Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gabriela Echeverría‐Garcés"'
Autor:
Andrés López-Cortés, Alejandro Cabrera-Andrade, Gabriela Echeverría-Garcés, Paulina Echeverría-Espinoza, Micaela Pineda-Albán, Nicole Elsitdie, José Bueno-Miño, Carlos M. Cruz-Segundo, Julian Dorado, Alejandro Pazos, Humberto Gonzáles-Díaz, Yunierkis Pérez-Castillo, Eduardo Tejera, Cristian R. Munteanu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract The druggable proteome refers to proteins that can bind to small molecules with appropriate chemical affinity, inducing a favorable clinical response. Predicting druggable proteins through screening and in silico modeling is imperative for d
Externí odkaz:
https://doaj.org/article/962d3219bab946fab5bbd952340574c8
Autor:
Gabriela Echeverría-Garcés, María José Ramos-Medina, Ariana González, Rodrigo Vargas, Alejandro Cabrera-Andrade, Isaac Armendáriz-Castillo, Jennyfer M. García-Cárdenas, David Ramírez-Sánchez, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María Paula Freire, Belén Ocaña-Paredes, Sebastián Rivera-Orellana, Santiago Guerrero, Luis A. Quiñones, Andrés López-Cortés
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37488- (2024)
Based on data from the Global Cancer Statistics 2022, lung cancer stands as the most lethal cancer worldwide, with age-adjusted incidence and mortality rates of 23.6 and 16.9 per 100,000 people, respectively. Despite significant strides in precision
Externí odkaz:
https://doaj.org/article/1dbf8f232daf45ba90fd8fea86cd851c
Autor:
Gabriela Echeverría-Garcés, María José Ramos-Medina, Rodrigo Vargas, Alejandro Cabrera-Andrade, Adriana Altamirano-Colina, María Paula Freire, Juliana Montalvo-Guerrero, Sebastián Rivera-Orellana, Paulina Echeverría-Espinoza, Luis A. Quiñones, Andrés López-Cortés
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Gastric cancer is one of the most prevalent types of cancer worldwide. The World Health Organization (WHO), the International Agency for Research on Cancer (IARC), and the Global Cancer Statistics (GLOBOCAN) reported an age standardized
Externí odkaz:
https://doaj.org/article/4fc8564a1a65463ea7ee156e96e53092
Autor:
Belén Ocaña-Paredes, Sebastián Rivera-Orellana, David Ramírez-Sánchez, Juliana Montalvo-Guerrero, María Paula Freire, Samantha Espinoza-Ferrao, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María José Ramos-Medina, Gabriela Echeverría-Garcés, Danilo Granda-Moncayo, Andrea Jácome-Alvarado, María Gabriela Andrade, Andrés López-Cortés
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. This insight h
Externí odkaz:
https://doaj.org/article/6aeb0f23da1d4129ad4c7d906668331a
Autor:
Andy Pérez-Villa, Gabriela Echeverría-Garcés, María José Ramos-Medina, Lavanya Prathap, Mayra Martínez-López, David Ramírez-Sánchez, Jennyfer M. García-Cárdenas, Isaac Armendáriz-Castillo, Santiago Guerrero, Clara Paz, Andrés López-Cortés
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these rhythms can trigger insufficient neurocognitive development, insomnia, mental disorders, cardiovascular diseases, me
Externí odkaz:
https://doaj.org/article/e92efdf3f4fd432384e5c7a6378c31c0
Autor:
María José Ramos-Medina, Gabriela Echeverría-Garcés, Nikolaos C. Kyriakidis, Ángela León Cáceres, Esteban Ortiz-Prado, Jhommara Bautista, Álvaro A. Pérez-Meza, Andrea Abad-Sojos, Karol Nieto-Jaramillo, Samantha Espinoza-Ferrao, Belén Ocaña-Paredes, Andrés López-Cortés
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23682- (2024)
Cardiovascular diseases are the leading cause of death worldwide, with heart failure being a complex condition that affects millions of individuals. Single-nucleus RNA sequencing has recently emerged as a powerful tool for unraveling the molecular me
