Evaluation of β-glucan particles as dual-function carriers for poorly soluble drugs

Autor: Martin Balouch, Ivan Saloň, Petra Šalamúnová, Jaroslav Hanuš, František Štěpánek, Jiřina Kroupová, Gabriela Ruphuy

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 168:15-25

Yeast glucan particles are porous polysaccharide cell walls extracted from Saccharomyces cerevisiae. Being mildly immunogenic, they are efficiently phagocytosed and have therefore been proposed as possible vehicles for drug delivery. Using curcumin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3725a809cdcba479c58ca501cbc708
https://doi.org/10.1016/j.ejpb.2021.08.001

Encapsulation of poorly soluble drugs in yeast glucan particles by spray drying improves dispersion and dissolution properties

Autor: Gabriela Ruphuy, Petra Šalamúnová, František Štěpánek, Jan Tomas, Ivan Saloň, Jaroslav Hanuš

Publikováno v: International journal of pharmaceutics. 576

In this work, novel amorphous solid dispersions based on yeast glucan particles were produced. Yeast glucan particles are hollow and porous, and they are mainly composed of amorphous polysaccharides. We hypothesized that these particles are suitable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b576c926eabc7db214d12b5826f72da0
https://pubmed.ncbi.nlm.nih.gov/31899318

New insights into nanohydroxyapatite/chitosan nanocomposites for bone tissue regeneration

Autor: Maria Filomena Barreiro, Gabriela Ruphuy, José Carlos B. Lopes, Madalena M. Dias

The chapter comprises a compilation of the latest main achievements that have been published on hydroxyapatite (HAp)-based nanocomposite materials, focusing on the combination of HAp with CS. It includes fundamental definitions about HAp and CS, thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3b381eba1c23485f666a9a0eed09774
https://doi.org/10.1016/b978-0-12-816909-4.00011-7

Supercritical CO2 assisted process for the production of high-purity and sterile nano-hydroxyapatite/chitosan hybrid scaffolds

Autor: José Carlos B. Lopes, Gabriela Ruphuy, Maria Helena Fernandes, Alírio E. Rodrigues, Madalena M. Dias, Diana Paiva, Fernando J. Monteiro, M.F. Barreiro, Christiane L. Salgado, M. Souto‐Lopes, Patrícia Costa

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Hybrid scaffolds composed of hydroxyapatite (HAp), in particular in its nanometric form (n-HAp), and chitosan (CS) are promising materials for non-load-bearing bone graft applications. The main constraints of their production concern the successful i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb6398d8be846ca35c2418772fc9267

A bioactive formulation based on Fragaria vesca L. vegetative parts: Chemical characterisation and application in κ-carrageenan gelatin

Autor: Lillian Barros, Gabriela Ruphuy, M. Beatriz P.P. Oliveira, Celestino Santos-Buelga, Maria Inês Dias, Maria Filomena Barreiro, Isabel C.F.R. Ferreira, Isabel Fernandes

Publikováno v: Journal of Functional Foods, Vol 16, Iss, Pp 243-255 (2015)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

A bioactive formulation based on the vegetative parts of the wild strawberry, Fragaria vesca L., was developed by using a microencapsulated extract (lyophilized infusion form). For that purpose, a process based on an atomization/coagulation technique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fbb1078438a2fdad7ae8f94e7b7cba
http://www.sciencedirect.com/science/article/pii/S1756464615002170