Carlotta Zamparelli, Massimiliano Anselmi, Stefania Abbruzzetti, Giulietta Smulevich, Beatrice Vallone
Publikováno v:
ACS Chemical Biology. 17:2099-2108
We produced a neuroglobin variant, namely, Ngb CDless, with the excised CDloop- and D-helix, directly joining the C- and E-helices. The CDless variant retained bis-His hexacoordination, and we investigated the role of the CDloop-D-helix unit in contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e9bb9ed4f95b01d43f4acb3e034be2
https://doi.org/10.1021/acschembio.2c00172
https://doi.org/10.1021/acschembio.2c00172
Autor:
Andrew Beenken, Gabriele Cerutti, Julia Brasch, Yicheng Guo, Zizhang Sheng, Hediye Erdjument-Bromage, Zainab Aziz, Shelief Y. Robbins-Juarez, Estefania Y. Chavez, Goran Ahlsen, Phinikoula S. Katsamba, Thomas A. Neubert, Anthony W.P. Fitzpatrick, Jonathan Barasch, Lawrence Shapiro
Publikováno v:
Cell
The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is representative of the phylogenetically conserved subfamily of giant LDL receptor-related proteins, which function in endocytosis and are implicated in diseases of the k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc3693d79b59ed1bad8543120d70b21
https://europepmc.org/articles/PMC9993842/
https://europepmc.org/articles/PMC9993842/
Autor:
Lihong Liu, Sho Iketani, Yicheng Guo, Eswar R. Reddem, Ryan G. Casner, Manoj S. Nair, Jian Yu, Jasper F.-W. Chan, Maple Wang, Gabriele Cerutti, Zhiteng Li, Nicholas C. Morano, Candace D. Castagna, Laura Corredor, Hin Chu, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chun-Sing Chan, Zhiwei Chen, Yang Luo, Marcus Cunningham, Alejandro Chavez, Michael T. Yin, David S. Perlin, Moriya Tsuji, Kwok-Yung Yuen, Peter D. Kwong, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro, David D. Ho
Publikováno v:
Science translational medicine. 14(646)
The devastation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in the sarbecovirus subgenus, we identified a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814f2a3609eb930beee05c6bd87c2bb3
https://pubmed.ncbi.nlm.nih.gov/35438546
https://pubmed.ncbi.nlm.nih.gov/35438546