Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Gabriela B. Iwanski"'
Publikováno v:
The Scientific World Journal, Vol 10, Pp 413-418 (2010)
Cucurbitacins and their derivatives are triterpenoids found in medicinal plants known for their diverse pharmacological and biological activities, including anticancer effects, throughout human history. Although initial attention to cucurbitacin as a
Externí odkaz:
https://doaj.org/article/b42aeaef31b7488db773dd579015bd01
Autor:
H. Phillip Koeffler, Jonathan W. Said, Wei Dong Xie, Melvin Toh, Dong Yin, Jee Hoon Song, Sam Abbassi, Patricia Lin, Ryoko Okamoto, Ngan B. Doan, Gabriela B. Iwanski, Nils H. Thoennissen
Pancreatic cancer is an aggressive malignancy that is generally refractory to chemotherapy, thus posing experimental and clinical challenges. In this study, the antiproliferative effect of the triterpenoid compound cucurbitacin B was tested in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::277fc126b58f18401825685e4a450820
https://doi.org/10.1158/0008-5472.c.6499088.v1
https://doi.org/10.1158/0008-5472.c.6499088.v1
Autor:
H. Phillip Koeffler, Jonathan W. Said, Wei Dong Xie, Melvin Toh, Dong Yin, Jee Hoon Song, Sam Abbassi, Patricia Lin, Ryoko Okamoto, Ngan B. Doan, Gabriela B. Iwanski, Nils H. Thoennissen
Supplementary Table 1 from Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e7a2103ddec287cdf6e2b17de8f2ce
https://doi.org/10.1158/0008-5472.22379006.v1
https://doi.org/10.1158/0008-5472.22379006.v1
Autor:
Torsten Haferlach, Ruben A. Mesa, Ayalew Tefferi, Tamara Weiss, Maya Koren-Michowitz, Nils H. Thoennissen, Norihiko Kawamata, D. Gary Gilliland, Sophie Raynaud, Utz Krug, Dhong Hyun Lee, Lee Yung Shih, Gabriela B. Iwanski, Terra L. Lasho, Daniel Nowak, Arnon Nagler, Seishi Ogawa, Carsten Müller-Tidow, H. Phillip Koeffler, Motohiro Kato, Masashi Sanada
Publikováno v:
Blood. 115:2882-2890
Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and primary myelofibrosis show an inherent tendency for transformation into leukemia (MPN-blast phase), which is hypothesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c56c34f3dadf1f953e0ea48a8b0809
https://doi.org/10.1182/blood-2009-07-235119
https://doi.org/10.1182/blood-2009-07-235119
Autor:
Dhong Hyun Lee, Gabriela B. Iwanski, Shlomit En-Gal, Brandon Castor, Marco Vogt, Melvin Toh, Nils H. Thoennissen, Ngan B. Doan, Jonathan W. Said, H. Phillip Koeffler, Carsten Bokemeyer
Publikováno v:
British Journal of Pharmacology. 160:998-1007
Background and purpose: Pancreatic cancer is a highly aggressive malignancy, and improvement in systemic therapy is necessary to treat this frequently encountered metastatic disease. The current targeted agents used in combination with gemcitabine im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6db8550d9f545340b1ac68f7690fec
https://doi.org/10.1111/j.1476-5381.2010.00741.x
https://doi.org/10.1111/j.1476-5381.2010.00741.x
Autor:
D T La, James O'Kelly, Andrew B. Leiter, Nils H. Thoennissen, Gabriela B. Iwanski, Daning Lu, Sam Abbassi, H P Koeffler, Beth Y. Karlan, Rajendra G. Mehta
Publikováno v:
Oncogene. 29:285-296
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is an ingredient of chili peppers with inhibitory effects against cancer cells of different origin. We examined the activity of capsaicin on breast cancer cells in vitro and in vivo. The drug potentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8743cc04ef802f7989c9addc6599c8d8
https://doi.org/10.1038/onc.2009.335
https://doi.org/10.1038/onc.2009.335
Autor:
Evgeny Klyuchnikov, Ulrike Bacher, Axel R. Zander, Gabriela B. Iwanski, Nicolaus Kröger, Tatjana Zabelina, Andreas Hochhaus, Walter Fiedler, Susanne Schnittger, Philippe Schafhausen, Francis Ayuk, Tim H. Brümmendorf, Sunday Ocheni
Publikováno v:
Leukemia & Lymphoma. 50:551-558
Recently, higher extramedullary relapse rates following allogeneic stem cell transplantation (SCT) in myeloid malignancies were reported e.g. because of selection of poor-risk patients. We analysed five consecutive patients with post-transplant extra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8a077d765117c25ea998029999e76c
https://doi.org/10.1080/10428190902755513
https://doi.org/10.1080/10428190902755513
Publikováno v:
Neoplastic Diseases of the Blood ISBN: 9781461437635
Therapy-related acute myelogenous leukemia (t-AML) remains difficult to distinguish from de novo leukemia, and the overall incidence of t-AML is expected to increase with the successful management of other malignancies. Cytotoxic chemotherapy and rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac9c4704bb88a7e746bd509f0f584e1a
https://doi.org/10.1007/978-1-4614-3764-2_24
https://doi.org/10.1007/978-1-4614-3764-2_24
Autor:
Jonathan W. Said, Charles Forscher, Nils H. Thoennissen, H. Phillip Koeffler, Catherine B. Goff, Gabriela B. Iwanski, Ngan B. Doan, Dhong Hyun Lee
We investigated the use of cucurbitacin B, a plant-derived tetracyclic triterpenoid, as a single agent or in combination with methotrexate (MTX) for human osteosarcoma (OS) treatment. Cucurbitacin B showed antiproliferative activity against seven hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e019c47277d278c48cb3ffd1c18efdb5
https://europepmc.org/articles/PMC4925102/
https://europepmc.org/articles/PMC4925102/
Autor:
Gabriela B, Iwanski, Dhong H, Lee, Shlomit, En-Gal, Ngan B, Doan, Brandon, Castor, Marco, Vogt, Melvin, Toh, Carsten, Bokemeyer, Jonathan W, Said, Nils H, Thoennissen, H Phillip, Koeffler
Publikováno v:
British journal of pharmacology. 160(4)
Pancreatic cancer is a highly aggressive malignancy, and improvement in systemic therapy is necessary to treat this frequently encountered metastatic disease. The current targeted agents used in combination with gemcitabine improved objective respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12d7eebb4bde59011af76c18b915719f
https://pubmed.ncbi.nlm.nih.gov/20590594
https://pubmed.ncbi.nlm.nih.gov/20590594