Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gabriel Nuñez-Vivanco"'
Autor:
José A. Pino, Gabriel Nuñez-Vivanco, Gabriela Hidalgo, Miguel Reyes Parada, Habibeh Khoshbouei, Gonzalo E. Torres
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The dopamine transporter (DAT) plays a crucial role in the regulation of brain dopamine (DA) homeostasis through the re-uptake of DA back into the presynaptic terminal. In addition to re-uptake, DAT is also able to release DA through a process referr
Externí odkaz:
https://doaj.org/article/a9c98e7752c54cb9b32191454617d4fc
Autor:
Alejandro Valdés-Jiménez, Carlos Peña-Varas, Paola Borrego-Muñoz, Lily Arrue, Melissa Alegría-Arcos, Hussam Nour-Eldin, Ingo Dreyer, Gabriel Nuñez-Vivanco, David Ramírez
Publikováno v:
Molecules, Vol 26, Iss 4, p 1124 (2021)
Plants synthesize a large number of natural products, many of which are bioactive and have practical values as well as commercial potential. To explore this vast structural diversity, we present PSC-db, a unique plant metabolite database aimed to cat
Externí odkaz:
https://doaj.org/article/9c8c2e3aadb24e2fa6c5fe1a23fae48f
Autor:
Patricia Möller-Acuña, J Sebastián Contreras-Riquelme, Cecilia Rojas-Fuentes, Gabriel Nuñez-Vivanco, Jans Alzate-Morales, Patricio Iturriaga-Vásquez, Hugo R Arias, Miguel Reyes-Parada
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134444 (2015)
Evidence from systems biology indicates that promiscuous drugs, i.e. those that act simultaneously at various protein targets, are clinically better in terms of efficacy, than those that act in a more selective fashion. This has generated a new trend
Externí odkaz:
https://doaj.org/article/b6ff2c52ab2c48fc83667a7baf5fbae6
Autor:
Alejandro Valdés-Jiménez, Daniel Jiménez-González, Aytug K. Kiper, Susanne Rinné, Niels Decher, Wendy González, Miguel Reyes-Parada, Gabriel Núñez-Vivanco
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable first step for the design of no
Externí odkaz:
https://doaj.org/article/197170dac86541658f2b64ec95dd9c6f
Autor:
Gabriel Núñez-Vivanco, Angélica Fierro, Pablo Moya, Patricio Iturriaga-Vásquez, Miguel Reyes-Parada
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200637 (2018)
The study of binding site similarities can be relevant to understand the interaction of different drugs at several molecular targets. The increasing availability of protein crystal structures and the development of novel algorithms designed to evalua
Externí odkaz:
https://doaj.org/article/7b5a8916c3d64e4f868707fda299f4de
Autor:
Juan Pablo González-Gutiérrez, Hernán Armando Pessoa-Mahana, Patricio Ernesto Iturriaga-Vásquez, Miguel Iván Reyes-Parada, Nicolas Esteban Guerra-Díaz, Martin Hodar-Salazar, Franco Viscarra, Pablo Paillali, Gabriel Núñez-Vivanco, Marcos Antonio Lorca-Carvajal, Jaime Mella-Raipán, María Carolina Zúñiga
Publikováno v:
Molecules, Vol 24, Iss 20, p 3808 (2019)
Nicotinic acetylcholine receptors (nAChRs), serotonin transporters (SERT) and dopamine transporters (DAT) represent targets for the development of novel nicotinic derivatives acting as multiligands associated with different health conditions, such as
Externí odkaz:
https://doaj.org/article/54b84d602fb54176b3b2e06d275c291c
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3174 (2019)
Discovering conserved three-dimensional (3D) patterns among protein structures may provide valuable insights into protein classification, functional annotations or the rational design of multi-target drugs. Thus, several computational tools have been
Externí odkaz:
https://doaj.org/article/e31ba9fb812e40ad8ddb7d947fab0ee5