Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Gabriela Da Silva Xavier"'
Autor:
Tiago Dantas, Carla M. C. Abreu, Maria J. G. De-Castro, Ana Rita Grosso, Joao de Sousa Valente, Gabriela da Silva Xavier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/3d067a36984545c7bcbfd2ca49f46a08
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The propensity to develop type 2 diabetes (T2D) is known to have both environmental and hereditary components. In those with a genetic predisposition to T2D, it is widely believed that elevated concentrations of circulatory long-chain fatty acids (LC
Externí odkaz:
https://doaj.org/article/81169785512c4f0fbff7ae0b8a14d48d
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/150d3f3eb491404bbd786933f04596d7
Autor:
Katrina Viloria, Daniela Nasteska, Linford J.B. Briant, Silke Heising, Dean P. Larner, Nicholas H.F. Fine, Fiona B. Ashford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E. MacDonald, Ildem Akerman, Gareth G. Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, Martin Hewison, David J. Hodson
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107761- (2020)
Summary: Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although DBP serum levels,
Externí odkaz:
https://doaj.org/article/4961e1cbcd0b42b7a385bb7cadbfb0b4
Autor:
Mariana Alves Ribeiro, Jorge Soares Lyra, Ricardo Akiyoshi Nakamura, Nathália de Oliveira Santana, Gabriela da Silva Xavier, Geovana Logrado de Moares
Publikováno v:
Revista Brasileira de Cancerologia, Vol 66, Iss 1 (2020)
Introdução: O câncer de próstata e considerado a neoplasia maligna mais comum que acomete homens em todas as Regiões do pais, a exceção do câncer de pele não melanoma. Se diagnosticado e tratado precocemente, o câncer de próstata tem alta
Externí odkaz:
https://doaj.org/article/b3b66e437703478397562ebca63958cb
Autor:
Gao Sun, Gabriela da Silva Xavier, Tracy Gorman, Claire Priest, Antonia Solomou, David J. Hodson, Marc Foretz, Benoit Viollet, Pedro-Luis Herrera, Helen Parker, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne, Christophe Magnan, Anna Marley, Guy A. Rutter
Publikováno v:
Molecular Metabolism, Vol 4, Iss 4, Pp 277-286 (2015)
Aims/Hypothesis: Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase AMP-activated protein kinas
Externí odkaz:
https://doaj.org/article/4f54fb1ea32f4d228578aa597d3cc524
Autor:
Gabriela da Silva Xavier, Guy A. Rutter, Frédérique Diraison, Chrysovalantis Andreolas, Isabelle Leclerc
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 11, Pp 2482-2491 (2006)
Pancreatic β-cell dysfunction is central to the pathogenesis of type 2 diabetes and may involve secretory failure through glucolipotoxity. The relative importance of the transcription factors carbohydrate-responsive element binding protein (ChREBP),
Externí odkaz:
https://doaj.org/article/4d29dd48fdd54b4b84eb5ea0adc87db4
Autor:
Angeles Mondragon, Daniel Davidsson, Styliana Kyriakoudi, Annika Bertling, Rosa Gomes-Faria, Patrizia Cohen, Stephen Rothery, Pauline Chabosseau, Guy A Rutter, Gabriela da Silva Xavier
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104873 (2014)
AIMS:Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP4) inhibitors improve glucose tolerance by still incompletely understood mechanisms. Each class of antihyperglycemic drugs has also been proposed to increase pancre
Externí odkaz:
https://doaj.org/article/e6ab046b4e0344f6b795483d2ba6a1a6
Publikováno v:
Journal of Diabetes Research, Vol 2013 (2013)
More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understand
Externí odkaz:
https://doaj.org/article/fe119eb8348c49b18793e36a4c56ad0b
Publikováno v:
Journal of Molecular Biology. 432:1395-1406
Metabolic and secretory heterogeneity are fundamental properties of pancreatic islet β cells. Emerging data suggest that stable differences in the transcriptome and proteome of individual cells may create cellular hierarchies, which, in turn, establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd84da15660729febd31058e0401f183
https://doi.org/10.1016/j.jmb.2019.08.005
https://doi.org/10.1016/j.jmb.2019.08.005