Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gabriela G. Cezar"'
Autor:
Paul R West, David G Amaral, Preeti Bais, Alan M Smith, Laura A Egnash, Mark E Ross, Jessica A Palmer, Burr R Fontaine, Kevin R Conard, Blythe A Corbett, Gabriela G Cezar, Elizabeth L R Donley, Robert E Burrier
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112445 (2014)
BackgroundThe diagnosis of autism spectrum disorder (ASD) at the earliest age possible is important for initiating optimally effective intervention. In the United States the average age of diagnosis is 4 years. Identifying metabolic biomarker signatu
Externí odkaz:
https://doaj.org/article/7b25d4b8938e4789983f5ab55ca1edee
Autor:
Paul R. West, Ashley M. Poenitzsch, Kevin R. Conard, Jessica A. Palmer, Gabriela G. Cezar, Susan M. Smith
Publikováno v:
Alcoholism: Clinical and Experimental Research. 36:1314-1324
Fetal alcohol spectrum disorders (FASD) are a leading cause of neurodevelopmental disability. The mechanisms underlying FASD are incompletely understood, and biomarkers to identify those at risk are lacking. Here, we perform metabolomic analysis of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac01be4b01f5e712cb0efb5a8ea4de46
https://doi.org/10.1111/j.1530-0277.2011.01732.x
https://doi.org/10.1111/j.1530-0277.2011.01732.x
Autor:
Jessica A. Palmer, Andrew Smith, Nicole Kleinstreuer, Thomas B. Knudsen, Paul R. West, Kevin R. Conard, Burr R. Fontaine, David J. Dix, Gabriela G. Cezar, Elizabeth L.R. Donley, A.M. Weir-Hauptman
Publikováno v:
Toxicology and Applied Pharmacology. 257:111-121
Metabolomics analysis was performed on the supernatant of human embryonic stem (hES) cell cultures exposed to a blinded subset of 11 chemicals selected from the chemical library of EPA's ToxCast™ chemical screening and prioritization research proje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ec69c6e93600e69a2ba972b9a0593e
https://doi.org/10.1016/j.taap.2011.08.025
https://doi.org/10.1016/j.taap.2011.08.025
Autor:
Alan M. Smith, Gabriela G. Cezar, Fred H. Gage, Maria C. Marchetto, Yangling Mu, Alysson R. Muotri
Publikováno v:
Cell Stem Cell. 3(6):649-657
Summary Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. ALS can be induced by mutations in the superoxide dismutase 1 gene (SOD1). Evidence for the non-cell-autonomous nature of ALS emerged from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b09e09b0704ec72a703b061a0dbcab
Autor:
Alysson R. Muotri, James F. Brown, Marian S. Piekarczyk, Fred H. Gage, Jessica A. Quam, Gabriela G. Cezar, Alan M. Smith, Guilherme J. M. Rosa
Publikováno v:
Stem Cells and Development. 16:869-882
Metabolomics enables the discovery of small molecules that may serve as candidate biomarkers of pharmacological efficacy or toxicity. Biochemical pathways of human development are likely active in human embryonic stem (hES) cells and derivatives, sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb47063197991f88de77f383a17584d
https://doi.org/10.1089/scd.2007.0022
https://doi.org/10.1089/scd.2007.0022
Autor:
Gabriela G. Cezar
Publikováno v:
Current Opinion in Chemical Biology. 11:405-409
Few scientific achievements have received such irresistible attention from scientists, clinicians, and the general public as the ability of human embryonic stem (hES) cells to differentiate into functional cell types for regenerative medicine. The mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3029d1f4323af07ed8eaab3641c5c8
https://doi.org/10.1016/j.cbpa.2007.05.033
https://doi.org/10.1016/j.cbpa.2007.05.033
Autor:
Gabriela G. Cezar
Publikováno v:
International Journal of Pharmaceutical Medicine. 20:107-114
The predictive toxicity of chemicals to humans is largely based on scientific investigation in animal models. However, interspecies variability impacts the ability of certain animal models to emulate human response, which ultimately influences attrit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cebc20d050cdc18268aeb057c92b3f8
https://doi.org/10.2165/00124363-200620020-00004
https://doi.org/10.2165/00124363-200620020-00004
Autor:
Gabriela G. Cezar, Mary B. Bauchmann, Anthony J. Milici, Gretchen E Beckius, Khuram W. Chaudhary, Nestor X. Barrezueta, John D. McNeish, William L. Blake, John E. Hambor, Donald B. Stedman, Anthony Bahinski
Publikováno v:
Toxicological Sciences. 90:149-158
Embryonic stem (ES) cells offer unprecedented opportunities for in vitro drug discovery and safety assessment of compounds. Cardiomyocytes derived from ES cells enable development of predictive cardiotoxicity models to increase the safety of novel dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20ef6b9eb9ab5f70ca2b77d98fa163e
https://doi.org/10.1093/toxsci/kfj078
https://doi.org/10.1093/toxsci/kfj078
Autor:
Neal L. First, Gabriela G. Cezar, Kenneth J. Eilertsen, Marisa S. Bartolomei, Michael D. Bishop, Erik J. Forsberg
Publikováno v:
Biology of Reproduction. 68:1009-1014
To gain a better understanding of global methylation differences associated with development of nuclear transfer (NT)-generated cattle, we analyzed the genome-wide methylation status of spontaneously aborted cloned fetuses, cloned fetuses, and adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f644f31abcb3f53e792abc1d46baafef
https://doi.org/10.1095/biolreprod.102.010181
https://doi.org/10.1095/biolreprod.102.010181
Autor:
Elizabeth L.R. Donley, Burr R. Fontaine, Alan M. Smith, Laura A. Egnash, Gabriela G. Cezar, David G. Amaral, Preeti Bais, Kevin R. Conard, Jessica A. Palmer, Mark E. Ross, Robert E. Burrier, Blythe A. Corbett, Paul R. West
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e112445 (2014)
PLoS ONE, Vol 9, Iss 11, p e112445 (2014)
BackgroundThe diagnosis of autism spectrum disorder (ASD) at the earliest age possible is important for initiating optimally effective intervention. In the United States the average age of diagnosis is 4 years. Identifying metabolic biomarker signatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd5bf57ed0b48ea0033304bbff8b9be
https://pubmed.ncbi.nlm.nih.gov/25380056
https://pubmed.ncbi.nlm.nih.gov/25380056