Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Gabriel Waksman"'
The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili
Autor:
Dawid S. Zyla, Thomas Wiegand, Paul Bachmann, Rafal Zdanowicz, Christoph Giese, Beat H. Meier, Gabriel Waksman, Manuela K. Hospenthal, Rudi Glockshuber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Type 1 pili are important virulence factors of uropathogenic Escherichia coli that mediate bacterial attachment to epithelial cells in the urinary tract. The pilus rod is comprised of thousands of copies of the main structural subunit FimA a
Externí odkaz:
https://doaj.org/article/884d08eb71b24e7aa30ce532b269e3b7
Autor:
Amit Meir, Kevin Macé, Natalya Lukoyanova, David Chetrit, Manuela K. Hospenthal, Adam Redzej, Craig Roy, Gabriel Waksman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structura
Externí odkaz:
https://doaj.org/article/1f01a2ef3e6d4f6f8a81da89f176c9c9
Autor:
Allison H. Williams, Adam Redzej, Nathalie Rolhion, Tiago R. D. Costa, Aline Rifflet, Gabriel Waksman, Pascale Cossart
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The bacterial stressosome is a large nanomachine and a key inducer of stress response. Here, the authors present the cryo-EM structure of the stressosome from the bacterial pathogen Listeria monocytogenes at 3.38 Å resolution and discuss its activat
Externí odkaz:
https://doaj.org/article/1a99182087754942bc951b83e22f5f47
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Legionella pneumophila employs the Type 4B secretion system (T4BSS) to translocate more than 300 effector proteins into the host cell during infection. Here the authors present the crystal structure of the DotM soluble domain and give mechanistic ins
Externí odkaz:
https://doaj.org/article/6c642b7b193d45158274212a71865767
Publikováno v:
AIMS Biophysics, Vol 2, Iss 2, Pp 184-199 (2015)
Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNA and/or proteins through the membranes of bacteria. Analysis of T4S system architecture is an extremely challenging task taking into account their multi protein organisa
Externí odkaz:
https://doaj.org/article/2fa8f304dbe94ded898658b6af079910
Autor:
Gabriel Waksman, James Lillington
Publikováno v:
Biology, Vol 2, Iss 3, Pp 841-860 (2013)
Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit
Externí odkaz:
https://doaj.org/article/ad60ad65601647659900bb951177460e
Autor:
Irene Farabella, Thieng Pham, Nadine S Henderson, Sebastian Geibel, Gilles Phan, David G Thanassi, Anne H Delcour, Gabriel Waksman, Maya Topf
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/930df1e2c99440c68394abd21d1b9f94
Autor:
Irene Farabella, Thieng Pham, Nadine S Henderson, Sebastian Geibel, Gilles Phan, David G Thanassi, Anne H Delcour, Gabriel Waksman, Maya Topf
Publikováno v:
eLife, Vol 3 (2014)
PapC ushers are outer-membrane proteins enabling assembly and secretion of P pili in uropathogenic E. coli. Their translocation domain is a large β-barrel occluded by a plug domain, which is displaced to allow the translocation of pilus subunits acr
Externí odkaz:
https://doaj.org/article/d13ab33701a7448fa6e5c303747f59c9
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16583 (2011)
Pseudomonas aeruginosa, an important human pathogen, is estimated to be responsible for ∼10% of nosocomial infections worldwide. The pathogenesis of P. aeruginosa starts from its colonization in the damaged tissue or medical devices (e.g. catheters
Externí odkaz:
https://doaj.org/article/27f48d32c601467298e1fa48c829d00a
Publikováno v:
PLoS Pathogens, Vol 3, Iss 5, p e73 (2007)
P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC usher. During pilus assembly, s
Externí odkaz:
https://doaj.org/article/36b768e21e224503b6a5136546fe1f32