An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity

Autor: Ivana Djuretic, Dave Tsao, Yuanming Xu, Lucia Campos Carrascosa, Gabriel R. Starbeck-Miller, Valeska de Ruiter, Wenjing Yang, Javier Chaparro-Riggers, Zhouhong Ge, Changhua Ji, Tina Mistry, Jaap Kwekkeboom, Lidia Mosyak, John Zeytounian, Matthew Ling-Hon Chu, Renny Feldman, Lisanne Noordam, Eugenia Kraynov, Tzu-Hsuan Huang, Martin E. van Royen, Diamanda Rigas, Sherman M. Chin, Irene Ni, Dave Sprengers, Shih-Hsun Chen, Danielle Pappas, Kevin Lindquist, Michael Doukas, Patrick P.C. Boor, Joanne Verheij, Keith A. Ching, Magdalena Dorywalska, Luz Marina Londono, Joris I. Erdmann, Dirk J. Grünhagen, Laura Lin, Bing Kuang, Jan N. M. IJzermans, Yik Andy Yeung, James Patterson, Jie Guo, Salah Mahmoudi, Terrence Park, Pascal G. Doornebosch, Robert C Rickert

Publikováno v: Cancer Immunology Research, 9(10), 1141-1157. American Association for Cancer Research Inc.
Cancer immunology research, 9(10), 1141-1157. American Association for Cancer Research Inc.

The use of cytokines for immunotherapy shows clinical efficacy but is frequently accompanied by severe adverse events caused by excessive and systemic immune activation. Here, we set out to address these challenges by engineering a fusion protein of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314114dc45d8eb706b8d4a6ebcec02a6
https://doi.org/10.1158/2326-6066.cir-21-0058

VISTA is an activating receptor in human monocytes

Autor: Pingping Zheng, Shiming Ye, Enrico L. Digiammarino, Donghee Choi, Andrew V. Nguyen, Zoltan Dezso, Kathleen McGuire, Bryan M Rogers, Denny Nguyen, Sunantha Sethuraman, Gabriel R. Starbeck-Miller, Debra Chao, Xu Shi, Laura A. Smith, Namjin Chung, Dong Zhang, Wei Liu

Publikováno v: The Journal of Experimental Medicine

VISTA biology has yet to be fully resolved despite much enthusiasm to define it as an immune checkpoint protein. Here, we show that VISTA antibodies can singly activate human monocytes and provide evidence that Syndecan-2 can regulate VISTA interacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d40019dcf8a198d9775ec4d4d9f0000
http://europepmc.org/articles/PMC8193568

Secondary CD8+ T-cell responses are controlled by systemic inflammation

Autor: Matthew D. Martin, Thomas Wirth, Vladimir P. Badovinac, Gabriel R. Starbeck-Miller, John T. Harty

Publikováno v: European Journal of Immunology. 41:1321-1333

Repeated infections and experimental prime-boost regimens frequently result in the generation of secondary (2°) CD8(+) T-cell responses. In contrast to primary (1°) CD8(+) T cells, the parameters that influence the abundance and phenotype of 2° ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb491953a1ca2cea086109139f59400
https://doi.org/10.1002/eji.201040730

The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses

Autor: Gabriel R, Starbeck-Miller, John T, Harty

Publikováno v: Advances in experimental medicine and biology. 850

Antigen-specific CD8 T cells provide an important protective role in response to infection by viruses, intracellular bacteria, and parasites. Pathogen-specific CD8 T cells render this protection by undergoing robust expansion in numbers while gaining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e58a188c7c040012eac18539ecfb3d8
https://pubmed.ncbi.nlm.nih.gov/26324344

IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo

Autor: John T. Harty, Gabriel R. Starbeck-Miller, Hai-Hui Xue

Publikováno v: The Journal of Experimental Medicine

The signal 3 cytokines interleukin-12 and type I interferon sustain CD8 T cell division by prolonging expression of CD25 in vivo.
TCR ligation and co-stimulation induce cellular division; however, optimal accumulation of effector CD8 T cells req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cf5de59092b8a2be75ecce5bb31ed7
https://pubmed.ncbi.nlm.nih.gov/24367005