MDR1 Genetic Polymorphism Does Not Modify either Cell Permissiveness to HIV-1 or Disease Progression before Treatment

Autor: Matthias Egger, Gabriela Bleiber, Catia Marzolini, Carlos Suarez, Amalio Telenti, Raquel Martinez, Margaret T May

Publikováno v: Journal of Infectious Diseases, vol. 189, no. 4, pp. 583-6
Bleiber, Gabriela; May, Margaret; Suarez, Carlos; Martinez, Raquel; Marzolini, Catia; Egger, Matthias; Telenti, Amalio (2004). MDR1 Genetic Polymorphism Does Not Modify either Cell Permissiveness to HIV-1 or Disease Progression before Treatment. Journal of infectious diseases, 189(4), pp. 583-586. The University of Chicago Press 10.1086/380134

Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6ab7c955f2809ac199cdb80803c730
http://doc.rero.ch/record/301882/files/189-4-583.pdf

Host genetics of HIV-1 susceptibility

Autor: Gabriela Bleiber, Amalio Telenti

Publikováno v: Future Virology. 1:55-70

Susceptibility to HIV-1 and the rate of disease progression reflect the influence of the genetic diversity of the virus as well as the variation in host factors. The virus will co-evolve with the host, escaping and adapting to host-determined influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c71b75c90e4918a96ada1959afd4f789
https://doi.org/10.2217/17460794.1.1.55

Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients

Autor: Gabriela Bleiber, Olivia Keiser, Thierry Buclin, Amalio Telenti, Laurent A. Decosterd, Belle L. Lee, Hansjakob Furrer, Margalida Rotger, Sara Colombo, Jérôme Biollaz

Publikováno v: Pharmacogenetics and Genomics. 15:1-5

BACKGROUND: Efavirenz (EFV) and nevirapine (NVP) are metabolized by cytochrome P450 2B6 (CYP2B6). Allele 516 G>T (Gln172His) is associated with diminished activity of this isoenzyme, and may lead to differences in drug exposure. METHODS: We evaluated

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https://doi.org/10.1097/01213011-200501000-00001

Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1

Autor: Ying Qi, Lisa P. Jacobson, Mary Carrington, Frank Maldarelli, Galit Alter, Traci E. Yamashita, Randall C. Johnson, Gabriela Bleiber, Susan Buchbinder, David Vlahov, Arman Bashirova, Amalio Telenti, Holli B. Hutcheson, Stephen J. O'Brien, Jie Cheng, James J. Goedert, Margaret T May, Keith Hoots

Publikováno v: Journal of virology. 80(14)

Tumor susceptibility gene 101 ( TSG101 ) encodes a host cellular protein that is appropriated by human immunodeficiency virus type 1 (HIV-1) in the budding process of viral particles from infected cells. Variation in the coding or noncoding regions o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1eed522c83cc186e3fb7e30ace72b28
https://pubmed.ncbi.nlm.nih.gov/16809281

Efavirenz intoxication due to slow hepatic metabolism

Autor: M. Krause, Gabriela Bleiber, Barbara Hasse, Huldrych F. Günthard

Publikováno v: Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, vol. 40, no. 3, pp. e22-e23

We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eb3a8b2f83a7fdacfb6f4647260507
https://serval.unil.ch/notice/serval:BIB_94D5173C4402