Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gabriela Krivdova"'
Autor:
Gabriela Krivdova, Veronique Voisin, Erwin M. Schoof, Sajid A. Marhon, Alex Murison, Jessica L. McLeod, Martino M. Gabra, Andy G.X. Zeng, Stefan Aigner, Brian A. Yee, Alexander A. Shishkin, Eric L. Van Nostrand, Karin G. Hermans, Aaron C. Trotman-Grant, Nathan Mbong, James A. Kennedy, Olga I. Gan, Elvin Wagenblast, Daniel D. De Carvalho, Leonardo Salmena, Mark D. Minden, Gary D. Bader, Gene W. Yeo, John E. Dick, Eric R. Lechman
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110481- (2022)
Summary: Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells (HSCs) point to shared core stemness properties. However, discordance between mRNA and protein signatures highlights an important role for post-
Externí odkaz:
https://doaj.org/article/939447993067409d9b5458011e74bcb6
Autor:
Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I. Gan, John E. Dick, Eric R. Lechman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Previous gene editing in haematopoietic stem cells (HSCs) has focussed on a heterogeneous CD34+ population. Here, the authors demonstrate high efficiency CRISPR/Cas9-based editing of purified long-term HSCs using non-homologous end joining and homolo
Externí odkaz:
https://doaj.org/article/0b4499f298ce4f27a378fb08edca0925
Autor:
Ava Keyvani Chahi, Muluken S. Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Veronique Voisin, Gabriela Krivdova, Eric Lechman, Sajid A. Marhon, Daniel D. De Carvalho, John E. Dick, Gary D. Bader, Kristin J. Hope
Publikováno v:
Blood. 140:992-1008
Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136c7c0a928ffbfa41375aa2c6c2a365
https://doi.org/10.1182/blood.2021014698
https://doi.org/10.1182/blood.2021014698
Autor:
Carys S. Johnson, Kendig Sham, Serena Belluschi, Xiaonan Wang, Winnie Lau, Kerstin B. Kaufmann, Gabriela Krivdova, Emily F. Calderbank, Nicole Mende, Jessica McLeod, Giovanna Mantica, Matthew J. Williams, Charlotte Grey-Wilson, Michael Drakopoulos, Shubhankar Sinha, Evangelia Diamanti, Christina Basford, Anthony R. Green, Nicola K. Wilson, Steven J. Howe, John E. Dick, Bertie Göttgens, Natalie Francis, Elisa Laurenti
Loss of long-term haematopoietic stem cell function (LT-HSC) hampers the success ofex vivoHSC gene therapy and expansion procedures, but the kinetics and the mechanisms by which this occurs remain incompletely characterized. Here through time-resolve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30ea449c3cf6457e4ebfe0569ef3fb6
https://doi.org/10.1101/2022.11.17.516906
https://doi.org/10.1101/2022.11.17.516906
Autor:
Gabriela Krivdova, Brian Yee, Stefan Aigner, Martino Gabra, Alexander Shishkin, Long Nguyen, Jessica L McLeod, Leah Carley, Leonardo Salmena, Lorien Shakib, Mark D. Minden, Eric L Van Nostrand, Gene W. Yeo, Eric R. Lechman, John E. Dick
Publikováno v:
Blood. 140:8684-8685
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::394d02669a48fa2e472b54180344fe06
https://doi.org/10.1182/blood-2022-169849
https://doi.org/10.1182/blood-2022-169849
Autor:
Gabriela Krivdova, Veronique Voisin, Erwin M. Schoof, Sajid A. Marhon, Alex Murison, Jessica L. McLeod, Martino M. Gabra, Andy G.X. Zeng, Stefan Aigner, Brian A. Yee, Alexander A. Shishkin, Eric L. Van Nostrand, Karin G. Hermans, Aaron C. Trotman-Grant, Nathan Mbong, James A. Kennedy, Olga I. Gan, Elvin Wagenblast, Daniel D. De Carvalho, Leonardo Salmena, Mark D. Minden, Gary D. Bader, Gene W. Yeo, John E. Dick, Eric R. Lechman
Publikováno v:
