Specific and direct modulation of the interaction between adhesion GPCR GPR56/ADGRG1 and tissue transglutaminase 2 using synthetic ligands

Autor: Demet Araç, Shohei Koide, Shu Zhang, Gabriel S. Salzman, Celia G. Fernandez

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

Blocking the interaction between cell-surface receptors and their ligands is a proven therapeutic strategy. Adhesion G protein-coupled receptors (aGPCRs) are key cell-surface receptors that regulate numerous pathophysiological processes, and their la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aacd8d39785af1390af392c9ab0ef7
https://pubmed.ncbi.nlm.nih.gov/33037308

Stachel -independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region

Autor: Akiko Koide, Shu Zhang, Demet Araç, Shohei Koide, Ankit Gupta, Gabriel S. Salzman

Publikováno v: Proceedings of the National Academy of Sciences. 114:10095-10100

Adhesion G protein-coupled receptors (aGPCRs) play critical roles in diverse biological processes, including neurodevelopment and cancer progression. aGPCRs are characterized by large and diverse extracellular regions (ECRs) that are autoproteolytica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84cc4949d5b9e164ec354cff77887b4
https://doi.org/10.1073/pnas.1708810114

A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

Autor: Sean McSweeney, Sine Larsen, Demet Araç, Matthew W. Bowler, Harm Otten, André Hoelz, Gordon A. Leonard, Navraj S. Pannu, Pavol Skubák, Christoph Mueller-Dieckmann, Ana R. Correia, Gabriel S. Salzman, Andrew A. McCarthy

Publikováno v: International Union of Crystallography journal
International Union of Crystallography journal, International Union of Crystallography 2018, 5 (2), pp.166-171. ⟨10.1107/S2052252517017961⟩
Skubak, P, Arac, D, Bowler, M W, Correia, A R, Hoelz, A, Larsen, S, Leonard, G A, McCarthy, A A, McSweeney, S, Mueller-Dieckmann, C, Otten, H, Salzman, G & Pannu, N S 2018, ' A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model ', I U Cr J, vol. 5, no. Part 2, pp. 166-171 . https://doi.org/10.1107/S2052252517017961
IUCrJ
IUCrJ, Vol 5, Iss 2, Pp 166-171 (2018)
'IUCrJ ', vol: 5, pages: 166-171 (2018)

A new algorithm automatically determines the structures of large macromolecules of unknown fold from low-resolution single-wavelength anomalous X-ray data and a partial model that failed with other methods.
Determining macromolecular structures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a608cc562c8903db559efbfdb27d433
https://hal.archives-ouvertes.fr/hal-02976203/file/IUCrJ_5_166.pdf

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

Autor: Yue C. Lu, Richard Sando, Nan-Sheng Li, Gabriel S. Salzman, Thomas C. Südhof, Demet Araç, Olha V. Nazarko

Publikováno v: Structure. 24(2)

SummaryFibronectin leucine-rich repeat transmembrane proteins (FLRTs) are cell-adhesion molecules with emerging functions in cortical development and synapse formation. Their extracellular regions interact with latrophilins (LPHNs) to mediate synapse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91adf42fc79a6db384d83059004dafde