Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Gabriela Aust"'
Autor:
Lixiazi He, Christian Arnold, Judith Thoma, Christian Rohde, Maksim Kholmatov, Swati Garg, Cheng‐Chih Hsiao, Linda Viol, Kaiqing Zhang, Rui Sun, Christina Schmidt, Maike Janssen, Tara MacRae, Karin Huber, Christian Thiede, Josée Hébert, Guy Sauvageau, Julia Spratte, Herbert Fluhr, Gabriela Aust, Carsten Müller‐Tidow, Christof Niehrs, Gislene Pereira, Jörg Hamann, Motomu Tanaka, Judith B Zaugg, Caroline Pabst
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-22 (2022)
Abstract The heterogeneous response of acute myeloid leukemia (AML) to current anti‐leukemic therapies is only partially explained by mutational heterogeneity. We previously identified GPR56 as a surface marker associated with poor outcome across g
Externí odkaz:
https://doaj.org/article/268002c07dd34175a0c516fb03b86c27
Autor:
Leyu Zheng, Moujie Rang, Carolin Fuchs, Annette Keß, Mandy Wunsch, Julia Hentschel, Cheng-Chih Hsiao, Christian Kleber, Georg Osterhoff, Gabriela Aust
Publikováno v:
Cells, Vol 12, Iss 22, p 2657 (2023)
Trauma triggers a rapid innate immune response to aid the clearance of damaged/necrotic cells and their released damage-associated molecular pattern (DAMP). Here, we monitored the expression of EMR2/ADGRE2, involved in the functional regulation of in
Externí odkaz:
https://doaj.org/article/294a328a25f94cbca16c7587419d905f
Autor:
Romy Winkler, Marianne Quaas, Stefan Glasmacher, Uwe Wolfrum, Torsten Thalheim, Jörg Galle, Knut Krohn, Thomas M. Magin, Gabriela Aust
Publikováno v:
Cells, Vol 12, Iss 13, p 1677 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/312d4866bd2a42a5b6bfcc161180f2f2
Autor:
Georgi Atanasov, Karoline Dino, Katrin Schierle, Corinna Dietel, Gabriela Aust, Johann Pratschke, Daniel Seehofer, Moritz Schmelzle, Hans-Michael Hau
Publikováno v:
World Journal of Surgical Oncology, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Tumor escape mechanisms mediated in the tumor microenvironment can significantly reduce the capacity of the anti-tumor function of the immune system. TIE2-expressing monocytes (TEMs), related angiopoietins, and tumor necrosis are
Externí odkaz:
https://doaj.org/article/fe55f3c3873843b8a704b6f384104ba3
Publikováno v:
Bioengineering, Vol 10, Iss 1, p 50 (2022)
The implementation of stem-cell-based organoid culture more than ten years ago started a development that created new avenues for diagnostic analyses and regenerative medicine. In parallel, computational modelling groups realized the potential of thi
Externí odkaz:
https://doaj.org/article/d67d2df470ad4488b37f91cfaaed4f96
Autor:
Romy Winkler, Marianne Quaas, Stefan Glasmacher, Uwe Wolfrum, Torsten Thalheim, Jörg Galle, Knut Krohn, Thomas M. Magin, Gabriela Aust
Publikováno v:
Cells, Vol 11, Iss 19, p 3151 (2022)
Among the 33 human adhesion G-protein-coupled receptors (aGPCRs), a unique subfamily of GPCRs, only ADGRF4, encoding GPR115, shows an obvious skin-dominated transcriptomic profile, but its expression and function in skin is largely unknown. Here, we
Externí odkaz:
https://doaj.org/article/73a65f99dd5c409cb55b350424920c64
Autor:
Georgi Atanasov, Karoline Dino, Katrin Schierle, Corinna Dietel, Gabriela Aust, Johann Pratschke, Daniel Seehofer, Moritz Schmelzle, Hans-Michael Hau
Publikováno v:
World Journal of Surgical Oncology, Vol 17, Iss 1, Pp 1-8 (2019)
Abstract Background Anti-tumour immune competence has an impact in hepatocarcinogenesis and success of anti-cancer therapies. Tumour-infiltrating lymphocytes (TILs) and monocytes/macrophages (TAMs) are proposed to have significance in cancer. However
Externí odkaz:
https://doaj.org/article/376f30ead5cf48409ec72296da63db0a
Autor:
Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R. Schweiger, Gabriela Aust
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide hist
Externí odkaz:
https://doaj.org/article/f3652322832b4382953c498b1a202463
Autor:
Deva K. Kusuluri, Baran E. Güler, Barbara Knapp, Nicola Horn, Karsten Boldt, Marius Ueffing, Gabriela Aust, Uwe Wolfrum
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102283- (2021)
Summary: VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1
Externí odkaz:
https://doaj.org/article/232b824b2ea04d888eca98f77fd93557
Publikováno v:
Cells, Vol 11, Iss 9, p 1538 (2022)
Tumorigenesis is a multistep process, during which cells acquire a series of mutations that lead to unrestrained cell growth and proliferation, inhibition of cell differentiation, and evasion of cell death. Growing tumors stimulate angiogenesis, prov
Externí odkaz:
https://doaj.org/article/82306a21adad4dc8b686154e814ae0ec