Výsledky vyhledávání - "Gabriel W. Intano"

Health Span and Life Span in Transgenic Mice with Modulated DNA Repair

Autor: Gabriel W. Intano, Robert L. Reddick, Damon C. Herbert, Zi Qiang Zhou, Yuji Ikeno, Martha A. Hanes, James F. Nelson, Christi A. Walter, Diwi Manguino, C. Alex McMahan

Publikováno v: Annals of the New York Academy of Sciences. 928:132-140

One way to better understand the contribution of DNA repair, DNA damage, and mutagenesis in aging would be to enhance DNA repair activity, lower DNA damage, and lower mutagenesis. Because the repair protein O6-methylguanine-DNA methyltransferase (MGM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4fecb0ef8a7d6b2b5c4a5797054964
https://doi.org/10.1111/j.1749-6632.2001.tb05643.x

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Rat Synapsin 1 Promoter Mediated Transgene Expression in Testicular Cell Types

Autor: Christi A. Walter, Gabriel W. Intano, Guogang Xu, John R. McCarrey, Damon C. Herbert, Karah A. Street, K L Hall, Manfred W. Kilimann

Publikováno v: DNA and Cell Biology. 24:133-140

Previous reports described the rat synapsin 1 promoter as primarily neuron selective. However, ectopic expression of a transgene under the rat synapsin 1 promoter was also detected in testis from some transgenic mouse lines. Here we investigate which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b361b2d4543bb30349ac4d473113032
https://doi.org/10.1089/dna.2005.24.133

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Autor: Eun Ju Cho, Gabriel W. Intano, Christi A. Walter, C. Alex McMahan

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 58:B205-B211

To assess DNA repair activity relative to age, in vitro base excision repair assays were performed using brain and liver nuclear extracts prepared from mice of various ages. An 85% decline in repair activity was observed in brain nuclear extracts and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6680c6739bc0d600b0f74ae380eec5c
https://doi.org/10.1093/gerona/58.3.b205

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Base Excision Repair Is Limited by Different Proteins in Male Germ Cell Nuclear Extracts Prepared from Young and Old Mice

Autor: Allison E. McKenna, David J. Chen, Yoshihiro Matsumoto, Mark A. MacInnes, C. Alex McMahan, Ronald B. Walter, Christi A. Walter, John R. McCarrey, Gabriel W. Intano

Publikováno v: Molecular and Cellular Biology. 22:2410-2418

The combined observations of elevated DNA repair gene expression, high uracil-DNA glycosylase-initiated base excision repair, and a low spontaneous mutant frequency for a lacI transgene in spermatogenic cells from young mice suggest that base excisio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5e793c522c528e3560b1009509d5da
https://doi.org/10.1128/mcb.22.7.2410-2418.2002

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Relative Base Excision Repair in Xiphophorus Fish Tissue Extracts

Autor: David L. Mitchell, Christi A. Walter, Huang Mo Sung, Gabriel W. Intano, Rebecca D. Obermoeller, Ronald B. Walter

Publikováno v: Marine Biotechnology. 3:S050-S060

To begin characterizing DNA repair capability among Xiphophorus species, we adapted oligonucleotide-based DNA repair assays to extracts of fish tissues. Here, we report the initial results of relative base excision repair (BER) capability among 3 inb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bc17c1fe006f968249b3176800206c
https://doi.org/10.1007/s10126-001-0027-0

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Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O 6 - methylguanine-DNA methyltransferase

Autor: Zi Qiang Zhou, Robert L. Reddick, Martha Hanes, C. Alex McMahan, Diwi Manguino, Gabriel W. Intano, Damon C. Herbert, Yuji Ikeno, Christi A. Walter, Kristen Kewitt

Publikováno v: Proceedings of the National Academy of Sciences. 98:12566-12571

O 6 -methylguanine ( O 6 mG) is a potent mutagenic and procarcinogenic DNA lesion. Organisms have evolved with a DNA repair mechanism that largely ameliorates the deleterious effects of O 6 mG through a direct reversal mechanism by a protein termed O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f875fd22a13f497b62d3f97e59fb1b1a
https://doi.org/10.1073/pnas.221232998

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Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity

Autor: Ronald B. Walter, John R. McCarrey, C. Alex McMahan, Christi A. Walter, Gabriel W. Intano

Publikováno v: Nucleic Acids Research. 29:1366-1372

Spermatogenic cells exhibit a lower spontaneous mutation frequency than somatic tissues in a lacI transgene and many base excision repair (BER) genes display the highest observed level of expression in the testis. In this study, uracil-DNA glycosylas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ce8d3ea2ea02d91ef8c32b6a1194da
https://doi.org/10.1093/nar/29.6.1366

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Recovery of a Low Mutant Frequency after Ionizing Radiation-Induced Mutagenesis during Spermatogenesis

Autor: John R. McCarrey, C. Alex McMahan, Guogang Xu, Ronald B. Walter, Christi A. Walter, Gabriel W. Intano

Humans are exposed to ionizing radiation (IR) under various circumstances, e.g. cosmic radiation, diagnostic X-rays and radiotherapy for cancer. It has been shown that IR can impair spermatogenesis and can cause mutations in germ cells. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4090a0db91995a9324a1a428ade7144e
https://europepmc.org/articles/PMC2543111/

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Mutation spectral changes in spermatogenic cells obtained from old mice

Autor: Christi A. Walter, Ronald B. Walter, Gabriel W. Intano, John R. McCarrey, Kevin Kelner, C. Alex McMahan

Publikováno v: DNA repair. 3(5)

Male reproductive health is compromised with increased paternal age, due at least in part, to an increased frequency of de novo germline mutations. Because of technical and sample limitations, there is a dearth of empirical information on the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68653174ac9b6886fcadaf5db6c416be
https://pubmed.ncbi.nlm.nih.gov/15084311

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Mutation frequency declines during spermatogenesis in young mice but increases in old mice

Autor: C. Alex McMahan, Ronald B. Walter, Christi A. Walter, John R. McCarrey, Gabriel W. Intano

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 95(17)

Five percent of live-born human offspring will have a genetic disorder. Of these, 20% are because of germ-line de novo mutations. Several genetic diseases, such as neurofibromatosis and Duchenne muscular dystrophy, are associated with a high percenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e44530acd85c469ac24cfa6f5a1d48d
https://pubmed.ncbi.nlm.nih.gov/9707592

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