Výsledky vyhledávání - "Gabriela de los Santos"

Akademický článek

2001 α-ketoglutarate-dependent KDM6 histone demethylases epigenetically regulate Interferon Stimulated Gene expression in Lupus

Autor: Janet Wei, C Noel Bairey Merz, Daniel J Wallace, Sarah Parker, Mariko Ishimori, Caroline Jefferies, Erica N Montano, Moumita Bose, Lihong Huo, Gantsetseg Tumurkhuu, Gabriela De Los Santos, Aleksandr B Stotland, Gislaine Martins, Sarfaraz Lalani, Kate Lawrenson

Publikováno v: Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)

Externí odkaz: https://doaj.org/article/c20bea34e6af4aa0947391ac486ba130

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Akademický článek

Neutrophils Contribute to ER Stress in Lung Epithelial Cells in the Pristane-Induced Diffuse Alveolar Hemorrhage Mouse Model

Autor: Gantsetseg Tumurkhuu, Duygu Ercan Laguna, Richard E. Moore, Jorge Contreras, Gabriela De Los Santos, Luisa Akaveka, Erica N. Montano, Yizhou Wang, Mariko Ishimori, Swamy Venuturupalli, Lindsy J. Forbess, Barry R. Stripp, Daniel J. Wallace, Caroline A. Jefferies

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Diffuse alveolar hemorrhage (DAH), although rare, is a life-threatening complication of systemic lupus erythematosus (SLE). Little is known about the pathophysiology of DAH in humans, although increasingly neutrophils, NETosis and inflammatory monocy

Externí odkaz: https://doaj.org/article/16d6495b0a4a4ec9b252b49043fdb93d

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Akademický článek

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Autor: Gantsetseg Tumurkhuu, Shuang Chen, Erica N. Montano, Duygu Ercan Laguna, Gabriela De Los Santos, Jeong Min Yu, Malcolm Lane, Michifumi Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Timothy R. Crother, Mariko Ishimori, Daniel J. Wallace, Caroline A. Jefferies, Moshe Arditi

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repa

Externí odkaz: https://doaj.org/article/804a8420fafe4285aba0bf129953d581

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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Publikováno v: Hooftman, A, G. Peace, C, G. Ryan, D, A. Day, E, Yang, M, F. McGettrick, A, Yin, M, N. Montano, E, Huo, L, E. Toller-Kawahisa, J, Zecchini, V, A. J. Ryan, T, Bolado Carrancio, A, M. Casey, A, A. Prag, H, S.H. Costa, A, De Los Santos, G, Ishimori, M, J. Wallace, D, Venuturupalli, S, Nikitopoulou, E, Frizzell, N, Johansson, C, von Kriegsheim, A, P. Murphy, M, Jefferies, C, Frezza, C & A.J. O'Neill, L 2023, ' Macrophage fumarate hydratase restrains mtRNA-mediated interferon production ', Nature, vol. 615, pp. 490-498 . https://doi.org/10.1038/s41586-023-05720-6

Metabolic rewiring underlies the effector functions of macrophages 1–3, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory aspartate–arginin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1440c30dd8894932c61643e40d2cc0cc
http://hdl.handle.net/10044/1/104575