E6/E7 Functional Differences among Two Natural Human Papillomavirus 18 Variants in Human Keratinocytes

Autor: Emily Montosa Nunes, Valéria Talpe-Nunes, João Simão Sobrinho, Silvaneide Ferreira, Vanesca de Souza Lino, Lara Termini, Gabriela Ávila Fernandes Silva, Enrique Boccardo, Luisa Lina Villa, Laura Sichero

Publikováno v: Viruses, Vol 13, Iss 6, p 1114 (2021)

It is suggested that HPV-18 variants from the A lineage have higher oncogenic potential compared to B variants. Some studies show uneven distribution of HPV-18 variants in cervical adenocarcinomas and squamous cell carcinomas. Regarding HPV-18 varian

Externí odkaz: https://doaj.org/article/13a3fa2f3b0d479ebb9cabfb02f0cbcf

High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma

Autor: Maria Cecília Ramiro Talarico, Rafaella Almeida Lima Nunes, Gabriela Ávila Fernandes Silva, Larissa Bastos Eloy da Costa, Marcella Regina Cardoso, Sérgio Carlos Barros Esteves, Luis Otávio Zanatta Sarian, Luiz Carlos Zeferino, Lara Termini

Publikováno v: Antioxidants, Vol 10, Iss 5, p 724 (2021)

High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cervical cancer. This study aims to determine whether SOD2 protein expression is associated with the

Externí odkaz: https://doaj.org/article/13cfbfd8082744d2b7bbd82262e3f3c5

A positive HPV test with positive p16/Ki‐67 double staining in self‐sampled vaginal material is an accurate tool to detect women at risk for cervical cancer

Autor: Luisa L. Villa, Maricy Tacla, Rafaella Almeida Lima Nunes, Ana Paula Lepique, Noely Paula Cristina Lorenzi, Lara Termini, Edmund Chada Baracat, Gabriela Ávila Fernandes Silva, Adhemar Longatto-Filho, José Maria Soares-Júnior, Edson Santos Ferreira-Filho

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background The development of efficient strategies for managing high-risk human papillomavirus (HR-HPV)-positive women is a major challenge when human papillomavirus-based primary screening is being performed. The objectives of this study were to eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b0589ef3f0f33842e635d31ed8b207
https://doi.org/10.1002/cncy.22498

Oxidative stress: therapeutic approaches for cervical cancer treatment

Autor: Lara Termini, Rafaella Almeida Lima Nunes, Francisco Aguayo, Enrique Boccardo, Mirian Galliote Morale, Gabriela Ávila Fernandes Silva

Publikováno v: Clinics; v. 73 n. Suppl. 1 (2018); e548s
Clinics; Vol. 73 Núm. Suppl. 1 (2018); e548s
Clinics; Vol. 73 No. Suppl. 1 (2018); e548s
Clinics
Universidade de São Paulo (USP)
instacron:USP
Clinics, Vol 73, Iss suppl 1 (2018)

OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49187c2f17e0b4ffe32ccc230baa00dd
https://pubmed.ncbi.nlm.nih.gov/30540121

Abstract B69: Study of superoxide dismutase-2 protein in HPV-mediated cell transformation

Autor: Rafaella Almeida Lima Nunes, Gabriela Ávila Fernandes Silva, Lara Termini, Luisa L. Villa, Enrique Boccardo

Publikováno v: Clinical Cancer Research. 24:B69-B69

Oxidative stress reflects an imbalance in the maintenance of the intracellular redox state resulting in the accumulation of oxidant species that may contribute to tumorigenesis. The superoxide dismutase 2 protein (SOD2) contributes to cell homeostasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ed8ff838f92c1da095bdca561a2ed2e
https://doi.org/10.1158/1557-3265.tcm17-b69