Výsledky vyhledávání - "Gabriela Mazzocchi"

Rol de la CaMKII en las arritmias por isquemia/reperfusión y estrés: estudio del papel de la recaptura del Ca2+ intracelular

Autor: Gabriela Mazzocchi

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

La disfunción mecánica y las arritmias son dos hechos característicos de la insuficiencia cardíaca (IC), una causa principal de morbimortalidad a nivel mundial (Cleland y col., 2002; Mozaffarian y col., 2007; Benjamin y col.,2017). Actualmente se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1552fb07aadd572772001312d603bd
https://doi.org/10.35537/10915/64760

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Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814

Autor: Julieta Palomeque, Gabriela Mazzocchi, Evangelia G. Kranias, Alicia Mattiazzi, D. Fainstein, Darlene G. Skapura, Xander H.T. Wehrens, Mark McCauley, P. N. González, Leandro Matías Sommese, Jorge A. Negroni, P. Contreras, M. N. Di Carlo, Juan Ignacio Felice, Elena C. Lascano, Carlos Alfredo Valverde

Publikováno v: The Journal of Physiology. 594:3005-3030

Key points Mice with Ca(2+) -calmodulin-dependent protein kinase (CaMKII) constitutive pseudo-phosphorylation of the ryanodine receptor RyR2 at Ser2814 (S2814D(+/+) mice) exhibit a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::746763441678051258a337b9ff0be179
https://doi.org/10.1113/jp271622

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Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors

Autor: Juan Ignacio Felice, Mariano N Di Carlo, Enrique Leo Portiansky, Alejandra Cely-Ortiz, Carlos Alfredo Valverde, Alicia Elvira Consolini, Evangelia G. Kranias, Gabriela Mazzocchi, Alicia Mattiazzi, Xander H.T. Wehrens, Nehuen Salas, Susana M. Mosca, María Inés Ragone, Alejandro Ciocci Pardo

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Aims Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb312af627bc1a43478e0f41e25969aa
http://sedici.unlp.edu.ar/handle/10915/124352

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Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity

Autor: Evaristo Fernández-Sada, S. L. Rivero, Yuriana Oropeza-Almazán, B. C. Willis, Christian Silva-Platas, César A. Villegas, Noemí García, Gabriela Mazzocchi, Guillermo Torre-Amione, Gerardo García-Rivas, Carlos Alfredo Valverde, Cecilia Zazueta, J. R. Garza

Publikováno v: British Journal of Pharmacology. 171:4207-4221

Background and Purpose Despite the importance of mitochondrial Ca2+ to metabolic regulation and cell physiology, little is known about the mechanisms that regulate Ca2+ entry into the mitochondria. Accordingly, we established a system to determine th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77cddca027a308805200feee40a8b7c5
https://doi.org/10.1111/bph.12684

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Ca2+ Sparks and Ca2+ waves are the subcellular events underlying Ca2+ overload during ischemia and reperfusion in perfused intact hearts

Autor: Yuriana Aguilar-Sanchez, Mariana Argenziano, Ariel L. Escobar, Gabriela Mazzocchi, Alicia Mattiazzi

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Abnormal intracellular Ca2+ cycling plays a key role in cardiac dysfunction, particularly during the setting of ischemia/reperfusion (I/R). During ischemia, there is an increase in cytosolic and sarcoplasmic reticulum (SR) Ca2+. At the onset of reper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012e4e3d69a150cc99c5d12c8ba1f549
https://escholarship.org/uc/item/24g233n1

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