Výsledky vyhledávání - "Gabriele, Picco"

Akademický článek

Collaborative artificial intelligence system for investigation of healthcare claims compliance

Autor: Marco Luca Sbodio, Vanessa López, Thanh Lam Hoang, Theodora Brisimi, Gabriele Picco, Inge Vejsbjerg, Valentina Rho, Pol Mac Aonghusa, Morten Kristiansen, John Segrave-Daly

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

Abstract Healthcare fraud, waste and abuse are costly problems that have huge impact on society. Traditional approaches to identify non-compliant claims rely on auditing strategies requiring trained professionals, or on machine learning methods requi

Externí odkaz: https://doaj.org/article/c5a6bd22d8f64f2f8c06aa02dbcd0a9e

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Akademický článek

Minimal genome-wide human CRISPR-Cas9 library

Autor: Emanuel Gonçalves, Mark Thomas, Fiona M. Behan, Gabriele Picco, Clare Pacini, Felicity Allen, Alessandro Vinceti, Mamta Sharma, David A. Jackson, Stacey Price, Charlotte M. Beaver, Oliver Dovey, David Parry-Smith, Francesco Iorio, Leopold Parts, Kosuke Yusa, Mathew J. Garnett

Publikováno v: Genome Biology, Vol 22, Iss 1, Pp 1-14 (2021)

Abstract CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibC

Externí odkaz: https://doaj.org/article/2fa4d024f7b14d10b1fef8e9f3b2d270

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Akademický článek

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage betw

Externí odkaz: https://doaj.org/article/faee146ac94c4c129948d57be9f339e0

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Akademický článek

Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens

Publikováno v: Molecular Systems Biology, Vol 16, Iss 7, Pp n/a-n/a (2020)

Abstract Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated 199,219 drug sensitivity measurements for 397 unique an

Externí odkaz: https://doaj.org/article/8d3c7a8706894b218dbc302dbd8ec445

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Akademický článek

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

Autor: Gabriele Picco, Consalvo Petti, Alessia Centonze, Erica Torchiaro, Giovanni Crisafulli, Luca Novara, Andrea Acquaviva, Alberto Bardelli, Enzo Medico

Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 3, Pp 293-303 (2017)

Abstract In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However, its low prevalence severely limits availability of preclinical models for in‐depth characterization. Using a

Externí odkaz: https://doaj.org/article/a44c8d397cc74b11b8277afa65862329

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