Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Gabriele, Blahnik"'
2
Akademický článek
Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining
Autor: Hannes Uchtenhagen, Cliff Rims, Gabriele Blahnik, I-Ting Chow, William W. Kwok, Jane H. Buckner, Eddie A. James
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Detection of antigen specificity in a blood sample is limited by low frequencies of individual clones. Here the authors develop an MHC class II combinatorial technique and apply it to immunophenotype human CD4+ T cells of multiple specificities in re
Externí odkaz: https://doaj.org/article/a2822371a2184c1581f604ee30e21895
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4
T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope
Autor: Yi Jing, Yuelin Kong, John McGinty, Gabriele Blahnik-Fagan, Thomas Lee, Stephanie Orozco-Figueroa, Matthew L. Bettini, Eddie A. James, Maria Bettini
Publikováno v: Diabetes
Accumulating evidence supports a critical role for posttranslationally modified (PTM) islet neoantigens in type 1 diabetes. However, our understanding regarding thymic development and peripheral activation of PTM autoantigen-reactive T cells is still
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c68aa161acac283ee26bf9bf2c7716
https://europepmc.org/articles/PMC9044133/
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5
TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Post-translationally Modified GAD65 Epitope
Autor: Maria Bettini, Eddie A. James, Matthew L. Bettini, Stephanie Orozco-Figueroa, Thomas Lee, Gabriele Blahnik-Fagan, John McGinty, Yuelin Kong, Yi Jing
Accumulating evidence supports a critical role for post-translationally modified (PTM) islet neoantigens in type 1 diabetes. However, our understanding regarding thymic development and peripheral activation of PTM autoantigen reactive T cells is stil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47492370ae5194c1235f210a9e7b3a40
https://doi.org/10.2337/figshare.19184456
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6
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
Autor: Gabriele Blahnik, Elisavet Serti, Matthew J. Dufort, Cate Speake, Peter S. Linsley, Hannah A. DeBerg, Anna Kus, Eddie A. James, Bertrand Haas, Scott R. Presnell, Virginia S. Muir, Gerald T. Nepom, Mario G. Rosasco, S. Alice Long, Alice E. Wiedeman, Carla J. Greenbaum
Publikováno v: Journal of Clinical Investigation. 130:480-490
Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell loss varies across individuals. It is not clear what drives this differential progression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e0805be8c643ff061e0c39d2cf54cef
https://doi.org/10.1172/jci126595
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7
Akademický článek
A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes.
Autor: Mehul S Suthar, Margaret M Brassil, Gabriele Blahnik, Aimee McMillan, Hilario J Ramos, Sean C Proll, Sarah E Belisle, Michael G Katze, Michael Gale
Publikováno v: PLoS Pathogens, Vol 9, Iss 2, p e1003168 (2013)
The actions of the RIG-I like receptor (RLR) and type I interferon (IFN) signaling pathways are essential for a protective innate immune response against the emerging flavivirus West Nile virus (WNV). In mice lacking RLR or IFN signaling pathways, WN
Externí odkaz: https://doaj.org/article/85948703cf5344418ca759d793a6098e
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9
287-OR: TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope
Autor: John W. McGinty, Eddie A. James, Yi Jing, Matthew L. Bettini, Maria Bettini, Gabriele Blahnik-Fagan, Yuelin Kong
Publikováno v: Diabetes. 69
T cells specific for post-translationally modified (PTM) islet antigens have been implicated as critical players in the development of type 1 diabetes. T cells reactive to the deamidated version of glutamic acid decarboxylase 65 (GAD65) 115-127 epito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db0983d6c7f5cd523fdf1fc4547a8e1c
https://doi.org/10.2337/db20-287-or
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10
Akademický článek
IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection.
Autor: Hilario J Ramos, Marion C Lanteri, Gabriele Blahnik, Amina Negash, Mehul S Suthar, Margaret M Brassil, Khushbu Sodhi, Piper M Treuting, Michael P Busch, Philip J Norris, Michael Gale
Publikováno v: PLoS Pathogens, Vol 8, Iss 11, p e1003039 (2012)
West Nile virus (WNV) is an emerging flavivirus capable of infecting the central nervous system (CNS) and mediating neuronal cell death and tissue destruction. The processes that promote inflammation and encephalitis within the CNS are important for
Externí odkaz: https://doaj.org/article/62ea5d3543ed495dad05b14cda188cc0
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