Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gabriel R. Linares"'
Autor:
Soojin Lee, Yong-Woo Jun, Gabriel R. Linares, Brandon Butler, Yeliz Yuva-Adyemir, Jill Moore, Gopinath Krishnan, Bryan Ruiz-Juarez, Manuel Santana, Marine Pons, Neal Silverman, Zhiping Weng, Justin K. Ichida, Fen-Biao Gao
Publikováno v:
Neuron. 111:1381-1390.e6
Autor:
Gabriel R. Linares, Yichen Li, Wen-Hsuan Chang, Jasper Rubin-Sigler, Stacee Mendonca, Sarah Hong, Yunsun Eoh, Wenxuan Guo, Yi-Hsuan Huang, Jonathan Chang, Sharon Tu, Nomongo Dorjsuren, Manuel Santana, Shu-Ting Hung, Johnny Yu, Joscany Perez, Michael Chickering, Tze-Yuan Cheng, Chi-Chou Huang, Shih-Jong James Lee, Hao-Jen Deng, Kieu-Tram Bach, Kamden Gray, Vishvak Subramanyam, Jeffrey Rosenfeld, Samuel V. Alworth, Hani Goodarzi, Justin K. Ichida
Publikováno v:
Cell Stem Cell. 30:171-187.e14
Autor:
Shu-Ting Hung, Gabriel R. Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samuel V. Alworth, Eric Hendricks, Yaoming Wang, Berislav V. Zlokovic, Dion K. Dickman, J. Alex Parker, Daniela C. Zarnescu, Fen-Biao Gao, Justin K. Ichida
Publikováno v:
Cell. 186:786-802.e28
Autor:
Gabriel R. Linares, Fen-Biao Gao, Zohar Shipony, Manuel Santana, Jacob A. Blum, Rodrigo Lopez-Gonzalez, Marc Tessier-Lavigne, Gokul Ramaswami, Aaron D. Gitler, Yong Jie Zhang, Kyuho Han, Lisa Nakayama, Justin K. Ichida, Kai Ruan, William J. Greenleaf, Maya Maor-Nof, Laura D. Attardi, Michael C. Bassik, Thomas E. Lloyd, Patricia A. Castruita, Julien Couthouis, Leonard Petrucelli, Nasa Sinnott-Armstrong, David J. Simon, Aviv Nof, Daniel H. Geschwind, Jennifer S. Yokoyama
Publikováno v:
Cell, vol 184, iss 3
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a platform to interrogate the chromatin accessibility landscape and transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d841d1b3f0b552a1a6004a2267073e37
https://escholarship.org/uc/item/6cm8z9gp
https://escholarship.org/uc/item/6cm8z9gp
Publikováno v:
Cell biology internationalREFERENCES. 44(10)
The clinical application of stem cells offers great promise as a potential avenue for therapeutic use in neurodegenerative diseases. However, cell loss after transplantation remains a major challenge which currently plagues the field. Based on our pr
Autor:
Justin K. Ichida, Jesse D. Lai, Gabriel R. Linares, Shu-Ting Hung, Tohru Sugawara, Shaoyu Lin, Gabriel Rocha, Yingxiao Shi, Kim A. Staats, Carina Seah, Michael Chickering, Yaoming Wang, Berislav V. Zlokovic, Abhay P. Sagare
Publikováno v:
JCI insight. 5
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with diverse etiologies. Therefore, the identification of common disease mechanisms and therapeutics targeting these mechanisms could dramatically improve clinical outcomes. To this
Autor:
Gabriel R. Linares, Rami Ahmad Shahror, Chung Che Wu, Kai Yun Chen, Shih Chang Hsueh, Yung Hsiao Chiang, De-Maw Chuang, Yun Wang
Publikováno v:
J Neurotrauma
Traumatic brain injury (TBI) is a progressive and complex pathological condition that results in multiple adverse consequences, including impaired learning and memory. Transplantation of mesenchymal stem cells (MSCs) has produced limited benefits in
Autor:
Gabriel R. Linares, Yan Leng, Lisa Scheuing, Hsiao-Mei Liao, Chi-Tso Chiu, De-Maw Chuang, Dragan Maric
Publikováno v:
Experimental Neurology. 281:81-92
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by CAG repeat expansions in the huntingtin gene. Although, stem cell-based therapy has emerged as a potential treatment for neurodegenerative diseases, limitations remain, includi
Autor:
Gabriel R. Linares, Justin K. Ichida, Yingxiao Shi, Brandon B Ge, Yichen Li, Jacob Komberg, R. Jeroen Pasterkamp, Davide Trotti, Valerie Hennes, Leonard H. van den Berg, Nicole Koutsodendris, Jason A. Chen, Kaitlin P. Sandor, Vamshidhar R. Vangoor, Louise Menendez, Amy R. Nelson, Michael E. Ward, Tze-Yuan Cheng, Yaoming Wang, Phillip E. Woolwine, Wen-Hsuan Chang, Ketharini Senthilkumar, Kim A. Staats, Mickey Huang, Carina Seah, Alice Zhang, Chris Grunseich, Esther Y. Son, Eric Hendricks, Michael J. Cowan, Paul R. August, Kassandra Kisler, Shih Jong J. Lee, Marcelo P. Coba, Shu Ting Hung, Shaoyu Lin, Brent Wilkinson, N. Wisniewski, Berislav V. Zlokovic, Tohru Sugawara, T. Grant Belgard, Victor Hanson-Smith, Xinmei Wen
Publikováno v:
Nature Medicine, 24(3), 313. Nature Publishing Group
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b18c3fd3677e0457e409e74f97ed0
https://dspace.library.uu.nl/handle/1874/364200
https://dspace.library.uu.nl/handle/1874/364200
Autor:
Fatima. Z. Alshbool, Gabriel R. Linares, David R. Powell, Shin-Tai Chen, Weirong Xing, Robert Brommage, K-H William Lau, Subburaman Mohan, Jon E. Wergedal
Publikováno v:
Journal of Bone and Mineral Research. 27:1553-1565
Claudin 18 (Cldn-18) belongs to a large family of transmembrane proteins that are important components of tight junction strands. Although several claudin members are expressed in bone, the functional role for any claudin member in bone is unknown. H