Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Gabriel Piedrafita"'
Autor:
Gabriel Piedrafita, Vasiliki Kostiou, Agnieszka Wabik, Bartomeu Colom, David Fernandez-Antoran, Albert Herms, Kasumi Murai, Benjamin A. Hall, Philip H. Jones
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Understanding how cells maintain tissues is challenging. Here, the authors present a single consistent quantitative approach to analyse cell proliferation and lineage tracing data, which shows a single proliferating cell population that maintains epi
Externí odkaz:
https://doaj.org/article/11e1473f6ed64141ac21fbcd3f57b93b
Autor:
Gabriel Piedrafita, Sreejith J Varma, Cecilia Castro, Christoph B Messner, Lukasz Szyrwiel, Julian L Griffin, Markus Ralser
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001468 (2021)
The structure of the metabolic network is highly conserved, but we know little about its evolutionary origins. Key for explaining the early evolution of metabolism is solving a chicken-egg dilemma, which describes that enzymes are made from the very
Externí odkaz:
https://doaj.org/article/21656b2790fa4e38b64a797d017961a5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The origin-of-life problem has been traditionally conceived as the chemical challenge to find the type of molecule and free-solution reaction dynamics that could have started Darwinian evolution. Different autocatalytic and ‘self-replicati
Externí odkaz:
https://doaj.org/article/ae7f13ef328746e0a61dd268581f46d2
Publikováno v:
Biomolecules, Vol 5, Iss 3, Pp 2101-2122 (2015)
Cellular metabolism assembles in a structurally highly conserved, but functionally dynamic system, known as the metabolic network. This network involves highly active, enzyme-catalyzed metabolic pathways that provide the building blocks for cell grow
Externí odkaz:
https://doaj.org/article/f27c0b57c28445ca9915964a869b87b3
Autor:
Gabriel Piedrafita, Francisco Montero, Federico Morán, María Luz Cárdenas, Athel Cornish-Bowden
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 8, Pp 861-864 (2010)
A living organism must not only organize itself from within; it must also maintain its organization in the face of changes in its environment and degradation of its components. We show here that a simple (M,R)-system consisting of three interlocking
Externí odkaz:
https://doaj.org/article/526ee2225122426db75ace3ec68bf75d
Autor:
Gabriel Piedrafita, Kepa Ruiz-Mirazo, Pierre-Alain Monnard, Athel Cornish-Bowden, Francisco Montero
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39480 (2012)
In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and s
Externí odkaz:
https://doaj.org/article/1807a6ea0523406eae6edf68de8fa0ba
Autor:
Ricardo Palacios, Elodie Gazave, Joaquín Goñi, Gabriel Piedrafita, Olga Fernando, Arcadi Navarro, Pablo Villoslada
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4150 (2009)
Allelic specific gene expression (ASGE) appears to be an important factor in human phenotypic variability and as a consequence, for the development of complex traits and diseases. In order to study ASGE across the human genome, we have performed a st
Externí odkaz:
https://doaj.org/article/47f08961a09c49feba16ca394e994876
Autor:
Emilie Abby, Stefan C. Dentro, Michael W. J. Hall, Joanna C. Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W. Siebel, Moritz Gerstung, Benjamin A. Hall, Philip H. Jones
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this hypothesis. Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3995a6ea6c8197c93dc9b47a0c6967
https://www.repository.cam.ac.uk/handle/1810/346529
https://www.repository.cam.ac.uk/handle/1810/346529
Autor:
Albert Herms, David Fernandez-Antoran, Maria P. Alcolea, Argyro Kalogeropoulou, Ujjwal Banerjee, Gabriel Piedrafita, Emilie Abby, Jose Antonio Valverde-Lopez, Inês S. Ferreira, Stefan C. Dentro, Swee Hoe Ong, Bartomeu Colom, Kasumi Murai, Charlotte King, Krishnaa Mahbubani, Kourosh Saeb-Parsy, Alan R Lowe, Moritz Gerstung, Philip H Jones
Studying long-term biological processes such as the colonization of aging epithelia by somatic mutant clones has been slowed by the lack of suitable culture systems. Here we describe epithelioids, a facile, cost-effective method of culturing multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be52034b8d198820e25cae713558400a
https://doi.org/10.1101/2023.01.03.522589
https://doi.org/10.1101/2023.01.03.522589
Autor:
Swee Hoe Ong, Joanna C. Fowler, Charlotte King, Michael W. J. Hall, Moritz Gerstung, Bartomeu Colom, Philip H. Jones, Gabriel Piedrafita, Sood R, Agnieszka Wabik, Stefan C. Dentro, Maria P. Alcolea, Inigo Martincorena, Benjamin A. Hall, Albert Herms
Publikováno v:
Nature Genetics. 52:604-614
During aging, progenitor cells acquire mutations, which may generate clones that colonize the surrounding tissue. By middle age, normal human tissues, including the esophageal epithelium (EE), become a patchwork of mutant clones. Despite their releva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54852df30674d4ce50474c15d4017ca5
https://doi.org/10.1038/s41588-020-0624-3
https://doi.org/10.1038/s41588-020-0624-3