UbiD domain dynamics underpins aromatic decarboxylation

Autor: Karl A. P. Payne, Gabriel R. Titchiner, David Leys, Sam Hay, Colin Levy, Karl Fisher, Stephen A Marshall

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

The widespread UbiD enzyme family utilises the prFMN cofactor to achieve reversible decarboxylation of acrylic and (hetero)aromatic compounds. The reaction with acrylic compounds based on reversible 1,3-dipolar cycloaddition between substrate and prF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74886bdbb11f0000c25dd2eb8a91557
https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd

Synthetic Enzyme‐Catalyzed CO 2 Fixation Reactions

Autor: Godwin A. Aleku, George W. Roberts, David Leys, Gabriel R. Titchiner

Publikováno v: ChemSusChem
Aleku, G A, Roberts, G W, Titchiner, G R & Leys, D 2021, ' Synthetic enzyme-catalysed CO2 fixation reactions ', Chemsuschem . https://doi.org/10.1002/cssc.202100159

In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof-of-concept (bio)synthetic CO2 fixation routes for chemical production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981cef0d50780bd1bfa3ceda10cc1083
https://doi.org/10.1002/cssc.202100159

Enzymatic

Autor: Godwin A, Aleku, Gabriel R, Titchiner, George W, Roberts, Sasha R, Derrington, James R, Marshall, Florian, Hollfelder, Nicholas J, Turner, David, Leys

Publikováno v: ACS sustainable chemistryengineering. 10(20)

Allylic amines are a versatile class of synthetic precursors of many valuable nitrogen-containing organic compounds, including pharmaceuticals. Enzymatic allylic amination methods provide a sustainable route to these compounds but are often restricte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0d542fbb6c1bb527c6210be5486cb52
https://pubmed.ncbi.nlm.nih.gov/35634269

Enzymatic C-H activation of aromatic compounds through CO

Autor: Godwin A, Aleku, Annica, Saaret, Ruth T, Bradshaw-Allen, Sasha R, Derrington, Gabriel R, Titchiner, Irina, Gostimskaya, Deepankar, Gahloth, David A, Parker, Sam, Hay, David, Leys

Publikováno v: Nature chemical biology. 16(11)

The direct C-H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step in anaerobic microbial degradation of recalcitran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79f836bfc8ca83acdbca69e2a4ae567d
https://pubmed.ncbi.nlm.nih.gov/32719558

Enzymatic C–H activation of aromatic compounds through CO2 fixation

Autor: Irina Gostimskaya, Godwin A. Aleku, Gabriel R. Titchiner, Annica Saaret, Deepankar Gahloth, David Leys, Sasha R. Derrington, David A. Parker, Ruth T. Bradshaw-Allen, Sam Hay

Publikováno v: Aleku, G, Saaret, A, Bradshaw Allen, R, Derrington, S, Titchiner, G, Gostimskaya, I, Gahloth, D, Parker, D A, Hay, S & Leys, D 2020, ' Enzymatic C-H activation of aromatic compounds through CO2 fixation ', Nature chemical biology, vol. 16, no. 11, pp. 1255-1260 . https://doi.org/10.1038/s41589-020-0603-0
Nature Chemical Biology

The direct C–H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step in anaerobic microbial degradation of recalcitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef88e995d84fd23de75248751abe031f