Cell reports. 38(10)
Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells (HSCs) point to shared core stemness properties. However, discordance between mRNA and protein signatures highlights an important role for post-transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4580a84d4d8eb2b76e4d4bafec775df2
https://pubmed.ncbi.nlm.nih.gov/35263585
https://pubmed.ncbi.nlm.nih.gov/35263585
Autor:
Veronique Voisin, Erwin M. Schoof, Eric R. Lechman, Nathan Mbong, Andy G.X. Zeng, James A. Kennedy, Daniel D. De Carvalho, Gabriela Krivdova, Olga I. Gan, Gene W. Yeo, Leonardo Salmena, Gary D. Bader, John E. Dick, Elvin Wagenblast, Martino Gabra, Eric L. Van Nostrand, Mark D. Minden, Alexander Murison, Brian A. Yee, Stefan Aigner, Jessica McLeod, Sajid A. Marhon, Karin G. Hermans, Alexander A. Shishkin, Aaron Trotman-Grant
SUMMARYGene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells (HSC) point to shared core stemness properties. However, discordance between mRNA and protein signatures underscores an important role for post-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e3b525e4acdf9d20d00d19dc43385d
https://doi.org/10.1101/2021.07.30.454489
https://doi.org/10.1101/2021.07.30.454489
Autor:
Sasan Zandi, Kerstin B. Kaufmann, Mike J. Tsay, Laura García-Prat, Stanley W.K. Ng, Chiara Pastrello, Mark D. Minden, John E. Dick, Gabriela Krivdova, Jean C.Y. Wang, Elvin Wagenblast, Eric R. Lechman, Stephanie Z. Xie, Qiang Liu, Peter van Galen, Igor Jurisica, Amanda Mitchell, Erno Wienholds, Shin-ichiro Takayanagi, Christian A. Cumbaa
Publikováno v:
Blood. 133:2198-2211
There is a growing body of evidence that the molecular properties of leukemia stem cells (LSCs) are associated with clinical outcomes in acute myeloid leukemia (AML), and LSCs have been linked to therapy failure and relapse. Thus, a better understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261572ea9298c8308e82a07da91900cb
https://doi.org/10.1182/blood-2018-10-881441
https://doi.org/10.1182/blood-2018-10-881441
Autor:
Gabriela Krivdova, Florin Schneiter, Jocelyn Chen, Sabrina A. Smith, Jessica McLeod, John E. Dick, Andy G.X. Zeng, Veronique Voisin, M. C. Shoong, Stephanie Z. Xie, Michelle Chan-Seng-Yue, Kerstin B. Kaufmann, D. Parris, S.-I. Takayanagi, Laura García-Prat, Timm Schroeder, K. Pan, Olga I. Gan, Alex Murison, Mathieu Lupien, Elvin Wagenblast, W. Wang, K. Gupta
SummaryIt is critical to understand how quiescent long-term hematopoietic stem cells (LT-HSC) sense demand from daily and stress-mediated cues and transition into bioenergetically active progeny to differentiate and meet these cellular needs. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759f2155621265901831dd9d12777bff
https://doi.org/10.1101/2021.02.24.432720
https://doi.org/10.1101/2021.02.24.432720
Autor:
Alex Murison, Andy G.X. Zeng, Mathieu Lupien, Elvin Wagenblast, Veronique Voisin, Stephanie Z. Xie, Darrien Parris, Florin Schneiter, Kerstin B. Kaufmann, Weijia Wang, Laura García-Prat, Sabrina A. Smith, Kinam Gupta, Michelle C. Shoong, Gabriela Krivdova, Olga I. Gan, Jocelyn Chen, Kristele Pan, Timm Schroeder, Shin-Ichiro Takayanagi, Jessica McLeod, John E. Dick, Michelle Chan-Seng-Yue
Publikováno v:
Cell Stem Cell, 28 (10)
It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-HSCs) sense demand from daily and stress-mediated cues and then transition into bioenergetically active progeny to differentiate and meet these cellular needs. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd0a23292b3827801ed27929e2b92cd