Výsledky vyhledávání - "Gabriela S. Tam"

In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Autor: John J. Tanner, Gabriela S. Tam, Anke Vandekeere, Alexandra N. Bogner, Sagar M. Patel, Emily M. Christensen, Donald F. Becker, Sarah-Maria Fendt

Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry

Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d1f0867fe7a0a3900fc23d93d6e2a4
https://doi.org/10.1074/jbc.ra120.016106

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Bridging scales: From cell biology to physiology using in situ single-cell technologies

Autor: Evan Maltz, Roy Wollman, Maeve P. Nagle, Zachary Hemminger, Gabriela S. Tam

Publikováno v: Cell systems. 12(5)

Biological organization crosses multiple spatial scales: from molecular, cellular, to tissues and organs. The proliferation of molecular profiling technologies enables increasingly detailed cataloging of the components at each scale. However, the sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45fdc8c2df58bb18245ddce4b8d7994
https://pubmed.ncbi.nlm.nih.gov/34015260

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