Clinical Trials Using Mesenchymal Stem Cells for Spinal Cord Injury: Challenges in Generating Evidence

Autor: Lila Teixeira de Araújo, Carolina Thé Macêdo, Patrícia Kauanna Fonseca Damasceno, Ítalo Gabriel Costa das Neves, Carla Souza de Lima, Girlaine Café Santos, Thaís Alves de Santana, Gabriela Louise de Almeida Sampaio, Daniela Nascimento Silva, Cristiane Flora Villarreal, Alessandra Casemiro de Campos Chaguri, Crislaine Gomes da Silva, Augusto César de Andrade Mota, Roberto Badaró, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares

Publikováno v: Cells, Vol 11, Iss 6, p 1019 (2022)

Spinal cord injury (SCI) remains an important public health problem which often causes permanent loss of muscle strength, sensation, and function below the site of the injury, generating physical, psychological, and social impacts throughout the live

Externí odkaz: https://doaj.org/article/fbe6c51bc9d7450bba281fa96d7f2146

Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency

Autor: Gabriela Louise de Almeida Sampaio, Gabriele Louise Soares Martins, Bruno Diaz Paredes, Carolina Kymie Vasques Nonaka, Katia Nunes da Silva, Erik Aranha Rossi, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Bruno Solano de Freitas Souza

Publikováno v: Stem Cell Research, Vol 39, Iss , Pp - (2019)

Autism spectrum disorders (ASDs) are a group of diseases that affect social interaction, communication and behavior. Molecular mechanisms involved in the pathogenesis of ASDs are complex due to genetic heterogeneity. Recently, pathogenic variants of

Externí odkaz: https://doaj.org/article/0eeb811d30e74c19a9d396906759192b

Therapeutic mir-21 silencing reduces cardiac fibrosis and modulates inflammatory response in chronic chagas disease

Autor: Bruno Diaz Paredes, Luciana Souza de Aragão França, Emanuelle de Souza Santos, Gabriela Louise de Almeida Sampaio, Bruno Raphael Ribeiro Cavalcante, Vinícius Pinto Costa Rocha, Ricardo Khouri, Silvia Regina Rogatto, Milena Botelho Pereira Soares, Ricardo Ribeiro dos Santos, Cássio Santana Meira, Kátia Nunes da Silva, Bruno Solano de Freitas Souza, Carolina Kymie Vasques Nonaka, Felipe Guimarães Torres

Publikováno v: Nonaka, C K V, Sampaio, G L, França, L D A, Cavalcante, B R R, Silva, K N, Khouri, R, Torres, F G, Meira, C S, Santos, E D S, Macedo, C T, Paredes, B D, Rocha, V P C, Rogatto, S R, Santos, R R D, Souza, B S D F & Soares, M B P 2021, ' Therapeutic mir-21 silencing reduces cardiac fibrosis and modulates inflammatory response in chronic chagas disease ', International Journal of Molecular Sciences, vol. 22, no. 7, 3307 . https://doi.org/10.3390/ijms22073307
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3307, p 3307 (2021)

Chagas disease, caused by the parasite Trypanosoma cruzi (T. cruzi), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense cardiac fibrosis and inflammation are hallmarks of chronic Chagas dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd391792863777e10febbccff808824
https://findresearcher.sdu.dk:8443/ws/files/181181337/Open_Access_Version.pdf

Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells

Autor: Daniela Nascimento Silva, Iasmim Diniz Orge, Brysa Mariana Dias Silveira, Ricardo Ribeiro-dos-Santos, Milena Botelho Pereira Soares, Bruno Diaz Paredes, Thaís Alves de Santana, Vitor Fortuna, Gabriela Louise de Almeida Sampaio, Girlaine Café Santos

Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Mesenchymal stem/stromal cells (MSCs) have the ability to secrete bioactive molecules, exerting multiple biological effects, such as tissue regeneration, reduction of inflammation, and neovascularization. The therapeutic potential of MSCs can be incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35ca67936fba2b0baada02f6afe8ac4

Generation of integration-free iPS cell lines from three sickle cell disease patients from the state of Bahia, Brazil

Autor: C. S. Pereira, Carine Machado Azevedo, Bruno Diaz Paredes, Milena Botelho Pereira Soares, Carolina Kymie Vasques Nonaka, Gabriele Louise Soares Martins, Ricardo Ribeiro dos Santos, Kátia Nunes da Silva, Bruno Solano de Freitas Souza, Gabriela Louise de Almeida Sampaio, Bruno Raphael Ribeiro Cavalcante

Publikováno v: Stem Cell Research, Vol 33, Iss, Pp 10-14 (2018)

Sickle cell disease (SCD) is one of the most prevalent and severe monogenetic disorders, affecting several million people around the world. Clinical manifestations and complications of the disease include sickle cell pain crisis, silent cerebral infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3a7eafc13aeee745d105df7b426323
https://pubmed.ncbi.nlm.nih.gov/30296668