Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Gabriela Gorelik"'
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c349d4421015ef9d90bd9fb76ccabec8
https://doi.org/10.1096/fasebj.2020.34.s1.04513
https://doi.org/10.1096/fasebj.2020.34.s1.04513
Publikováno v:
Clinical Immunology. 158:193-203
Genetic and environmental factors contribute to the onset and progression of lupus. CD4+ T cells from patients with active lupus show a decreased ERK signaling pathway, which causes changes in gene expression. The defect points to its upstream regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdfb1131cd177304190affea47f9a7b
https://doi.org/10.1016/j.clim.2015.03.017
https://doi.org/10.1016/j.clim.2015.03.017
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Lupus remains a poorly understood disease causing disability and early mortality in those affected. Familial clustering and the identification of genetic susceptibility loci indicate that genes contribute to lupus (1), but incomplete concordance in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71958f0ae2b737c27a86fa925daf67ed
https://doi.org/10.1002/art.38427
https://doi.org/10.1002/art.38427
Autor:
W. Joseph McCune, Punsisi Liyanarachchi, Tania Gonzalez-Rivera, Emily C. Somers, Bruce Richardson, Anura Hewagama, Faith M. Strickland, Dipak R. Patel, Gabriela Gorelik
Publikováno v:
Journal of Autoimmunity. 41:60-71
Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter’s Syndrome (XXY) develop lupus at approximately the same rate as women suggests that a second X chromosome contributes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d431ada51ad2063ab835821f636fc23a
https://doi.org/10.1016/j.jaut.2012.12.006
https://doi.org/10.1016/j.jaut.2012.12.006
Publikováno v:
Lupus (Los Angeles)
Objective: Lupus develops when genetically predisposed people encounter certain drugs or environmental agents causing oxidative stress such as infections and sun exposure, and then typically follows a chronic relapsing course with flares triggered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026643a04bf62364222713e2e3b6ba89
https://doi.org/10.35248/2684-1630.16.1.120
https://doi.org/10.35248/2684-1630.16.1.120
Publikováno v:
Arthritis & Rheumatism. 64:2964-2974
Objective CD4+ T cells from patients with active lupus have impaired ERK pathway signaling that decreases DNA methyltransferase expression, resulting in DNA demethylation, overexpression of immune genes, and autoimmunity. The ERK pathway defect is du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b05d2c42040a8275b8085498f71a4889
https://doi.org/10.1002/art.34503
https://doi.org/10.1002/art.34503
Autor:
Bruce Richardson, Gabriela Gorelik
Publikováno v:
Autoimmunity. 43:17-22
Systemic lupus erythematosus is a poorly understood autoimmune disease, characterized by autoantibodies to nuclear antigens and immune complex deposition in organs like the kidney. Current evidence indicates that a pathologic CD4+T cell subset, chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2e9cb8afaff2f1be3e33c94710656c
https://doi.org/10.3109/08916930903374832
https://doi.org/10.3109/08916930903374832
Publikováno v:
Journal of Leukocyte Biology. 87:137-145
Decreased ERK and JNK signaling in CD4+CD28− T cells decreases DNA methyltransferase levels causes demethylation and overexpression of genes normally suppressed by chromatin structure. An inflammatory and cytotoxic CD4+CD28– T cell subset infiltr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a82c72cf0aa61f19006b4c79862a9d
https://doi.org/10.1189/jlb.0809562
https://doi.org/10.1189/jlb.0809562
Autor:
Ailing Wu, Bruce C. Richardson, Anura Hewagama, Dhiman Basu, Faith M. Strickland, Gabriela Gorelik, Robert Hinderer, Sushma Yarlagadda, Mariana J. Kaplan, Ying Liu
Publikováno v:
The Journal of Immunology. 183:3481-3487
T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We found that stimulatory and inhibitory killer cell Ig-like receptor (KIR) genes are aberrantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2656cf4a4a7134b0f592e1c5dc64b3e
https://doi.org/10.4049/jimmunol.0900034
https://doi.org/10.4049/jimmunol.0900034
Autor:
Amr H. Sawalha, Donna Ray, Nicholas Knowlton, Jeanette Osban, Gabriela Gorelik, Bruce Richardson, Ryan Webb, Kent J. Johnson, Matlock A. Jeffries, Qianjin Lu
Publikováno v:
Genes & Immunity. 9:368-378
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against a host of nuclear antigens. The pathogenesis of lupus is incompletely understood. Environmental factors may play a role via altering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553e8d99a345bf22d24e1c736f116126
https://doi.org/10.1038/gene.2008.29
https://doi.org/10.1038/gene.2008.29