Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection.

Autor: Alexandra G Fraga, Gabriela Trigo, Ramya K Murthy, Shamim Akhtar, Madhavi Hebbur, Ana Rita Pacheco, Juan Dominguez, Rita Silva-Gomes, Carine M Gonçalves, Hugo Oliveira, António G Castro, Umender Sharma, Joana Azeredo, Jorge Pedrosa

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007113 (2019)

Buruli Ulcer (BU) is a cutaneous disease caused by Mycobacterium ulcerans. The pathogenesis of this disease is closely related to the secretion of the toxin mycolactone that induces extensive destruction of the skin and soft tissues. Currently, there

Externí odkaz: https://doaj.org/article/be335171665840bbb480559a2a6a4957

Phage therapy is effective against infection by Mycobacterium ulcerans in a murine footpad model.

Autor: Gabriela Trigo, Teresa G Martins, Alexandra G Fraga, Adhemar Longatto-Filho, António G Castro, Joana Azeredo, Jorge Pedrosa

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 4, p e2183 (2013)

BACKGROUND: Buruli Ulcer (BU) is a neglected, necrotizing skin disease caused by Mycobacterium ulcerans. Currently, there is no vaccine against M. ulcerans infection. Although the World Health Organization recommends a combination of rifampicin and s

Externí odkaz: https://doaj.org/article/0745db1aaee244ef89bb6b35d82718ea

Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection

Autor: Joana Azeredo, Jorge Pedrosa, Hugo Alexandre Mendes Oliveira, Umender Sharma, Rita Silva-Gomes, Madhavi Hebbur, Alexandra G. Fraga, António G. Castro, Gabriela Trigo, Carine M. Gonçalves, Juan Dominguez, Ramya K. Murthy, Shamim Akhtar, Ana Rita Pacheco

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007113 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS Neglected Tropical Diseases

Buruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Although the current antibiotic treatment for BU is effective, daily administrations for a prolonged period of time, combined with potential risk of severe side effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8b6f18a58166f5c5fd774a22ff6b8c
https://doaj.org/article/be335171665840bbb480559a2a6a4957

rEnolase Maternal Immunization Confers Caries Protection on Offspring

Autor: Márcia Dinis, Adília Ribeiro, A.J.M.M. Fonseca, António Silvério Cabrita, Paula Ferreira, Gabriela Trigo, N. Chaves, Delfina Tavares

Publikováno v: Journal of Dental Research. 90:325-330

Therapeutic vaccination with Streptococcus sobrinus recombinant enolase (rEnolase) protects rats from dental caries. Here, we investigated the effect that maternal rEnolase vaccination before pregnancy had on the offspring’s immune response to S. s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebb9d954e96efc02624928c465caa0f
https://doi.org/10.1177/0022034510391793

Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model

Autor: António G. Castro, Gabriela Trigo, Elly Marcq, Carine M. Gonçalves, Jorge Pedrosa, Rita Silva-Gomes, Alexandra G. Fraga, Adhemar Longatto-Filho

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004265 (2015)
PLoS Neglected Tropical Diseases
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Buruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans infection. BU is characterized by a wide range of clinical forms, including non-ulcerative cutaneous lesions that can evolve into severe ulcers if left untreated. Nevert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65583379095c6e15dc49081dfc359bf5
http://europepmc.org/articles/PMC4666642?pdf=render