Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gabriel Martinez Botella"'
Autor:
Dean J. Welsch, Saurabh Saha, Caroline M. Emery, Mark Namchuk, Gary DeCrescenzo, Anna Groover, Kathryn Meshaw, Ramin Samadani, Michael J. Wick, Paul Shapiro, Matthew Fitzgibbon, Gabriel Martinez-Botella, David A. Sorrell, Diane M. Boucher, Michael Hale, Jeffrey J. Roix, Alex M. Aronov, Russell R. Hoover, William Markland, Brinley F. Furey, Ursula A. Germann
Supplementary materials and methods and supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2691c8ce88b24315d90208e7f0fa7411
https://doi.org/10.1158/1535-7163.22508691.v1
https://doi.org/10.1158/1535-7163.22508691.v1
Autor:
Dean J. Welsch, Saurabh Saha, Caroline M. Emery, Mark Namchuk, Gary DeCrescenzo, Anna Groover, Kathryn Meshaw, Ramin Samadani, Michael J. Wick, Paul Shapiro, Matthew Fitzgibbon, Gabriel Martinez-Botella, David A. Sorrell, Diane M. Boucher, Michael Hale, Jeffrey J. Roix, Alex M. Aronov, Russell R. Hoover, William Markland, Brinley F. Furey, Ursula A. Germann
In SW48 colorectal cells engineered with KRAS alleles, response to paclitaxel was unaltered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37056904b019df912ca990e86321623e
https://doi.org/10.1158/1535-7163.22508697.v1
https://doi.org/10.1158/1535-7163.22508697.v1
Autor:
Kristopher M, Kahlig, Liam, Scott, Robert J, Hatch, Andrew, Griffin, Gabriel, Martinez Botella, Zoë A, Hughes, Marion, Wittmann
Publikováno v:
Epilepsia. 63:697-708
This study investigates the effects of PRAX-562 on sodium current (IInhibition of IPRAX-562 potently and preferentially inhibited persistent IPRAX-562 demonstrated robust preclinical anticonvulsant activity similar to CBZ but improved compared to LTG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e4caa61456c198a9870ccfc0b2672e
https://doi.org/10.1111/epi.17149
https://doi.org/10.1111/epi.17149
Autor:
Brian Edward Marron, Brett Antonio, Griffin Andrew, Robert John Hatch, Zoë A Hughes, Kristopher M Kahlig, Mark L. Chapman, Gabriel Martinez-Botella, Marion Wittmann
Publikováno v:
ACS Medicinal Chemistry Letters. 12:593-602
The gene KCNT1 encodes the sodium-activated potassium channel KNa1.1 (Slack, Slo2.2). Variants in the KCNT1 gene induce a gain-of-function (GoF) phenotype in ionic currents and cause a spectrum of intractable neurological disorders in infants and chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd464a8091b097d0667f762facfa9d6
https://doi.org/10.1021/acsmedchemlett.0c00675
https://doi.org/10.1021/acsmedchemlett.0c00675
Autor:
James J. Doherty, Michael A. Ackley, Ethan Hoffmann, Tatiana M. Kazdoba, Zhu Bai, Boyd L. Harrison, Albert J. Robichaud, Andrew Griffin, Mike Lewis, Gabriel Martinez Botella, Francesco G. Salituro, Daniel S. La, Jing Dai, Michael Quirk
Publikováno v:
Journal of Medicinal Chemistry. 62:7526-7542
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(S)-hydroxycholesterol (24(S)-HC), is a positive allosteric modulator (PAM) of NMDA receptors. Using 24(S)-HC as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85c93f6e01f9e02e46c0fd48ba0202c
https://doi.org/10.1021/acs.jmedchem.9b00591
https://doi.org/10.1021/acs.jmedchem.9b00591
Autor:
Diane M. Boucher, David Sorrell, Kathryn R. Meshaw, Dean Welsch, Michael J. Wick, William Markland, Alex Aronov, Saurabh Saha, Matthew J. Fitzgibbon, Mark N. Namchuk, Ramin Samadani, Gabriel Martinez-Botella, Michael R. Hale, Ursula A. Germann, Caroline Emery, Brinley Furey, Russell R. Hoover, Decrescenzo Gary A, Paul Shapiro, Anna L. Groover, Jeffrey James Roix
Publikováno v:
Molecular Cancer Therapeutics. 16:2351-2363
Aberrant activation of signaling through the RAS–RAF–MEK–ERK (MAPK) pathway is implicated in numerous cancers, making it an attractive therapeutic target. Although BRAF and MEK-targeted combination therapy has demonstrated significant benefit b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ad2b8a2758767185013dc44e83f636
https://doi.org/10.1158/1535-7163.mct-17-0456
https://doi.org/10.1158/1535-7163.mct-17-0456
Autor:
Francesco G. Salituro, Gabriel Martinez Botella, James J. Doherty, Rebecca S. Hammond, Alison L. Althaus, Carla Maciag, Albert J. Robichaud, Michael A. Ackley
Publikováno v:
Epilepsy Research. 134:16-25
Despite the availability of multiple antiepileptic drugs (AED), failure to adequately control seizures is a challenge for approximately one third of epilepsy patients, and new therapies with a differentiated mechanism of action are needed. The neuroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ebdf33e1a2544115114f31f08ce039
https://doi.org/10.1016/j.eplepsyres.2017.05.001
https://doi.org/10.1016/j.eplepsyres.2017.05.001
Autor:
Daniel S, La, Francesco G, Salituro, Gabriel, Martinez Botella, Andrew M, Griffin, Zhu, Bai, Michael A, Ackley, Jing, Dai, James J, Doherty, Boyd L, Harrison, Ethan C, Hoffmann, Tatiana M, Kazdoba, Michael C, Lewis, Michael C, Quirk, Albert J, Robichaud
Publikováno v:
Journal of medicinal chemistry. 62(16)
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8edd1a5945ab2bc16424985f2d7c6fb6
https://pubmed.ncbi.nlm.nih.gov/31390523
https://pubmed.ncbi.nlm.nih.gov/31390523
Autor:
Zhu Bai, Scott J. Grossman, Jiamiao Wang, Richard Thomas Beresis, Ethan Hoffmann, Gabriel Martinez Botella, Carlos M. Loya, Kaisheng Shen, Francesco G. Salituro, Albert J. Robichaud, Boyd L. Harrison, Michael A. Ackley, Shiling Jia, Gabriel M. Belfort, James J. Doherty
Publikováno v:
Journal of Medicinal Chemistry. 58:3500-3511
Neuroactive steroids (NASs) have been shown to impact central nervous system (CNS) function through positive allosteric modulation of the GABA(A) receptor (GABA(A)-R). Herein we report the effects on the activity and pharmacokinetic properties of a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526fcbe06be37d20a154344dc5f6e61e
https://doi.org/10.1021/acs.jmedchem.5b00032
https://doi.org/10.1021/acs.jmedchem.5b00032
Autor:
Ethan Hoffmann, Carlos M. Loya, Albert J. Robichaud, Boyd L. Harrison, Richard Thomas Beresis, Jing Dai, Gabriel M. Belfort, Alison L. Althaus, Michael A. Ackley, James J. Doherty, Maria-Jesus Blanco, Zhu Bai, Scott J. Grossman, Francesco G. Salituro, Gabriel Martinez Botella
Publikováno v:
Journal of medicinal chemistry. 60(18)
Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series of 5β-nor-19-pregnan-20-one analogues bearing substituted pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92adadab7380c7344ed988b15618ea47
https://pubmed.ncbi.nlm.nih.gov/28753313
https://pubmed.ncbi.nlm.nih.gov/28753313