Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Gabriele, Pollara"'
Autor:
Ffion R Hammond, Amy Lewis, Gabriele Pollara, Gillian S Tomlinson, Mahdad Noursadeghi, Endre Kiss-Toth, Philip M Elks
Publikováno v:
eLife, Vol 13 (2024)
Tuberculosis is a major global health problem and is one of the top 10 causes of death worldwide. There is a pressing need for new treatments that circumvent emerging antibiotic resistance. Mycobacterium tuberculosis parasitises macrophages, reprogra
Externí odkaz:
https://doaj.org/article/bd3dd043b8a54eb0866c183d509594af
Autor:
Carolin T. Turner, James Brown, Emily Shaw, Imran Uddin, Evdokia Tsaliki, Jennifer K. Roe, Gabriele Pollara, Yuxin Sun, James M. Heather, Marc Lipman, Benny Chain, Mahdad Noursadeghi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent
Externí odkaz:
https://doaj.org/article/0498c9ebe0f942879a3f5aaafba9661a
Autor:
Lucy C.K. Bell, Cem Meydan, Jacob Kim, Jonathan Foox, Daniel Butler, Christopher E. Mason, Sagi D. Shapira, Mahdad Noursadeghi, Gabriele Pollara
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101896- (2021)
Summary: Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines in vivo are urgently needed to com
Externí odkaz:
https://doaj.org/article/8ebe48f1fdef4850846e6654ad7d6bc1
Autor:
André N. A. Gonçalves, Melissa Lever, Pedro S. T. Russo, Bruno Gomes-Correia, Alysson H. Urbanski, Gabriele Pollara, Mahdad Noursadeghi, Vinicius Maracaja-Coutinho, Helder I. Nakaya
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Transcriptome analyses have increased our understanding of the molecular mechanisms underlying human diseases. Most approaches aim to identify significant genes by comparing their expression values between healthy subjects and a group of patients wit
Externí odkaz:
https://doaj.org/article/a1aeaa364c774bee95cc4aebf392b5d8
Autor:
Maphe Mthembu, Helgard Claassen, Sharon Khuzwayo, Valentin Voillet, Anneta Naidoo, Kennedy Nyamande, Dilshaad F. Khan, Priya Maharaj, Mohammed Mitha, Zoey Mhlane, Farina Karim, Erica Andersen-Nissen, Thumbi Ndung’u, Gabriele Pollara, Emily B. Wong
Publikováno v:
bioRxiv
Mechanisms by which HIV causes susceptibility to respiratory pathogens remain incompletely understood. We obtained whole blood and bronchoalveolar lavage (BAL) from people with latent TB infection in the presence or absence of antiretroviral-naïve H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c43a1f55bd116de30d9d4f922ff0a33
https://doi.org/10.1101/2023.05.05.539571
https://doi.org/10.1101/2023.05.05.539571
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0223130 (2019)
BackgroundThe incidence of multi-drug resistant ESBL-associated urinary tract infections (UTIs) is increasing globally. Patients with abnormal renal tract anatomy and other co-morbidities are at increased risk of complicated UTI and ESBL-associated i
Externí odkaz:
https://doaj.org/article/00bb588b8fd041279f81b473dfba57ff
Autor:
Rita Patrocínio de Jesus, Hamish Houston, Annemiek H J Schutte, Stephen Morris-Jones, Neil Stone, Rebecca Gorton, Gabriele Pollara
Publikováno v:
JAC-Antimicrobial Resistance. 5
Objectives To assess the performance of T2Candida for the diagnosis of invasive candidiasis (IC) against gold standards of candidaemia or consensus IC definitions, and to evaluate the impact of T2Candida on antifungal drug prescribing. Methods A retr
Autor:
Rachel Byng-Maddick, Carolin T. Turner, Gabriele Pollara, Matthew Ellis, Naomi J. Guppy, Lucy C. K. Bell, Michael R. Ehrenstein, Mahdad Noursadeghi
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The impact of anti-tumor necrosis factor (TNF) therapies on inducible TNF-dependent activity in humans has never been evaluated in vivo. We aimed to test the hypothesis that patients responding to anti-TNF treatments exhibit attenuated TNF-dependent
Externí odkaz:
https://doaj.org/article/c22d2d58da354ddfbab38abe151315d1
Autor:
Gabriele Pollara, Matthew J Murray, James M Heather, Rachel Byng-Maddick, Naomi Guppy, Matthew Ellis, Carolin T Turner, Benjamin M Chain, Mahdad Noursadeghi
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169271 (2017)
Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However, significant diversity in module gene content for specific cell types is associated with heter
Externí odkaz:
https://doaj.org/article/b6d96bebc5964668a31d80fb86bad66f
Autor:
Tanmay Kanitkar, Emmanuel Q Wey, Marisa Lanzman, Gabriele Pollara, Claire Y Mason, Charlotte J Richardson, Damien Mack, Zak Stone, Tabitha Mahungu, Lucy Lamb, Indran Balakrishnan
Publikováno v:
Journal of Antimicrobial Chemotherapy
Background COVID-19 is infrequently complicated by bacterial co-infection, but antibiotic prescriptions are common. We used community-acquired pneumonia (CAP) as a benchmark to define the processes that occur in bacterial pulmonary infections, testin