Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Gabriele Baj"'
Autor:
Sébastien Delhaye, Marielle Jarjat, Asma Boulksibat, Clara Sanchez, Alessandra Tempio, Andrei Turtoi, Mauro Giorgi, Sandra Lacas-Gervais, Gabriele Baj, Carole Rovere, Viviana Trezza, Manuela Pellegrini, Thomas Maurin, Enzo Lalli, Barbara Bardoni
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106393- (2024)
Phosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is u
Externí odkaz:
https://doaj.org/article/c714b13b016449ffbe190912a5d2ec29
Autor:
Marianna Maddaloni, Rossella Farra, Barbara Dapas, Fulvia Felluga, Fabio Benedetti, Federico Berti, Sara Drioli, Mattia Vidali, Maja Cemazar, Urska Kamensek, Claudio Brancolini, Erminio Murano, Francesca Maremonti, Mario Grassi, Alice Biasin, Flavio Rizzolio, Enrico Cavarzerani, Bruna Scaggiante, Roberta Bulla, Andrea Balduit, Giuseppe Ricci, Gabriella Zito, Federico Romano, Serena Bonin, Eros Azzalini, Gabriele Baj, Domenico Tierno, Gabriele Grassi
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 664 (2024)
Background: The identification of novel therapeutic strategies for ovarian cancer (OC), the most lethal gynecological neoplasm, is of utmost urgency. Here, we have tested the effectiveness of the compound 2c (4-hydroxy-2,6-bis(4-nitrobenzylidene)cycl
Externí odkaz:
https://doaj.org/article/9cda9d91d298443aa1fd39a5f208d7da
Autor:
Mattia Apollonio, Arianna Bellazzo, Nicoletta Franco, Silvia Lombardi, Beatrice Senigagliesi, Loredana Casalis, Pietro Parisse, Agnes Thalhammer, Gabriele Baj, Rossella De Florian Fania, Giannino Del Sal, Licio Collavin
Publikováno v:
Cancers, Vol 15, Iss 13, p 3379 (2023)
External and internal mechanical forces modulate cell morphology, movement, proliferation and metabolism, and represent crucial inputs for tissue homeostasis. The transcriptional regulators YAP and TAZ are important effectors of mechanical signaling
Externí odkaz:
https://doaj.org/article/a0510b78d4c04e69abbd0180efb58e09
Autor:
Giulia Bortolussi, Xiaoxia Shi, Lysbeth ten Bloemendaal, Bhaswati Banerjee, Dirk R. De Waart, Gabriele Baj, Weiyu Chen, Ronald P. Oude Elferink, Ulrich Beuers, Coen C. Paulusma, Roland Stocker, Andrés F. Muro, Piter J. Bosma
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 2029 (2021)
Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause irreversible brain damage and death. Strategies to inhibit bilirubin production and prevent neurotoxic
Externí odkaz:
https://doaj.org/article/9e009047432a43d0942b9885748f455b
Autor:
Alessio Polacchini, Clara Albani, Gabriele Baj, Andrea Colliva, Patrizia Carpinelli, Enrico Tongiorgi
Publikováno v:
Biology Open, Vol 5, Iss 7, Pp 899-907 (2016)
Drug-resistance to chemotherapics in aggressive neuroblastoma (NB) is characterized by enhanced cell survival mediated by TrkB and its ligand, brain-derived neurotrophic factor (BDNF); thus reduction in BDNF levels represent a promising strategy to o
Externí odkaz:
https://doaj.org/article/c4a54c6ce7a24e619747f4c93e619788
Autor:
Giulia Chiaruttini, Giulia M. Piperno, Mabel Jouve, Francesca De Nardi, Paola Larghi, Andrew A. Peden, Gabriele Baj, Sabina Müller, Salvatore Valitutti, Thierry Galli, Federica Benvenuti
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2624-2636 (2016)
Interleukin-12 (IL-12), produced by dendritic cells in response to activation, is central to pathogen eradication and tumor rejection. The trafficking pathways controlling spatial distribution and intracellular transport of IL-12 vesicles to the cell
Externí odkaz:
https://doaj.org/article/114c0cc38a9040f1b2dfd9d4f659ad7c
Autor:
Wibke Singer, Marie Manthey, Rama Panford-Walsh, Lucas Matt, Hyun-Soon Geisler, Eleonora Passeri, Gabriele Baj, Enrico Tongiorgi, Graciano Leal, Carlos B. Duarte, Ivan L. Salazar, Philipp Eckert, Karin Rohbock, Jing Hu, Jörg Strotmann, Peter Ruth, Ulrike Zimmermann, Lukas Rüttiger, Thomas Ott, Thomas Schimmang, Marlies Knipper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Bdnf exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. However, how their differential transcription translates activity changes into long-lasting network chang
Externí odkaz:
https://doaj.org/article/3cb0c2e2e5294877a4c2b7fa0e4a4b48
Autor:
Paolo Durigutto, Daniele Sblattero, Stefania Biffi, Luca De Maso, Chiara Garrovo, Gabriele Baj, Federico Colombo, Fabio Fischetti, Antonio F. Di Naro, Francesco Tedesco, Paolo Macor
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage. A problem that still needs to be solved in the therapeutic c
Externí odkaz:
https://doaj.org/article/97ab0481344745119af4128c212913b0
Autor:
Giulia Bortolussi, Gabriele Baj, Simone Vodret, Giulia Viviani, Tamara Bittolo, Andrés F. Muro
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 9, Pp 1057-1068 (2014)
Neonatal jaundice is caused by high levels of unconjugated bilirubin. It is usually a temporary condition caused by delayed induction of UGT1A1, which conjugates bilirubin in the liver. To reduce bilirubin levels, affected babies are exposed to photo
Externí odkaz:
https://doaj.org/article/4c806af9109543f6a24e6b8785c25d8d
Autor:
Davide Carlino, Ruggiero Francavilla, Gabriele Baj, Karolina Kulak, Pio d’Adamo, Sheila Ulivi, Stefania Cappellani, Paolo Gasparini, Enrico Tongiorgi
Publikováno v:
PeerJ, Vol 3, p e1252 (2015)
Anxiety disorders (ADs) are disabling chronic disorders with exaggerated behavioral response to threats. This study was aimed at testing the hypothesis that ADs may be associated with reduced neurotrophic activity, particularly of Brain-derived neuro
Externí odkaz:
https://doaj.org/article/1307fa9001734a37815bff5a9b00de58