Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Gabriela, Brumatti"'
Autor:
Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providin
Externí odkaz:
https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd
Publikováno v:
Biochemical Journal. 480:161-176
Chronic myeloid leukemia (CML) was considered for a long time one of the most hostile leukemia that was incurable for most of the patients, predominantly due to the extreme resistance to chemotherapy. Part of the resistance to cell death (apoptosis)
Autor:
Gustavo P. Amarante-Mendes, Aamir Rana, Tarcila Santos Datoguia, Nelson Hamerschlak, Gabriela Brumatti
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 215 (2022)
The constitutively active BCR-ABL1 tyrosine kinase, found in t(9;22)(q34;q11) chromosomal translocation-derived leukemia, initiates an extremely complex signaling transduction cascade that induces a strong state of resistance to chemotherapy. Targete
Externí odkaz:
https://doaj.org/article/93582f21368f4acba2d5ee7a24ad8718
Autor:
Nicole L. Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J. Sandow, Melanie K. Pudney, Mara Dottore, Richard J. D'Andrea, Angel F. Lopez, Paul G. Ekert, Hayley S. Ramshaw
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1067-1079 (2017)
Abstract: High expression of the α chain of the interleukin-3 receptor (IL-3Rα; CD123) is a hallmark of acute myeloid leukemia (AML) leukemic stem cells (LSCs). Elevated CD123 expression is part of the diagnostic immunophenotyping of myeloid leukem
Externí odkaz:
https://doaj.org/article/06a3c0aaf2114e6a92cf5ba3f7cf2246
Autor:
Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert
Publikováno v:
Viruses, Vol 12, Iss 8, p 901 (2020)
Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecule compounds that mimic natural antagonists of inhibitor of apoptosis (IAP) proteins, known as Smac-mimetics (second mito
Externí odkaz:
https://doaj.org/article/7539cde5a1dd4d14aa1973938e0299db
Publikováno v:
Cells, Vol 9, Iss 2, p 406 (2020)
It is well accepted that the ability of cancer cells to circumvent the cell death program that untransformed cells are subject to helps promote tumor growth. Strategies designed to reinstate the cell death program in cancer cells have therefore been
Externí odkaz:
https://doaj.org/article/409ecd0ba5354ab998fdd451c56dff83
Autor:
Cody C. Allison, Benjamin T. Kile, Esme C. Hatchell, Maria Kozlovskaia, Catriona McLean, Pradnya Gangatirkar, Gabriela Brumatti, Marc Pellegrini, Pamela A. McCombe, Julie Sheridan, Donald Metcalf, Klaus Warnatz, Natasha Silke, Maria C. Tanzer, Janelle E. Collinge, Seth L. Masters, Victoria E. Jackson, Jason Corbin, David B. Ascher, Dina Stockwell, Nicole Vlahovich, Zhixiu Li, James M. Murphy, Carola G. Vinuesa, Maria Kauppi, Ronald M. Laxer, John Reveille, Adrienne A. Hilton, John Silke, Ian J. Majewski, David Hughes, Gillian M. Tannahill, Melanie Bahlo, Christine Biben, Michael A. Silk, Maria A. Fiatarone Singh, Cathrine Hall, Peter E. Czabotar, Jian-Guo Zhang, Polly J. Ferguson, Sukhdeep K Spall, Carolyn A. de Graaf, Michael D. Stutz, Nils Venhoff, Alexander G. Bassuk, Zikou Liu, Holly Anderton, Michael S. Hildebrand, Tracy A. Willson, James A Rickard, Hiroyasu Nakano, Vicki Athanasopoulos, Matthew A. Brown, Samuel N. Young, Jens Thiel, Emma J. Petrie, Diep Chau, Sarah E Garnish, Sanae Miyake, Anne Tripaydonis, Warren S. Alexander, Allison Cox, Stefan Blum, Joanne M Hildebrand, Thomas S. Scerri, Kristin A Rigbye, Leila N. Varghese, Benjamin W. Darbro, Emma C. Josefsson, Ladina Di Rago
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, MlklD139V, that alters the two-helix ‘brace’ that connects the killer four-helix bundle and reg
Autor:
Seong Lin Khaw, Nadia May Davidson, Ricky W. Johnstone, Gabriela Brumatti, Paul G Ekert, Stefan Bjelosevic, Hansen J. Kosasih, Margs S. Brennan, Emma Morrish, Alicia Oshlack
Publikováno v:
Blood Adv
Key Points A novel KMT2A-rearrangement, MLL-TFE3, was identified in an infant leukemia patient. MLL-TFE3 expression produces aggressive leukemia in a mouse model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbd94b2818e2154b7cb001e34b331e1
https://europepmc.org/articles/PMC7556123/
https://europepmc.org/articles/PMC7556123/
Autor:
Marc Pellegrini, Gabriela Brumatti, Gregor Ebert, Liana Mackiewicz, John Silke, Emma Morrish, Natasha Silke
Publikováno v:
Viruses
Volume 12
Issue 8
Viruses, Vol 12, Iss 901, p 901 (2020)
Volume 12
Issue 8
Viruses, Vol 12, Iss 901, p 901 (2020)
Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecule compounds that mimic natural antagonists of inhibitor of apoptosis (IAP) proteins, known as Smac-mimetics (second mito
Publikováno v:
Cells, Vol 9, Iss 2, p 406 (2020)
Cells
Cells
It is well accepted that the ability of cancer cells to circumvent the cell death program that untransformed cells are subject to helps promote tumor growth. Strategies designed to reinstate the cell death program in cancer cells have therefore been