Externí odkaz:
https://doaj.org/article/e0e718d001024f43bae9c6fd348ce604
Autor:
Andrés López-Cortés, Lavanya Prathap, Esteban Ortiz-Prado, Nikolaos C. Kyriakidis, Ángela León Cáceres, Isaac Armendáriz-Castillo, Antonella Vera-Guapi, Verónica Yumiceba, Katherine Simbaña-Rivera, Gabriela Echeverría-Garcés, Jennyfer M. García-Cárdenas, Andy Pérez-Villa, Patricia Guevara-Ramírez, Andrea Abad-Sojos, Jhommara Bautista, Lourdes Puig San Andrés, Nelson Varela, Santiago Guerrero
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Many primary-tumor subregions exhibit low levels of molecular oxygen and restricted access to nutrients due to poor vascularization in the tissue, phenomenon known as hypoxia. Hypoxic tumors are able to regulate the expression of certain gen
Externí odkaz:
https://doaj.org/article/232a46b4edde474ab4010ae0d3483ad3
Autor:
Aimeé Salas-Hernández, Macarena Galleguillos, Matías Carrasco, Andrés López-Cortés, María Ana Redal, Dora Fonseca-Mendoza, Patricia Esperón, Farith González-Martínez, Ismael Lares-Asseff, Alberto Lazarowski, Verónica Loera-Castañeda, Diadelis Remírez, Matías F. Martínez, Rodrigo Vargas, Fabricio Rios-Santos, Antonio Macho, Juan P. Cayún, Germán R. Perez, Carolina Gutierrez, Leslie C. Cerpa, Tamara Leiva, Susan Calfunao, Lesly Xajil, Christopher Sandoval, Marcelo Suárez, Ariana Gonzalez, Gabriela Echeverría-Garcés, Luis Sullón-Dextre, Eugenia Cordero-García, Alexis R. Morales, Andrea Avendaño, Enrique Sánchez, Laura C. Bastone, Cesar Lara, Patricia Zuluaga-Arias, Ana María Soler, Julio Da Luz, Gabriela Burgueño-Rodríguez, Marcelo Vital, Elizabeth Reyes-Reyes, Alexander Huaccha, Yeimy V. Ariza, Naomi Tzul, Ana L. Rendón, Roberto Serrano, Larissa Acosta, Angelo Motta-Pardo, Leonardo Beltrán-Angarita, Erika Brand, Miguel A. Jiménez, Gladys Maribel Hidalgo-Lozada, Marina M. J. Romero-Prado, Karla Escobar-Castro, Mariel Umaña-Rivas, Juan D. Vivas, Paola Lagos, Yineth Ballén Martínez, Sharleth Quesada, Camila Calfio, Maria L. Arias, María A. Lavanderos, Dante D. Cáceres, Alberto Salazar-Granara, Nelson M. Varela, Luis A. Quiñones
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx in the Latin American and the Caribbean (LAC) region remains scarce, with limited information in some populations. Thus, extrapolations are complicated, e
Externí odkaz:
https://doaj.org/article/cddef7cc0b5d4422b6589bf43ce85f02
Autor:
Andrés López-Cortés, Santiago Guerrero, Esteban Ortiz-Prado, Verónica Yumiceba, Antonella Vera-Guapi, Ángela León Cáceres, Katherine Simbaña-Rivera, Ana María Gómez-Jaramillo, Gabriela Echeverría-Garcés, Jennyfer M. García-Cárdenas, Patricia Guevara-Ramírez, Alejandro Cabrera-Andrade, Lourdes Puig San Andrés, Doménica Cevallos-Robalino, Jhommara Bautista, Isaac Armendáriz-Castillo, Andy Pérez-Villa, Andrea Abad-Sojos, María José Ramos-Medina, Ariana León-Sosa, Estefanía Abarca, Álvaro A. Pérez-Meza, Karol Nieto-Jaramillo, Andrea V. Jácome, Andrea Morillo, Fernanda Arias-Erazo, Luis Fuenmayor-González, Luis Abel Quiñones, Nikolaos C. Kyriakidis
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-19. Respiratory failure is the main cause of death in severe COVID-19 patients, and the host inflammatory response at the lungs remains poorly understood.Meth
Externí odkaz:
https://doaj.org/article/e8b07b23be824df88651bfffed4353ac
Publikováno v:
Biology, Vol 11, Iss 6, p 894 (2022)
The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by the SMN1 and SMN2 genes. It is one
Externí odkaz:
https://doaj.org/article/94000a3c10b24a45b2eb50dceeed7ce9