Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gabriel Morrhaye"'
Autor:
Gabriel Morrhaye, Hamid Kermani, Jean-Jacques Legros, Frederic Baron, Yves Beguin, Michel Moutschen, Remi Cheynier, Henri J Martens, Vincent Geenen
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5668 (2009)
Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty in adults. In rodents, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and GH secretagogues reverse age-related changes in
Externí odkaz:
https://doaj.org/article/f5c4f8eb2e2146f38fd3a9e71879243f
Autor:
Vincent Geenen, Florence Debacq-Chainiaux, Henri Martens, Khalil Farhat, Marie de Saint-Hubert, Gabriel Morrhaye, Christian Swine, Gwennaëlle Bodart, Lindsay Goffinet
Publikováno v:
Annals of the New York Academy of Sciences. 1351:61-67
Immunosenescence, characterized by complex modifications of immunity with age, could be related to frailty syndrome in elderly individuals, leading to an inadequate response to minimal aggression. Functional decline (i.e., the loss of ability to perf
Autor:
Gabriel Morrhaye, Hamid Kermani, Marie Mottet, Gwennaëlle Bodart, Vincent Geenen, Chantal Renard, Alisson Beckers, Lindsay Goffinet, Henri Martens
Publikováno v:
Neuroimmunomodulation. 18:314-319
Before being able to react against infectious non-self-antigens, the immune system has to be educated in recognition and tolerance of neuroendocrine self-proteins. This sophisticated educational process takes place only in the thymus. The development
Autor:
Vincent Geenen, Olivier Toussaint, Emilie Bauwens, Florence Debacq-Chainiaux, Christian Swine, Marie de Saint-Hubert, Patrice Godard, Thi Kim Duy Vo, Henri Martens, Gabriel Morrhaye, Youri Glupczynski
Publikováno v:
Experimental Gerontology. 45:188-194
Age-related changes of gene expression contribute to the physiological alteration observed with human ageing. Herein, the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC o
Autor:
Gwennaelle, Bodart, Lindsay, Goffinet, Gabriel, Morrhaye, Khalil, Farhat, Marie, de Saint-Hubert, Florence, Debacq-Chainiaux, Christian, Swine, Vincent, Geenen, Henri J, Martens
Publikováno v:
Annals of the New York Academy of Sciences. 1351
Immunosenescence, characterized by complex modifications of immunity with age, could be related to frailty syndrome in elderly individuals, leading to an inadequate response to minimal aggression. Functional decline (i.e., the loss of ability to perf
Autor:
Lut Overbergh, Lindsay Goffinet, Yves Beguin, Frédéric Baron, Henri Martens, Gabriel Morrhaye, Chantal Renard, Gwenaelle Bodart, Olivier Dardenne, Hamid Kermani, Marie Mottet, Vincent Geenen
Publikováno v:
Neuroimmunomodulation. 19(3)
Aims: We address the question of the expression and the role of the growth hormone/insulin-like growth factor (GH/IGF) axis in the thymus. Methods: Using RT-qPCR, the expression profile of various components of the somatotrope GH/IGF axis was measure
Autor:
Henri Martens, Vincent Geenen, Christian Swine, Florence Debacq-Chainiaux, Marie de Saint-Hubert, Olivier Toussaint, Patrice Godard, Gabriel Morrhaye, Thi Kim Duy Vo
Publikováno v:
Mechanisms of Ageing and Development; Vol 132
The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart failure and at recovery. This study identified 22
Autor:
Marie de Saint-Hubert, Henri Martens, Thi Kim Duy Vo, Christian Swine, Vincent Geenen, Gabriel Morrhaye, Patrice Godard, Florence Debacq-Chainiaux, Olivier Toussaint
Publikováno v:
Experimental gerontology. 46(4)
The abundance of a selection of transcript species involved in inflammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2-4 after hospitalization) or convalescence ph
Autor:
Marie, de Saint-Hubert, Jacques, Jamart, Gabriel, Morrhaye, Henri J, Martens, Vincent, Geenen, Thi Kim, Duy Vo, Olivier, Toussaint, Christian, Swine
Publikováno v:
Aging clinical and experimental research. 23(2)
Although inflammatory and hormonal markers have been associated with further functional adverse outcomes in community- dwelling seniors, these markers have not been studied from this perspective in acutely ill older patients. This prospective study w
Autor:
gabriel morrhaye, France Bruck, Marie de Saint-Hubert, Geoffroy Weemaels, Christian Swine, Olivier Toussaint, Vincent Geenen, Henri Martens
Publikováno v:
The Journal of Immunology. 178:S120-S120
A determinant factor of immunosenescence is the involution of the T-cell compartment, due to a decline in thymic generation of a diverse T-cell repertoire, as well as in peripheral T-cell homeostasis. Human immunosenescence was investigated through m