Výsledky vyhledávání - "Gabriel Rosser"

Akademický článek

Lineage specification in glioblastoma is regulated by METTL7B

Autor: Myrianni Constantinou, James Nicholson, Xinyu Zhang, Eleni Maniati, Sara Lucchini, Gabriel Rosser, Claire Vinel, Jun Wang, Yau Mun Lim, Sebastian Brandner, Sven Nelander, Sara Badodi, Silvia Marino

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114309- (2024)

Summary: Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineag

Externí odkaz: https://doaj.org/article/06de4fe6f43a439db3c5cbbb8e57eff6

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Akademický článek

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the disco

Externí odkaz: https://doaj.org/article/eef727b592d24a7697303fa96e18e608

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Akademický článek

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

Autor: James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino

Publikováno v: eLife, Vol 11 (2022)

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic g

Externí odkaz: https://doaj.org/article/da3de84103274f4e822d1df1abc6378c

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Akademický článek

Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

Autor: Sara Badodi, Nicola Pomella, Xinyu Zhang, Gabriel Rosser, John Whittingham, Maria Victoria Niklison-Chirou, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Christopher D. Bennett, Steven C. Clifford, Andrew Peet, M. Albert Basson, Silvia Marino

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alo

Externí odkaz: https://doaj.org/article/e099abd2067e489ba7b766a7107a8238

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Akademický článek

c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

Autor: Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens, Silvia Marino

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)

Abstract Choroid plexus tumours (CPTs) account for 2–5% of brain tumours in children. They can spread along the neuraxis and can recur after treatment. Little is known about the molecular mechanisms underlying their formation and only few high fide

Externí odkaz: https://doaj.org/article/124de95b234e4a8aad17a71b1c6fbb08

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Akademický článek

Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma

Autor: Sara Badodi, Adrian Dubuc, Xinyu Zhang, Gabriel Rosser, Mariane Da Cunha Jaeger, Michelle M. Kameda-Smith, Anca Sorana Morrissy, Paul Guilhamon, Philipp Suetterlin, Xiao-Nan Li, Loredana Guglielmi, Ashirwad Merve, Hamza Farooq, Mathieu Lupien, Sheila K. Singh, M. Albert Basson, Michael D. Taylor, Silvia Marino

Publikováno v: Cell Reports, Vol 21, Iss 10, Pp 2772-2784 (2017)

Summary: We describe molecular convergence between BMI1 and CHD7 in the initiation of medulloblastoma. Identified in a functional genomic screen in mouse models, a BMI1High;CHD7Low expression signature within medulloblastoma characterizes patients wi

Externí odkaz: https://doaj.org/article/60f4f3d022f54adf9316a3789fd48058

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Akademický článek

Correction to: c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-1 (2019)

In the original version of this article [1], there was 1 error in the affiliation of the European Institute of Oncology (affiliation 3). In this correction article the updated affiliation is shown for clarification.

Externí odkaz: https://doaj.org/article/2cc49146c06e48cda6fef5ed68f93a65

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Akademický článek

Novel methods for analysing bacterial tracks reveal persistence in Rhodobacter sphaeroides.

Autor: Gabriel Rosser, Alexander G Fletcher, David A Wilkinson, Jennifer A de Beyer, Christian A Yates, Judith P Armitage, Philip K Maini, Ruth E Baker

Publikováno v: PLoS Computational Biology, Vol 9, Iss 10, p e1003276 (2013)

Tracking bacteria using video microscopy is a powerful experimental approach to probe their motile behaviour. The trajectories obtained contain much information relating to the complex patterns of bacterial motility. However, methods for the quantita

Externí odkaz: https://doaj.org/article/9661b364f8864725b727c688341b69cb

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